Clinical trials: Inappropriate Use
Antibiotics Causing Adverse Effects in Therapeutic Use
De-Implementation of Inappropriate Antimicrobial Use After Cardiac Device Procedures
This project will use automated audit and feedback to improve compliance with antimicrobial prophylaxis guidelines for CIED procedures that we anticipate will translate into better outcomes for our patients.
- Trial name
- CIED (NCT05020418)
- Testing
- Chart Review
- Where
- United States
- Volunteers
- 5,469 people
- Sponsor
- VA Office of Research and Development
Primary Health Care
Impact of a Community-Based Primary Health Care Project on the Inappropriate Use of Emergency Medical System in Bergamo
The goal of this study is to reduce the inappropriate use of the Emergency Medical System in Bergamo. The main question it aims to answer is: can a Community-Based Primary Health Care Project impact on the use of the Emergency…
- Trial name
- PHC-BG_EMS (NCT06862882)
- Testing
- Community-Based Primary Health Care
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione San Giuliano Onlus
Gastrointestinal Disease
Proton Pump Inhibitor (PPI) Inappropriate Use and Economic Burden in Chinese Population
This is a descriptive retrospective database analysis study in using database. All patients with a physician PPI prescription will be selected to estimate the PPI inappropriate use.
- Trial name
- ECHO (NCT03118778)
- Where
- China
- Volunteers
- 90,895 people
- Sponsor
- AstraZeneca
Antidiuretic Hormone, Inappropriate Secretion
Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in SIADH
The purpose of this study is to confirm the safety of tolvaptan in patients with hyponatremia in syndrome of inappropriate antidiuretic hormone secretion (SIADH) in Japan
- Trial name
- NCT04790175
- Testing
- Tolvaptan (SAMSCA)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Inappropriate Drug Prescription and Use
Educational and Informative Interventions to Tackle Inappropriate Use of Drugs in Italy
Pharmacological intervention is an essential step in health promotion. However, lots of drugs are often used in inappropriate ways, especially in elderly patients.
- Trial name
- EDUREDRUG (NCT04030468)
- Testing
- Educational intervention addressed to general practitioners, Informative intervention addressed to patients
- Where
- Italy
- Volunteers
- 4,840 people, healthy volunteers welcome
- Sponsor
- University of Milan
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Biological Markers, Inappropriate Prescribing
Big Data Analysis of the Use of bIomarkers Concentration
The investigators conducted a retrospective analysis of all measured concentrations performed in a large subset of laboratories located in the French Brittany from February 2010 the 17th to August 2015 the 30th, in adults over 20…
- Trial name
- rUBIDIuM (NCT03254472)
- Testing
- Measured concentrations of biomarkers
- Where
- France
- Volunteers
- 585,745 people
- Sponsor
- Hospital Avicenne
Polypharmacy, Incontinence
An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults
An educational intervention targeting community-dwelling older adults will lead to a reduction in potentially inappropriate prescriptions (e.g. benzodiazepines, oxybutynin).
- Conditions
- Polypharmacy, Incontinence, Insomnia, Anxiety
- Trial name
- NCT01148186
- Testing
- knowledge transfer tool
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Ventricular Tachycardia, Ventricular Fibrillation
The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock
The RAPTURE Study will determine whether dual chamber defibrillators with atrial prevention and termination therapies, minimized ventricular pacing, and remote monitoring will reduce the rate of inappropriate shocks and improve…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Atrial Fibrillation, Supraventricular Tachycardia
- Trial name
- RAPTURE (NCT00787800)
- Testing
- Dual Chamber ICD, Single Chamber ICD
- Where
- 4 sites in United States, Israel
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Antimicrobial Stewardship, Acute Bronchitis
Using Behavioral Science to Reduce Inappropriate Antibiotic Use in Acute Care Settings
Stepped wedge behavioral intervention clinical trial looking at the impact of an antibiotic stewardship intervention on provider prescribing behavior for acute respiratory infections (ARIs), where the intervention is administered…
- Conditions
- Antimicrobial Stewardship, Acute Bronchitis, Upper Respiratory Infection
- Trial name
- NCT03711292
- Testing
- Antibiotic Stewardship
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Plain Abdominal Radiography
Using a Computer-assisted Prescription to Decrease Inappropriate Use of Plain Abdominal Radiography in Emergency Department
The aim of this study is to assess whether a computer-assisted prescription allows a reduction of the overall number of inappropriate PAR in emergency departments.
