Clinical trials: Inappropriate Prescribing, active
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Inappropriate Prescribing
A Trial to Reduce Inappropriate Prescribing to Older Adults Visiting the Emergency Department
Cluster-randomized trial assessing the impact of interventions on guideline-concordant prescribing in Emergency Departments (ED).
- Trial name
- NCT07146763
- Testing
- Prescribing Feedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Yale University
Prescribing Patterns, Physician, Physician's Practice Patterns
Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support
The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize…
- Conditions
- Prescribing Patterns, Physician, Physician's Practice Patterns, Drug Utilization Review
- Trial name
- NCT06998966
- Testing
- Algorithmic Defaulting (Indication-Based Default), Active Physician Choice
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of California, Los Angeles
Inappropriate Prescribing
The Study in Outpatient Medicine Using Nudges to Improve Sleep
The goal of this clinical trial is to learn if electronic health record (EHR) nudges (changes to the EHR that do not restrict freedom of choice or alter incentives) can reduce Z-drug prescribing in primary care clinics for…
- Trial name
- SOMNUS (NCT06640023)
- Testing
- Z-drug Default Quantity, Redirection + Accountable Justification
- Where
- United States
- Volunteers
- 444 people
- Sponsor
- University of Southern California
Potentially Inappropriate Medications
PIM Incidence in Older Cardiovascular Patients During COVID-19 Pandemics
The aim of the study is to assess the incidence of potentially inappropriate medication (PIM) administration, polypharmacy, and potential drug-drug-interactions (PDDIs) in cardiovascular patients enrolled in the reimbursement…
- Trial name
- PIM-BARS (NCT05336565)
- Testing
- Electronic medical record analysis
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Inappropriate Prescribing
Ensuring Clinical Appropriateness and Safety of Pharmacological Therapies in Nursing Home Residents
The goal of this clinical study is to evaluate whether a structured, clinical pharmacology team-led medication review improves the appropriateness and safety of medication prescribing in elderly nursing home (NH) residents.
- Trial name
- NCT07407387
- Testing
- Multi-Component Intervention on Medication Prescribing
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- Lugano Istituti Sociali
Drug-Related Side Effects and Adverse Reaction, Digoxin Overdose
Introducing Electronic Alerts to Reduce Inappropriate Digoxin Prescribing in Older Adults
The intervention consists of introducing computerized alerts into the electronic medical record of the CSAPG (MIRA software), which are triggered when a physician prescribes digoxin at a dose higher than the recommended amount…
- Trial name
- Aldigo (NCT07008144)
- Testing
- Digoxin alarm
- Where
- 2 sites in Spain
- Volunteers
- 5,954 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Low-Value Care
EVOLV-Rx VA: Evaluating Opportunities to Decrease Low-Value Prescribing in Community Living Centers
The investigators developed EVOLV-Rx (Evaluating Opportunities to Decrease Low-Value Prescribing), a novel clinical support tool to detect 18 evidence-based and clinically useful low-value prescribing practices in older adults.
- Trial name
- NCT07166107
- Testing
- EVOLV-Rx dashboard
- Where
- 3 sites in United States
- Volunteers
- 1,161 people
- Sponsor
- VA Office of Research and Development