Clinical trials: Individual Difference
Depressive Disorder, Major
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
This study is open to adults with depression (major depressive disorder) for whom standard treatment with antidepressants alone does not work sufficiently.
- Trial name
- NCT04521478
- Testing
- BI 1358894, Quetiapine
- Where
- 120 sites in United States, Argentina and 12 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Peripheral Facial Paralysis, Facial Palsy
Functional Recovery From Facial Paralysis
This is a controlled, single-blind (hybrid) clinical investigation that aims to analyze the process of recovery of muscle function in people with peripheral facial paralysis who receive kinesthetic treatment with…
- Conditions
- Peripheral Facial Paralysis, Facial Palsy, Synkineses
- Trial name
- NCT06532903
- Testing
- Selective muscle electrostimulation with exponential current, Facial muscle reeducation in front of the mirror
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Universidad Nacional del Nordeste, Argentina
Healthy Volunteers
Impact of Different Face Masks on Maximal and Submaximal Performance Testing During COVID-19
In COVID 19, masks wearability has become a new normal and this "new normal" presented evidence-based performance limitations. The study findings are aimed to objectify parametric changes (if any) and therefore, will assist in…
- Trial name
- NCT05150613
- Testing
- No Mask, Surgical Mask, N95 Mask
- Where
- 2 sites in Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Multiple Sclerosis
Step it Up: An Exercise and Behaviour Change Programme for People With Multiple Sclerosis
Exercise has consistently yielded short-term, positive effects on health outcomes in people with multiple sclerosis (MS). However, these effects have not been maintained in the long-term.
- Trial name
- NCT02301442
- Testing
- Exercise + behaviour change intervention, Exercise + control education
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- University of Limerick
CLBP - Chronic Low Back Pain
Effect Virtual Reality Fully Immersive Based Exercise Game on Reducing Fear of Movement in People With CLBP
Low back pain is one of the most common problems among adults and a leading cause of disability worldwide including in Saudi Arabia (Buchbinder et al., 2018) (Awaji, 2016) .
- Trial name
- NCT05267756
- Testing
- (kurki-application),VR glasses
- Where
- Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- King Saud University
Coronavirus
Clinical Study of Recombinant Novel Coronavirus Vaccine
A total of 900 subjects are planned to be randomly divided into 2 doses of low-dose experimental vaccine group, 2 doses of high-dose experimental vaccine group, 2 doses of placebo group, 3 doses of low-dose experimental vaccine…
- Trial name
- NCT04466085
- Testing
- Recombinant new coronavirus vaccine (CHO cell) low-dose group, Recombinant new coronavirus vaccine (CHO cells) high-dose group
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Parkinson's Disease
Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease
The purpose of this study is to assess the feasibility, in regards to acceptability and implementation, of the Pre-Active PD intervention for increased high intensity goal-directed aerobic exercise engagement in people with…
- Trial name
- Preactive-PD (NCT03696589)
- Testing
- Physical Activity Coaching
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Teachers College, Columbia University
Solid Tumors, KRAS Mutation
A Study to Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation
This study is open to adults with different types of advanced or metastatic cancer (including lung cancer, colorectal cancer, pancreatic cancer, and bile duct cancer).
- Trial name
- NCT04973163
- Testing
- BI 1823911, BI 1701963, Midazolam
- Where
- 9 sites in United States, Belgium and 2 more
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Verticality Perception in Healthy Human Subjects, Individual Contribution of Different Sensory Systems
Verticality Perception - Multisensory Contribution
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects.
- Trial name
- NCT02212704
- Testing
- Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk), 3D-video-head impulse testing, Vestibular-evoked myogenic potentials (VEMPs)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy, Liver Diseases
A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906
This study is open to adults who have different levels of liver problems and adults who are healthy. People with or without overweight or obesity can take part. This study has 2 parts.
- Conditions
- Healthy, Liver Diseases, Obesity
- Trial name
- NCT05296733
- Testing
- BI 456906
- Where
- 13 sites in United States, Germany and 4 more
- Volunteers
- 82 people
- Sponsor
- Boehringer Ingelheim
Physical Activity, Behavior Change
Individual and Environmental Mechanisms of PA Change
The focus of this study is to determine the mechanisms that underlie Physical Activity behavior change. We have 2 primary objectives.
