Clinical trials: Incision Infection
Acute Appendicitis
Single Incision Versus Conventional Laparoscopic Appendectomy
This is a randomized prospective study comparing single incision versus conventional laparoscopic appendectomy for management of acute appendicitis.
- Trial name
- NCT01424631
- Testing
- single incision laparoscopic appendectomy, conventional laparoscopic appendectomy
- Volunteers
- 2 people
- Sponsor
- Mansoura University
Cesarean Section Complications, Cesarean Wound; Dehiscence
PICO Negative Pressure Wound Therapy in Obese Women Undergoing Elective Cesarean Delivery.
A randomized controlled, parallel group, superiority, open-label, single-institution, Phase 3 interventional clinical trial to evaluate clinical outcomes in obese gravidas undergoing elective cesarean delivery whose wounds were…
- Conditions
- Cesarean Section Complications, Cesarean Wound; Dehiscence, Cesarean Wound Disruption
- Trial name
- NCT03414762
- Testing
- PICO Negative Pressure Wound Therapy, Standard Dressing
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Surgery
Operating Room Air Filtration/Sterilization
Determine whether operating room air filtration and sterilization with the ActivePure system reduces a composite of serious surgical site infections, infection-related complications, and death within 30 days after surgery.
- Trial name
- ORACLE (NCT04610294)
- Testing
- Functioning Aerus air filtration/sterilization, Deactivated Aerus air filtration/sterilization
- Where
- United States
- Volunteers
- 66,273 people
- Sponsor
- The Cleveland Clinic
Hypovitaminosis D
Vitamin D Status in Lower Extremity Joint Replacement Surgery Patients
In the United States, ~1 million elective hip or knee replacement surgeries are performed annually. With estimated surgical site infection (SSI) rates as high as 2.5%, this represents ~25,000 patients at risk of potentially…
- Trial name
- NCT01858051
- Testing
- Cholecalciferol
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Surgical Site Infection
ImplementatioN of Remote Surgical wOund Assessment During the coviD-19 pandEmic
This is a implementation research study of a surgical wound tele-monitoring online tool developed at the University of Edinburgh and demonstrated in the "Tracking wound infection with smartphone technology" (TWIST) randomised…
- Trial name
- INROADE (NCT05069103)
- Testing
- Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Incisional Hernia, Abdominal Hernia
Hernia Sac Flap Coverage of Mesh in Bony-Edged Ventral Hernia Repair
This trial asks whether covering the inner, bowel-facing surface of a hernia mesh with a flap of the patient's own hernia sac improves healing after repair of a complex ventral (abdominal wall) hernia in which one edge of the…
- Conditions
- Incisional Hernia, Abdominal Hernia, Complex Ventral Hernia, Surgical Site Infection
- Trial name
- PERI-SAC (NCT07720154)
- Testing
- Sac-flap peritonealization of the mesh, Retromuscular (sublay) synthetic mesh repair
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Pelvic Organ Prolapse, Urinary Incontinence
Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures
This is a randomized controlled trial to determine if there is a difference between chlorhexidine gluconate and povidone iodine vaginal preparations for urogynecological surgery post operative infections.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pelvic Floor Disorders, Gynecologic Disease
- Trial name
- CLNUP (NCT04048356)
- Testing
- Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Surgical Site Infection
Impact of Surgical Site Infection in Peritonitis After Peritoneal Lavage With Super-oxidixed Solution
This is randomised double blinded placebo-controlled parallel-group study. Patients in Hospital Queen Elizabeth, Sabah and Hospital Universiti Sains Malaysia, Kelantan who undergo laparotomy for peritonitis will be equally…
- Trial name
- Plasso 2 (NCT06400394)
- Testing
- Hydrocyn Aqua®, Normal Saline
- Volunteers
- 116 people
- Sponsor
- Universiti Sains Malaysia
Surgical Site Infection, Antibiotic Resistant Infection
Antibiotic Stewardship Program in Pancreatic Surgery: a Multicenter Time Series Analysis (BIOSTEPS).
Rationale: Surgical site infection (SSI) is one of the most frequently reported postoperative complication, occurring in up to one-third of patients.
- Trial name
- BIOSTEPS (NCT04199494)
- Testing
- Antibiotic Stewardship Program
- Where
- 2 sites in Italy
- Volunteers
- 1,200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Surgical Wound Infection
Preoperative Bath in Patients Submitted to Hip Arthroplasty
Clinical trial for prevention, randomized, controlled, blinded, parallel, with three arms which purpose is verify the effects of nursing intervention preoperative bathing with 4% chlorhexidine gluconate, 10% Povidone iodine…
- Trial name
- NCT03001102
- Testing
- 4% Chlorhexidine gluconate, 10% PVPI degermante, Soap without antiseptic
- Where
- Brazil
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Colorectal Surgery
A Single Dose of a Marketed Drug Being Studied for a New Indication to Treat Surgical Site Infection Following Colorectal Surgery as Compared to a Marketed Drug Approved for This Indication (0826-039)
The objective of this study is to evaluate the safety and efficacy of a one time dose of an intravenous marketed drug being evaluated for a new indication as compared to a marketed drug already approved for the prevention of…
- Trial name
- NCT00090272
- Testing
- MK0826, ertapenem sodium, Comparator: cefotetan
- Volunteers
- 952 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Appendicitis, Perforated Gastroduodenal Ulcer
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
Aim of prospective randomized a placebo controlled study is to prove that in case of acute surgical procedure due to appendicitis, ileus of small bowel and perforation of small bowel and stomach appropriately administered…
- Conditions
- Acute Appendicitis, Perforated Gastroduodenal Ulcer, Small Bowel Obstruction
- Trial name
- NCT01524081
- Testing
- Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole
- Where
- Czechia
- Volunteers
- 187 people
- Sponsor
- The Faculty Hospital Na Bulovce
Surgical Site Infection (SSI)
Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions.
- Trial name
- NCT07696819
- Testing
- Levofloxacin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Surgical Wound Infection, Pancreatic Neoplasms
The Use of Wound Protector in Whipple's Procedure With Intrabiliary Stent
Background: There are no published studies regarding the use of wound protectors in the context of surgical site infection (SSI) rates among patients receiving a pancreatoduodenectomy (Whipple) with preoperatively placed…
- Trial name
- NCT01836237
- Testing
- Alexis - a wound protector
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- University of Calgary
Incisional Hernia, Surgical Site Infection
Prophylactic Mesh Reinforcement for Stoma Closure
In the current work we are aiming to compare between the mesh-reinforced stoma closure and the anatomical closure in terms of the risk of developing surgical site incisional hernia (SSIH),incidence of surgical site infection …
- Conditions
- Incisional Hernia, Surgical Site Infection, Postoperative Pain, Hospital Stay, Length of Stay in Hospital From Surgery to Discharge
- Trial name
- OASIS (NCT06157645)
- Testing
- Prolene mesh
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
Gastric Cancer, Surgical Wound Infection
Fatigue and QoL Among Gastric Cancer Patients Undergoing Abdominal Surgery
Background: Cancer-related fatigue (CRF), one of the indicators of QoL, is one of the most common side effects of cancer and its treatment.
- Conditions
- Gastric Cancer, Surgical Wound Infection, Fatigue, Quality of Life
- Trial name
- NCT03766945
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Surgical Wound Infection
Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis
Routine antibiotics for the intravenous and oral prophylaxis of colorectal surgery will be used. Experimental group: Patients undergoing elective colorectal surgery that involves, colonic resection.
- Trial name
- ORALEV (NCT02505581)
- Testing
- Extra dosage - cefuroxime (750mg) I.V, Colorectal Surgery, Ciprofloxacin 750 mg oral
- Where
- 3 sites in Spain
- Volunteers
- 536 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Appendicitis
Single Incision Laparoscopic Appendectomy in the Community Utilizing Conventional Instruments
There is a move to "scarless surgery" and this achieved by doing laparoscopic abdominal surgery though a single small umbilical incision.
- Trial name
- NCT00925145
- Testing
- Single Incision Laparoscopic Appendectomy
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Surgical Site Infection
Impact of Pre-surgical Nasal Bacterial Reduction on Postoperative Surgical Site Infections / Standard Care Change
Patients presenting in the Emergency Department or admitted to the hospital with displaced hip fractures who require hemiarthroplasty or open reduction internal fixation or with spinal instability/fractures in need of urgent…
- Trial name
- NCT01148030
- Testing
- 3M Skin and Nasal Antiseptic
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- 3M