- Trial name
- NCT04116294
- Testing
- Computer-assisted prescription
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- Christophe Fehlmann
Dementia
Reducing Inappropriate Medication Use for BPSD
Investigators previously developed a low-cost, practical, patient- and care partner-centric, evidence-informed systematic approach (the "DICE Approach" or DICE), to assess and manage behavioral and psychological symptoms of…
- Trial name
- NCT06040502
- Testing
- The DICE Approach
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of California, Davis
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Patient Factors Associated With Prescription of Antibiotics for Inappropriate Indication in Patients With AECOPD
Up to 90% of consulting Acute Exacerbation (AE) of COPD patients are prescribed an antibiotic(1). Rates of inappropriate antibiotic prescription percentage can be as high as 65%(2).
- Trial name
- NCT03077152
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Behavioral Intervention, Emergency Department Visits
CMSL Ambulatory Sensitive Condition Nudge Study 2
The project aims to evaluate a nurse-led intervention to reduce inappropriate emergency department (ED) use among adult patients seen at Geisinger's Community Medicine Service Line (CMSL) clinics.
- Conditions
- Behavioral Intervention, Emergency Department Visits, Nurse Care Coordination
- Trial name
- NCT07028398
- Testing
- Nurse Nudge
- Where
- United States
- Volunteers
- 12,990 people
- Sponsor
- Geisinger Clinic
Overactive Bladder Syndrome
Effectiveness of a Structured Intervention to Optimize the Use of Mirabegron
This study was a multicentre, quasi-experimental design, controlled, before-and-after trial to estimate the effectiveness related to the review of mirabegron use and, if appropriate, its discontinuation.
- Trial name
- NCT03536494
- Testing
- Review the use of mirabegron and its discontinuation
- Volunteers
- 1,932 people
- Sponsor
- Catalan Institute of Health
Acute Respiratory Tract Infection
Evaluation of an Algorithm to Reduce Antibiotic Prescribing for Acute Bronchitis
Inappropriate use of antibiotics to treat patients with acute bronchitis is a significant factor contributing to the selection of antimicrobial drug resistant pathogens, which threaten the effectiveness of available therapies to…
- Trial name
- NCT00981994
- Testing
- Decision Support for ARI Management
- Volunteers
- 3,300 people
- Sponsor
- University of Pennsylvania
Adverse Drug Effects
The Use of STOPP/START Criteria for Medication Intervention Among Elderly Population Living in a Geriatric Hospital
The purpose of this study is to determine if the use of STOPP/START criteria (STOPP-screening tool of older persons potentially inappropriate prescriptions START-screening tool to alert doctors to right treatment)for medication…
- Trial name
- STOPP (NCT01602744)
- Testing
- STOPP/START screening tools for medication intervention
- Where
- Israel
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Psychotropic Drugs, Psychiatric Drugs
Decreasing Harms and Improving Child Health
The investigators are doing this study because they know from research and talking with caregivers that kids can be on a bunch of medications, and it's hard to keep track of what the medications are for and whether or not they…
- Conditions
- Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making
- Trial name
- NCT07392489
- Testing
- AWARE Shared Decision Making Medication Review
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Glyn Jones-Elwyn
Proton Pump Inhibitor Adverse Reaction, Liver Cirrhosis
Proton Pump Inhibitors in Cirrhotic Patients
Proton pump inhibitors (PPIs) inappropriate use, in patients with cirrhosis, presents a significant clinical challenge. This study evaluates overprescription and misuse of PPIs in cirrhotic patients.
- Trial name
- NCT06384443
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- National Liver Institute, Egypt
Prescribing Patterns, Physician, Physician's Practice Patterns
Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support
The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize…
- Conditions
- Prescribing Patterns, Physician, Physician's Practice Patterns, Drug Utilization Review
- Trial name
- NCT06998966
- Testing
- Algorithmic Defaulting (Indication-Based Default), Active Physician Choice
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of California, Los Angeles