- Trial name
- NCT00432133
- Testing
- Protection Motivation Theory-Based Intervention, Environmenta
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Healthy
A Study to Test How Different Doses of BI 3814916 Are Tolerated by Healthy People
The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics (PK) of BI 3814916 in healthy male and female trial participants.
- Trial name
- NCT07486115
- Testing
- BI 3814916
- Where
- Belgium
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Kidney Disease, Chronic
A Study to Test Whether Different Doses of BI 690517 Alone or in Combination With Empagliflozin Improve Kidney Function in People With Chronic Kidney Disease
This study is open to adults with chronic kidney disease. People with and without type 2 diabetes can take part in this study. The purpose of this study is to find out whether a medicine called BI 690517 improves kidney function…
- Trial name
- NCT05182840
- Testing
- BI 690517, Empagliflozin
- Where
- 203 sites in United States, Argentina and 27 more
- Volunteers
- 714 people
- Sponsor
- Boehringer Ingelheim
Multiple Sclerosis
Physical Activity Intervention for Individuals Newly Diagnosed With MS
The proposed study is a parallel-group randomized controlled trial (RCT) designed to establish the behavioral mechanism underlying a 16-week physical activity (PA) behavioral intervention through its effects on the…
- Trial name
- ActivNMS (NCT07731659)
- Testing
- COM-B-based Physical Activity Behavior Change Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Advanced Relapsed or Refractory Germ Cell Tumours, Advanced Relapsed or Refractory Endometrial Cancer
A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)
This study is open to adults with advanced germ cell tumours, endometrial cancer, or ovarian cancer whose previous treatments were not successful.
- Conditions
- Advanced Relapsed or Refractory Germ Cell Tumours, Advanced Relapsed or Refractory Endometrial Cancer, Advanced Relapsed or Refractory Ovarian Cancer
- Trial name
- NCT07306559
- Testing
- BI 3820768
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 187 people
- Sponsor
- Boehringer Ingelheim
Bronchiectasis, Quality of Life
A Series of N-of-1 Trials of Traditional Chinese Medicine Based on Bayesian Method
The guiding role of parallel randomized controlled trials in clinical practice is limited due to the insufficiency of individual information.
- Conditions
- Bronchiectasis, Quality of Life, Traditional Chinese Medicine, Sputum
- Trial name
- NCT04601792
- Testing
- Individualized Decoction, Tested drug minus heat-clearing herbs
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Individuality, Self-Efficacy
Effects of Individual and Group Occupational Therapy on General Self-Efficacy, Psychological Well-Being, Personal Independence and Occupational Therapy in Older Adults
The objective of this study is to determine whether individual and/or group occupational therapy leads to changes in generalized self-efficacy and psychological well-being, and to identify the type of therapy that has the best…
- Conditions
- Individuality, Self-Efficacy, Well-being
- Trial name
- NCT02906306
- Testing
- Individual Occupational Therapy, Group Occupational Therapy
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- University of Malaga
Cerebral Palsy
Different Virtual Reality Devices in People With Cerebral Palsy
A computer program was developed with the same task, but with two possibilities of user interaction: a) interface with contact: in which the individual touches the computer screen to finish the task and b) interface without…
- Trial name
- NCT03352440
- Testing
- Cerebral Palsy - Kinect, Cerebral Palsy - Touchscreen, Control Group - Kinect
- Where
- Brazil
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Physical Activity
Investigations of the Effects and Associated Neural Mechanisms of Different Exercise in People With Metabolic Syndrome
Metabolic syndrome (MetS) is a risk for many chronic diseases of middle-aged and older adults. Hence, prevention and treatment of MetS is a crucial global health issue.
- Trial name
- NCT05672940
- Testing
- Aerobic plus resistance training, Stretching plus breathing training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Overweight and Obesity
A Theory-based Digital Intervention to Promote Weight Loss and Weight Loss Maintenance
Obesity can severely reduce quality and longevity of life and there is an urgent need to help people lose weight and maintain weight loss long term.
- Trial name
- NCT04291482
- Testing
- Choosing Health Intervention, Choosing Health Control
- Where
- Poland
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw