Clinical trials: Incretins
Bariatric Surgery
Understanding Hypoglycaemia After Bariatric Surgery
Postprandial hyperinsulinaemic hypoglycaemia is an increasingly recognized adverse side effect of bariatric surgery. Affected individuals experience low glucose levels 1-3 hours after intake of meals, accompanied by symptoms such…
- Trial name
- HYPOBAR1 (NCT03609632)
- Testing
- Dietary Supplement: Glucose
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
ESRD
Glucose Metabolism During Hemodialysis
Disturbed glucose metabolism is a common feature of patients with end-stage renal disease (ESRD). Several hormones responsible of a stable blood glucose including insulin, glucagon, and the gastrointestinal insulinotropic…
- Trial name
- NCT01800188
- Testing
- Hemodialysis, Hemodiafiltration, Meal test
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Bo Feldt-Rasmussen
Familial Renal Glucosuria, Diabetes Mellitus
Human Solute Carrier Family 5 Member 2 (SLC5A2) Deficiency and the Glucagon-Incretin Axis
Sodium-glucose-cotransporter 2 (SGLT2) are a new type of oral antidiabetic drugs. SGLT2 inhibitors increase the urinary glucose excretion and thereby decrease blood glucose levels.
- Conditions
- Familial Renal Glucosuria, Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- NCT03965000
- Testing
- Mixed-meal-tolerance-test
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Healthy Volunteers Recruited From the General Population
Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers
To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers
- Trial name
- NCT01779622
- Testing
- Mixed meal
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lund University
Diabetes Mellitus, Iron Metabolism Disorders
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
Patients who are genetically diagnosed with the recently reported and rare Wolfram syndrome type 2 ( WFS2) and have the degenerative and symptomatic disease including signs such as diabetes, platelet aggregation defect or visual…
- Conditions
- Diabetes Mellitus, Iron Metabolism Disorders, Gastroduodenal Ulcer, Optic Atrophy
- Trial name
- NCT02882477
- Testing
- Deferiprone, Acetylcysteine, Sitagliptin and Metformin
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Diabetes Mellitus, Type 2
Effects of Dapagliflozin on the Incretin Sensitivity of the Pancreatic Beta Cell
To investigate the effect of dapagliflozin on the incretin sensitivity of the pancreatic beta cell.
- Trial name
- NCT02420392
- Testing
- Dapagliflozin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Type 2 Diabetes, Overweight
The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
The aim of this study is to evaluate the effect of glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes.
- Conditions
- Type 2 Diabetes, Overweight, Disordered Eating Behaviors
- Trial name
- NCT06243536
- Testing
- Semaglutide, standard of care
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Sestre Milosrdnice
Morbid Obesity, Metabolic Syndrome X
Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Bariatric surgery is the most effective treatment for morbid obesity. Roux-en-Y gastric bypass (RYGB) is a bariatric procedure with known safety and effectiveness.
- Conditions
- Morbid Obesity, Metabolic Syndrome X, Diabetes Mellitus, Dyslipidemia
- Trial name
- NCT01806506
- Testing
- Laparoscopic sleeve gastrectomy, Roux-en-Y Gastric Bypass
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus, Cardiovascular Diseases
Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)
This study used the diabetes prevention and follow-up research queue in Daqing and the public database of UKbiobank to evaluate the risk factors of cardiovascular and cerebrovascular events in diabetes patients, and built the…
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Cerebrovascular Disease
- Trial name
- NCT06959784
- Testing
- semaglutide, Metformin
- Where
- China
- Volunteers
- 142 people
- Sponsor
- China-Japan Friendship Hospital
Obesity, Overweight and Obesity
A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight
The main purpose of this study, performed under a master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with Mazdutide compared with placebo and in adult participants with obesity or…
- Trial name
- NCT06124807
- Testing
- Mazdutide
- Where
- 29 sites in United States
- Volunteers
- 179 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Hypoglycemia
Neuronostatin - a Glucagonotropic Agent in Humans?
With the present study the investigators wish to delineate the effects of neuronostatin-13 (NST) on glucose-dependent glucagon secretion in humans.
- Conditions
- Type 1 Diabetes, Hypoglycemia, Type1diabetes
- Trial name
- NSTCLAMP (NCT06143267)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity and Obesity-related Medical Conditions
Weight Changes After Incretin-mimetics
The goal of this study is to identify people at risk of weight regain after stopping an injectable weight loss drug. The main question the investigators aim to answer is: Can weight regain be predicted by measuring circulating…
- Trial name
- NCT06795360
- Testing
- discontinuation of weight loss medication
- Volunteers
- 52 people
- Sponsor
- Medical College of Wisconsin
Type 2 Diabetes Mellitus
Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial
This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients.
- Trial name
- NATRIURETIC (NCT04535960)
- Testing
- Empagliflozin 25 MG + Liraglutide 1.8 MG, Liraglutide 1.8 MG + Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Obesity
Circulating Microvesicles Regulating Metabolic Homeostasis in Obesity After Caloric Restriction Programs
The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating…
- Trial name
- TREV (NCT06395246)
- Testing
- Active Comparator: Continuous calorie restriction, eTRE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Morbid Obesity
Bariatric Procedures and Changes in Incretins and Gastric Emptying
The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the…
- Trial name
- BIG (NCT02539641)
- Testing
- Gastric emptying scintigraphy, Determination of gut hormones
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Rijnstate Hospital
Healthy Male Adults
Testing the Potential Metabolic Effect of the Human Gut Bacterial Peptide, RUCILP, in Healthy Men
The goal of this randomized, double-blinded and placebo-controlled clinical cross-over trial is in healthy men to explore the potential metabolic effects of the naturally occurring gut bacterial polypeptide, RUCILP.
- Trial name
- NCT06923839
- Testing
- Test bacterial peptide: RUCILP
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oluf Pedersen
Steatosis of Liver, Metabolic Liver Injury
Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity
This single-center, retrospective observational cohort study evaluated early changes in non-invasive hepatic and metabolic indices (FIB-4, APRI, HSI, and the triglyceride-glucose [TyG] index) in adults with overweight or obesity…
- Conditions
- Steatosis of Liver, Metabolic Liver Injury, Obesity, Overweight
- Trial name
- GLP-NIT (NCT07701005)
- Testing
- Semaglutide, Tirzepatide
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Type 2 Diabetes Mellitus
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.
- Trial name
- SURPASS-CVOT (NCT04255433)
- Testing
- Tirzepatide, Dulaglutide
- Where
- 635 sites in United States, Argentina and 29 more
- Volunteers
- 13,299 people
- Sponsor
- Eli Lilly and Company
Cystic Fibrosis, Pancreatic Insufficiency
Effect of Chronic Incretin-based Therapy in Cystic Fibrosis
In recent years, diabetes has emerged as one of the most significant co-diseases that many Cystic Fibrosis (CF) patients develop.
- Trial name
- NCT01879228
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 1, Hypoglycemia
The Role of Glucose-Dependent Insulinotropic Polypeptide in the Pathological Glucose Homeostasis Of Type 1 Diabetes
In the present project the investigators will evaluate whether glucagonotropic properties of the gut-derived incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may be utilized as a safeguard against hypoglycemia…
- Trial name
- NCT03734718
- Testing
- GIP
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Steno Diabetes Center Copenhagen