Clinical trials: Indigestion
Heartburn, Indigestion
A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants
Researchers are looking for a better way to treat people who have heartburn, indigestion, and problems due to excessive stomach acid. These are common problems which can affect daily life and disturb sleep during the night-time.
- Conditions
- Heartburn, Indigestion, Stomach Acid Related Symptoms, Nocturnal Stomach Acid Related Symptoms
- Trial name
- NCT06293326
- Testing
- bi-layer calcium carbonate tablet (BAY1180654), Immediate release calcium carbonate tablet (BAY1180654)
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bayer
Functional Dyspepsia, Postprandial Distress Syndrome
Acupuncture for Patients With Function Dyspepsia
Hypothesis: Acupuncture is efficacious and safe for patients with functional dyspepsia Design: A single blind randomized controlled trial 200 participants will be included Two arms: acupuncture and sham acupuncture group
- Trial name
- NCT01671670
- Testing
- acupuncture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Non Ulcer Dyspepsia
Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia
The purpose of this study is to determine if use of Nortriptyline will improve symptoms and quality of life in patients who have nonulcer dyspepsia.
- Trial name
- NCT00547703
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Cleveland Clinic
Functional Dyspepsia, Scarred Peptic Ulcer
Empirical Rescue Therapies of Helicobacter Pylori Infection
The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare.
- Trial name
- NCT01668927
- Testing
- Proton Pump Inhibitor, Bismuth, Metronidazole
- Where
- China
- Volunteers
- 424 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Gastroesophageal Reflux, Dyspepsia
Effects of Diet on Reflux and Dyspepsia
Reflux and dyspeptic symptoms are common affecting 10-20% of the population on a regular basis. Reflux symptoms such as heartburn and regurgitation are caused by the return of acid or non-acid gastric contents into the esophagus.
- Trial name
- NCT02425553
- Testing
- Diet
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Functional Gastrointestinal Disorders
The Association of Clinical Symptom Clusters With Underlying Mechanisms in Functional Gastrointestinal Disorders
Functional gastrointestinal disorders (FGID) are amongst the most common causes of abdominal pain and dysfunction seen in clinical practice, affecting between 10 to 15% of most populations (1).
- Trial name
- NCT04331223
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- Brain-Gut Research Group
Dyspepsia
Serotonin Effect in Functional Dyspepsia
The purpose of this study is to investigate whether Efexor (venlafaxine) is effective in the treatment of functional dyspepsia.
- Trial name
- NCT00115362
- Testing
- venlafaxine
- Where
- 6 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Radboud University Medical Center
Helicobacter Pylori Infection
Efficacy and Safety of Lacidofil® STRONG as an Adjuvant for Helicobacter Pylori Treatment in Non-ulcer Dyspepsia
Treatment for H. pylori eradication includes antibiotics. The treatment has decreased its efficiency (lower capability to eradicate the infection) due to increasing antibiotic resistance in the population.
- Trial name
- NCT04473079
- Testing
- Lacidofil
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Lallemand Health Solutions
Dyspepsia
Change of Gut Microbiome and Symptom After H.Pylori Eradication Therapy in Patients With Functional Dyspepsia
The aims of the investigators' study are to investigate the effect of H.pylori eradication on the human gut microbiome and symptoms of functional dyspepsia.
- Trial name
- NCT04449185
- Testing
- Tegoprazan 50mg bid + amoxicillin 1000mg bid + clarithromycin 500mg bid for 10 days
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Dyspepsia, Heartburn
Mipolixin® Compared to Poliprotect® in Moderate Functional Dyspepsia and Heartburn.
Evaluation of the clinical efficacy of two medical devices, Mipolixin® and Poliprotect®, in improving the overall symptom severity of functional dyspesia and/or heartburn
- Trial name
- NCT03531372
- Testing
- Mipolixin®, Poliprotect®
- Where
- 11 sites in Spain
- Volunteers
- 158 people
- Sponsor
- Aboca Spa Societa' Agricola
Functional Dyspepsia
Mirtazapine Versus Placebo in Functional Dyspepsia
Double-blind randomized controlled trials of 8 weeks mirtazapine 15 mg daily or placebo, followed by 8 weeks of open-label mirtazapine 15 mg daily
- Trial name
- NCT01240096
- Testing
- Mirtazapine
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dyspepsia and Other Specified Disorders of Function of Stomach
Functional Dyspepsia Treatment Trial
Functional dyspepsia is a common gastrointestinal disorder. Symptoms can include stomach pain or discomfort, bloating, fullness after eating meals, and nausea.
- Trial name
- FDTT (NCT00248651)
- Testing
- Amitriptyline, Escitalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 292 people
- Sponsor
- Mayo Clinic
Functional Dyspepsia
Efficacy of Banhasasim-tang on Functional Dyspepsia
The purpose of this study is to assess efficacy based on Gastrointestinal Symptom score and safety based on the rate of adverse event or laboratory findings of Banhasasim-tang administrated three times a day orally on functional…
- Trial name
- NCT00987805
- Testing
- Banhasasim-tang, Corn-starch granules
- Where
- 2 sites in South Korea
- Volunteers
- 84 people
- Sponsor
- Korea Health Industry Development Institute
Heartburn, Dyspepsia
Primary carE PPi dEprescRibing Trial
Proton pump inibitors (PPIs) is a class of medications that reduce the acid secretion in the stomach. These medications are very effective to relieve symptoms of acid reflux for a well-identified group of diseases and conditions.
- Conditions
- Heartburn, Dyspepsia, Reflux
- Trial name
- PEPPER (NCT05629143)
- Testing
- de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate
- Where
- Belgium
- Volunteers
- 724 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Psychogenic Dyspepsia
Clinical Improvement and in Quality of Life-Functional Dyspepsia-
Functional dyspepsia (FD)is defined as the presence of symptoms thought to originate in the gastroduodenal region with no evidence of structural disease that is likely to explain the symptoms.
- Trial name
- NCT01802710
- Testing
- Psychological support, No intervention
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Hospital Galdakao-Usansolo
Nonulcer Dyspepsia
The Efficacy of Pantoprazole Treatment in Patients With Functional Dyspepsia
The aim of our study is to evaluate the effectiveness of proton pump inhibitor (PPI) treatment in patients with functional dyspepsia.
- Trial name
- NCT01608750
- Testing
- Pantoprazol, Folic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bezmialem Vakif University
Functional Dyspepsia
Clinical Course of Functional Dyspepsia and Factors Predicting Outcome in Patients Receiving Medication-based Treatment
Functional dyspepsia (FD) is one of most common chronic gastrointestinal disorders. Several types of drugs were demonstrated to be effective in reduction or remission of symptoms and severity of FD, including proton pump…
- Trial name
- NCT05513040
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Air Force Military Medical University, China
Sedative During Endoscopy
Implementing Virtual Reality (VR) to Reduce Sedation
The study is a prospective pilot patients aged 21 to 65 undergoing screening colonoscopy or diagnostic upper endoscopy. Patients are administered minimal sedation (2 mg of Versed and 25 mg of Fentanyl) and are given Virtual…
- Trial name
- NCT06349564
- Testing
- Pico 4 Enterprise headset with noise cancelling headphones
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Functional Dyspepsia
Acupuncture of Different Treatment Frequency on Improving Quality of Life in Patients With Functional Dyspepsia
The objective of this trial is to assess acupuncture of different treatment frequency on improving quality of life in patients with functional dyspepsia.
- Trial name
- NCT04548011
- Testing
- Acupuncture
- Volunteers
- 60 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Duodenal Ulcer, Gastric Ulcer
Lymphocytic Subsets and Cytokine Production With H. Pylori Infection
The aims of this study are 1) to determine the cytokines produced by both Th1 and Th2 subsets in gastric antral biopsy specimens from Taiwanese patients before and after anti H.
- Conditions
- Duodenal Ulcer, Gastric Ulcer, Dyspepsia
- Trial name
- NCT00173953
- Testing
- immune response
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital