Clinical trials: Inappropriate Prescribing
Prescribing Patterns, Physician, Physician's Practice Patterns
Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support
The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize…
- Conditions
- Prescribing Patterns, Physician, Physician's Practice Patterns, Drug Utilization Review
- Trial name
- NCT06998966
- Testing
- Algorithmic Defaulting (Indication-Based Default), Active Physician Choice
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of California, Los Angeles
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Pilot Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454960)
- Testing
- Clinical Decision Support: Accountable Justification, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Southern California
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454947)
- Testing
- Clinical Decision Support (CDS): Accountable Justifications, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- 55 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Southern California
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Functional Autonomy Level
Optimization of Drug Prescribing in an Elderly Population of Geriatric Consultations
Aging is often associated with multiple chronic conditions conducting increased consumption of drugs. Drug therapy is necessary for the treatment of many diseases.
- Trial name
- OPTIM (NCT02740764)
- Testing
- Optimization of drug prescribing
- Where
- 2 sites in France
- Volunteers
- 302 people
- Sponsor
- Hospices Civils de Lyon
Healthy
Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria
Potentially inappropriate prescribing is common in older patients and encompasses overuse, misuse and underuse of medications. Potentially inappropriate prescribing is associated with negative outcomes including adverse drug…
- Trial name
- NCT00915824
- Testing
- STOPP/START criteria
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cork University Hospital
Potentially Inappropriate Medications
An Intuitive, Non-intrusive, Approach to Reduce Patient Harm From Inappropriate Dosing of High-risk Drugs in Older Adult Patients Across an Urban Safety Net Hospital System
This study will assess whether a modification in the default dose and frequency (the first option a provider sees) during electronic prescribing of a high-risk drug can impact prescribing behavior and subsequent changes in…
- Trial name
- NCT05218343
- Testing
- EHR-based "nudge" interventions
- Where
- 2 sites in United States
- Volunteers
- 8,640 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Polypharmacy, Multimorbidity
A Multidisciplinary Intervention Including a Clinical Decision Support System and an App for Drug Therapy Management in Older Patients
"La Casa nel Parco" (CANP) Project is a European Union and Regione Piemonte funded multidisciplinary project aimed to explore innovative technology application in older subject care.
- Conditions
- Polypharmacy, Multimorbidity, Aged
- Trial name
- FARMA-CANP (NCT04391218)
- Testing
- Multidisciplinary Approach Group
- Volunteers
- 89 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Medication Therapy Management
A Collaborative Approach to Medication Reviews for Older Patients With Polypharmacy
In patients aged 65 years and older, polypathology is frequent and often associated with polypharmacy. This polypharmacy may be a source of iatrogeny due to pharmacokinetic interactions, enhanced sensitivity of older people to…
- Trial name
- BIMEDOC (NCT03909035)
- Testing
- Medication therapy management
- Where
- France
- Volunteers
- 697 people
- Sponsor
- University Hospital, Toulouse
Deprescriptions, Aged
Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults
The goal of this randomized controlled trial is to assess the effectiveness of a pharmacist-led medication review using the locally developed Malaysian Potentially Inappropriate Prescribing Screening tool in Older Adults…
- Conditions
- Deprescriptions, Aged, Inappropriate Prescribing, Potentially Inappropriate Medications
- Trial name
- NCT05875623
- Testing
- MALPIP criteria
- Where
- Malaysia
- Volunteers
- 500 people
- Sponsor
- Monash University
Prescribing
Testing CDS in OSCAR EMR Using STOPP Criteria
This mixed methods study seeks to assess and understand the impact of using an advanced CDS tool to present the STOPP criteria to support prescribers at the point of decision-making.
- Trial name
- STOPP-RCT (NCT02130895)
- Testing
- STOPP Criteria Decision Support Content
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aging
Reducing Potentially Inappropriate Medication Prescribing for Older Patients in the ED
This research is being conducted to learn which implementation strategy of EQUIPPED is most effective to improve prescribing practices of ED providers toward older Veterans and determine the factors influencing implementation of…
- Trial name
- EQUIPPED (NCT04004936)
- Testing
- EQUIPPED with Active Feedback, EQUIPPED with Passive Feedback
- Where
- 4 sites in United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Inappropriate Prescribing
Tool for Inappropriate Prescription Evaluation: The TaIPE Study
A mono-center, randomized controlled trial will be conducted at the University Hospital of Lausanne. Hospitalized patients will be randomly assigned from the emergency department to two sub-units composing the acute care for…
- Trial name
- TaIPE (NCT04028583)
- Testing
- PIM-Check, STOPP/START
- Where
- Switzerland
- Volunteers
- 464 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois