Clinical trials: Incretins
Healthy Adult Volunteers
Intestinal Ketone Bodies Interfere With the Glycemic Control
The ketone body (KB) ß-hydroxybutyrate will be given to eight fasting healthy volunteers of both sexes in order to observe the effects after an oral glucose tolerance test (OGTT) over 2 h.
- Trial name
- NCT05154461
- Testing
- Alginate, Pea-protein
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Type 2 Diabetes, Obesity
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI > 35 kg/m2).
- Trial name
- GIP-PET (NCT01880827)
- Testing
- Roux-en-Y, GIP-infusion, GLP-1
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Polycystic Ovary Syndrome
Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)
The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose.
- Trial name
- NCT00647023
- Testing
- metformin
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Type 2 Diabetes
Insulinotropic Effect of GLP-1 and GIP After Dexamethasone
In this study we examine whether inducing insulin resistance by dexamethasone in healthy volunteers will lead to a decreased insulinotropic effect of the hormones GLP-1 and GIP.
- Trial name
- NCT02235584
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cardiovascular Diseases
Elucidating the High Cardiovascular Disease Risk in South Asians
The goals of this cross-sectional study are to compare immune cell composition and release of incretin hormones following a meal in healthy Dutch South Asians and Dutch Europids.
- Trial name
- CAMI (NCT05829018)
- Testing
- Mixed meal test
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Type 2 Diabetes
Dissection of the Gastrointestinal-mediated Glucose Disposal and Incretin Defect in Patients With Type 2 Diabetes
In patients with type 2 diabetes, the incretin effect is markedly reduced contributing to the relative insulin deficiency that characterizes these patients.
- Trial name
- NCT02669524
- Testing
- LY2409021, OGTT, IIGI
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type2 Diabetes Mellitus, Obesity
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation
Several free fatty acids receptors (FFARs) have been discovered. These have been implicated in metabolic processes and inflammation.
- Trial name
- NCT03062592
- Testing
- Pine nut oil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Obesity
Peripheral Pharmacodynamics of Phentermine-Topiramate in Obese Patients
Our overall goal is to determine the effect of Phentermine and Topiramate ER on gastric emptying, gastric accommodation, satiety, and satiation in obese participants.
- Trial name
- NCT01834404
- Testing
- Phentermine-Topiramate ER
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Insulin Sensitivity, Glucose Tolerance
Effect of Camel Milk on Insulin and Incretin Response
To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
- Trial name
- NCT03725969
- Testing
- Camel milk, Cow milk
- Where
- United Arab Emirates
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
GLP-1, Gut Microbiota
Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1
Recently, it has been proposed that the consumption of non-nutritive sweeteners, including sucralose, it's not harmless and is related with metabolic effects.
- Conditions
- GLP-1, Gut Microbiota, Insulin Resistance
- Trial name
- NCT06094894
- Testing
- sucralose
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
GLP-1, Obesity &Amp; Overweight
Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults
Obesity is a chronic condition linked to numerous health risks and affects more than one billion people worldwide. While pharmacological treatments such as incretin-based therapies are available, they may have side effects, are…
- Conditions
- GLP-1, Obesity &Amp; Overweight, Dietary Supplement
- Trial name
- NCT07240246
- Testing
- Intervention: Dietary Supplement with Plant Extracts
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation
Incretin Effect
The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function
This project will characterize the physiological effect of the hormones, GIP-, GLP-1- and GLP-2 infusions in a group of individuals that are carriers of GIP-, GLP-1- and GLP-2 receptor gene variants, respectively.
- Trial name
- H-21044858 (NCT06194955)
- Testing
- GIP(1-42), GLP-1, GLP-2
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 2 Diabetes, Ageing
Effects of Nitrate on Liver Perfusion and Sugar Control
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich in nitrate.
- Trial name
- DiMPLe (NCT02195856)
- Testing
- Beetroot juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Insulin Resistance, Glucose Intolerance
Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect
The purpose of this study is to examine whether there is a causal relationship between insulin resistance and/or glucose intolerance in the development of a defect incretin effect.
- Trial name
- NCT00784745
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Caloric Restriction, Body Composition
Short Term Effects of Semaglutide on Body Composition and Performance
Semaglutide, a GLP-1 receptor agonist, has demonstrated significant weight-loss effects in people with obesity and/or type 2 diabetes, but its impact on exercise performance among lean, fit athletes remains unknown.
- Conditions
- Caloric Restriction, Body Composition, Performance
- Trial name
- NCT07874971
- Testing
- Semaglutide (SEMA)
- Where
- Denmark
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Obesity
Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.
The purpose of this study is to investigate the effects of intravenous infusion of two gastrointestinal hormones, PYY3-36 and GLP-1, alone and in combination, on appetite in healthy obese men.
- Trial name
- INGEAR-1 (NCT00940134)
- Testing
- PYY 3-36, GLP-1, saline infusion
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Sugar-replacement Sweeteners, and Blood Sugar Control
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda).
- Trial name
- SIR (NCT01128829)
- Testing
- Water, Sucralose
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes, Obesity
Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy
The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis.
- Trial name
- NCT01820273
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lund University