Clinical trials: Incisional Surgical Site Infections
Wound Complication, Surgical Wound Infection
Electrocautery Versus Scalpel for Skin Incisions
The aim of this research project is to compare electrocautery to scalpel for laparotomy skin incisions, with the following objectives: 1. To investigate whether electrocautery produces a cosmetically inferior surgical scar. 2.
- Conditions
- Wound Complication, Surgical Wound Infection, Post-operative Pain
- Trial name
- NCT01496404
- Testing
- Electrocautery, Scalpel
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- St. Paul's Hospital, Canada
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Laparotomy, Dehiscence Wound
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory…
- Conditions
- Laparotomy, Dehiscence Wound, Surgical Site Infections, Trauma Abdomen
- Trial name
- NCT06043414
- Testing
- triclosan-coated barbed suture, triclosan-coated non-barbed suture, Non-coated non-barbed suture
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Southern California
Cesarean Section, Surgical Site Infection
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Trial name
- STRIP-CS (NCT07686913)
- Testing
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Riverside University Health System Medical Center
Surgical Site Infections, Gastric Cancer
Povidone-iodine and the Normal Saline Cleaning the Incision for the SSIs
Surgical site infections (SSIs) is one of the most common complications of upper abdominal surgery. Previous studies found that type of surgical incision, emergency operation or not, surgical duration, age of patient, body mass…
- Conditions
- Surgical Site Infections, Gastric Cancer, Dehiscence of Laparotomy Wound
- Trial name
- NCT02436395
- Testing
- Group A (povidone-iodine wash the surgical incision), Group B (normal saline wash the surgical incision)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- West China Hospital
Obesity, Diabetes
Effects of Prevena Therapy on Obese and or Diabetic Patients With Surgical Groin Sites
The purpose of the study is to determine the effects of Prevena therapy on decreasing groin surgical site infections in patients who are obese and /or diabetic having vascular surgery.
- Conditions
- Obesity, Diabetes, Peripheral Vascular Disease
- Trial name
- NCT01983215
- Testing
- Prevena vac
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Dr. Jean E. Starr, MD
Surgical Wound, Surgical Site Infection
Clinical Assessment of Next Science Wound Gels in Healing Below the Knee Amputation Surgical Wound Compared to SOC
This is a 64-patient, 90-day, open -label study on adult patients undergoing below knee amputation for various etiologies. The objective of this study is to assess surgical wound healing and wound bioburden using combination…
- Conditions
- Surgical Wound, Surgical Site Infection, Surgical Wound Infection, Amputation Stump; Infection
- Trial name
- NCT04053946
- Testing
- Next Science Wounds Gels
- Sponsor
- Next Science TM
Bacterial Translocation, Surgical Site Infection
Plastic Wound Retractors and Bacterial Translocation in Abdominal Surgery
Hypothesis: Plastic wound retractors reduce passage of bacteria from the abdomen to the surgical incision site in abdominal surgery Currently, plastic wound retractors are used in abdominal surgery to facilitate access to the…
- Conditions
- Bacterial Translocation, Surgical Site Infection, Abdominal Surgery, Wound Infection
- Trial name
- NCT01007487
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- St Vincent's University Hospital, Ireland
Complications; Cesarean Section, Surgical Wound Infection
Subcuticular Suture for Cesarean Skin Incision Closure
A comparison of the type of suture used for cesarean skin incision approximation and the subsequent rate of wound complications has not been widely studied.
- Trial name
- NCT02459093
- Testing
- poliglecaprone 25 suture, polyglactin 910 suture
- Where
- 2 sites in United States
- Volunteers
- 550 people
- Sponsor
- Montefiore Medical Center
Incisional Surgical Site Infections
Total Occlusive Ionic Silver-containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection
The patients were randomized into 3 groups: those patients undergoing a ionic silver-containing dressing (ISD) (Group 1), those undergoing a Mupirocin ointment application (MOA) (Group 2) and those using a conventional dressing…
- Trial name
- NCT02267122
- Testing
- ionic silver-containing dressing, Mupirocin ointment application
- Volunteers
- 147 people
- Sponsor
- Hospital General Universitario Elche
Postoperative Wound Infection Superficial Incisional, Postoperative Wound Infection Deep Incisional Surgical Site
Is the NPWTi Better Than the Conventional NPWT
The goal of this clinical trial is to compare the effectiveness of NPWTi and NPWT in superficial and deep surgical site infections using an improvised system with continuous lavage with saline and chlorhexidine.
- Trial name
- NCT06014788
- Testing
- NPWTi, Conventional NPWT
- Where
- Bulgaria
- Volunteers
- 100 people
- Sponsor
- Military Medical Academy, Bulgaria
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
Wound Infection, Cicatrization
Comparison of the Impact of Electric Scalpels Versus Cold Scalpels
Surgical site infection (SSI) is the second commonest hospital infection, despite advances in prevention that have been achieved.
- Trial name
- SCL01 (NCT01410175)
- Testing
- Conventional scalpel
- Where
- Brazil
- Volunteers
- 163 people
- Sponsor
- Barretos Cancer Hospital
Surgical Site Infection
Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation
A surgical site infection (SSI) is an infection that occurs after a surgical procedure. Despite a variety of infection prevention strategies, SSIs still occur often and impose a significant burden on patients and the healthcare…
- Trial name
- NCT04548661
- Testing
- Intraoperative incisional wound irrigation with povidone-iodine solution, Intraoperative incisional wound irrigation with saline
- Where
- 13 sites in Canada
- Volunteers
- 2,701 people
- Sponsor
- Sunnybrook Health Sciences Centre
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Appendicitis
A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy.
LESS laparoscopic appendectomy is associated with less pain than conventional 3-port laparoscopic appendectomy.
- Trial name
- NCT01203566
- Testing
- LESS appendectomy, Conventional 3-port laparoscopic appendectomy
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Incisional Hernia/Prevention and Control, Surgical Site Infection (SSI)
Comparison of Small-bite Versus Conventional Midline Fascial Closure in Abdominal Surgeries
This study investigates how different incision and fascial closure (suture) techniques used in abdominal surgery are associated with the development of incisional hernia, a common long-term complication after laparotomy.
- Trial name
- NCT07340918
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Colorectal Surgery
Prospective, Randomized, Parallel-arm Clinical Trial of CleanCision or Alexis O in Elective Colorectal Surgery
Surgical site infection (SSI) remains a problem in colorectal surgery. Strategies to reduce the incidence of SSI following colorectal surgery are important to improve overall patient outcomes, reduce healthcare-associated costs…
- Trial name
- NCT03816995
- Testing
- CleanCision Wound Retraction and Protection System, Alexis O Wound Protector
- Where
- United States
- Volunteers
- 702 people
- Sponsor
- Scott Steele
Chronic Pain, Wound Dehiscence
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy.
- Conditions
- Chronic Pain, Wound Dehiscence, Surgical Site Infection (SSI), Incisional Hernia
- Trial name
- PolySuture (NCT07280975)
- Testing
- Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture
- Where
- Pakistan
- Volunteers
- 156 people
- Sponsor
- Lady Reading Hospital, Pakistan
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital