Clinical trials: Induced Labor
Induced Labor, Cervical Ripening
Safety and Feasibility of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induced Labor, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SENPe (NCT07846111)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aalto University
Labor Pain, Induced; Birth
Intracervical Balloon Placement With Nitrous Oxide Administration
This randomized controlled trial aims to compare the effectiveness of nitrous oxide versus oxygen in facilitating the successful placement of a Foley balloon catheter for cervical ripening and induction of labor.
- Trial name
- NCT06498908
- Testing
- Nitrous oxide, Oxygen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jefferson Drapkin
Labor, Pelvic Floor Disorder
Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome
Pregnancy and vaginal birth are the main causes of pelvic floor disorders such as urinary incontinence and pelvic organ prolapse.
- Conditions
- Labor, Pelvic Floor Disorder, Labor Stage, Second, Induced Labor
- Trial name
- LEVATOR-IOL (NCT07797387)
- Testing
- Three-dimensional transperineal pelvic floor ultrasound
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Labor, Induced
Mifepristone Outpatient Labour Induction
The number of women having an induction of labour is increasing and is currently used in 33% of pregnancies for a range of medical reasons.
- Trial name
- MOLI (NCT05177510)
- Testing
- Mifepristone
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Labor, Induced, Term Pregnancy
Comparison of Vaginal PGE2 (Dinoprostone) and Vaginal Misoprostol for Induction of Labour in Primigravid Term Pregnancy
This randomized controlled trial was conducted to compare vaginal misoprostol and vaginal PGE2 (dinoprostone) for induction of labour in primigravid women with term pregnancy.
- Conditions
- Labor, Induced, Term Pregnancy, Cervical Ripening
- Trial name
- NCT07559812
- Testing
- Misoprostol, Dinoprostone 3 mg
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- Mayo Hospital Lahore
Labor, Induced, Cervical Ripening
Membrane Stripping for Cervical Ripening
The goal of this interventional study is to evaluate the effectiveness of membrane stripping in cervical ripening compared to double balloon catheter induction. The study population consists of women undergoing labor induction.
- Conditions
- Labor, Induced, Cervical Ripening, Balloon Induction, Membrane Stripping
- Trial name
- Stripping (NCT06591247)
- Testing
- Double Baloon Catheter, Membrane Stripping, PGE2
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Premature Rupture of Fetal Membranes, Labor, Induced
PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM).
- Conditions
- Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening
- Trial name
- POXY-PROM (NCT07366359)
- Testing
- Sequential Induction: Dinoprostone Followed by Oxytocin, Immediate Oxytocin Induction
- Where
- Vietnam
- Volunteers
- 450 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Labor, Induced
Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter
This prospective, randomized, double-blind controlled trial aims to evaluate whether intravenous papaverine, administered immediately after the removal of a double-balloon catheter used for cervical ripening, can shorten the…
- Trial name
- NCT07237880
- Testing
- Papaverine 80 mg IV
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Preeclampsia, Obstetric Labor Complications
Pravastatin to Prevent Preeclampsia
This study is a double-blind randomized placebo-controlled trial of 1,550 high-risk women to assess whether daily treatment with pravastatin administered early in pregnancy reduces the rate of a composite outcome of preeclampsia…
- Conditions
- Preeclampsia, Obstetric Labor Complications, Hypertension in Pregnancy
- Trial name
- Pravastatin (NCT03944512)
- Testing
- Pravastatin
- Where
- 12 sites in United States
- Volunteers
- 102 people
- Sponsor
- The George Washington University Biostatistics Center
Labor, Induced, Labor, Obstetric
Maternal Informing on Labor Induction: Impact on Childbirth Experience
The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience.
- Conditions
- Labor, Induced, Labor, Obstetric, Pregnancy, Humans
- Trial name
- NCT07272785
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Labor, Induced
Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)
The goal of this RCT is to learn if application of topical anesthetic cream to the perineum and posterior wall of vagina prior to balloon catheter insertion as part of labor induction will reduce pain levels experienced by…
- Trial name
- TOLERANCE (NCT07288021)
- Testing
- Topical Analgesia with Lidocaine-Prilocaine cream
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Bnai Zion Medical Center
Pruritis, Hypotension Drug-Induced
Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.
The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women.
- Conditions
- Pruritis, Hypotension Drug-Induced, Urinary Retention, Fetal Bradycardia During Labor
- Trial name
- NCT07187427
- Testing
- Spinal analgesia, Epidural Analgesia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Cervical Ripening, Labor, Induced
Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess
The aim of this study is to compare two different preparation
- Trial name
- NCT00545194
- Testing
- Prostaglandin E2
- Where
- France
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Induced Labor
Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor
The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on…
- Trial name
- NCT07124130
- Testing
- 5% Dextrose (D5) in Normal Saline (NS), Lactate Ringer
- Where
- 2 sites in United States, Italy
- Volunteers
- 158 people
- Sponsor
- Eastern Virginia Medical School
Labour Analgesia, Epidural Anaesthesia, Duration of Labour
Impact of Timing of Neuraxial Analgesia on Obstetric, Anesthesiologic and Neonatal Outcomes in Induced Labour
The aim of this observational study is to assess the effect of early labour analgesia on obstetric and neonatal outcomes in induced labour in primiparous women with a full-term pregnancy whose labour was induced with a Cook…
- Conditions
- Labour Analgesia, Epidural Anaesthesia, Duration of Labour, Labor, Induced
- Trial name
- TAIL (NCT06886555)
- Testing
- Epidural analgesia for labour pain
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Labor, Induced, Patient Preference
Should I Have an Elective Induction?
The goal of the proposed study is to perform a pilot test of a patient-centered decision support tool to help pregnant people and providers work together in making informed, shared decisions regarding whether or not to opt for…
- Trial name
- SELECTION (NCT05838313)
- Testing
- Elective Induction of Labor Decision Support Tool
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie
Gestational Diabetes, Hypertension in Pregnancy
Sleep Improvement Therapy Affects Pregnancy Outcomes in Chinese Singletons and Twins by Improving Sleep Quality
During pregnancy, the physical and psychological changes of pregnant women, hyperemesis gravidarum, uterine compression, frequent urination, hip or pelvic pain, back pain, leg cramps, gastroesophageal reflux, changes in mental…
- Conditions
- Gestational Diabetes, Hypertension in Pregnancy, Preterm Labor, NICU Infants
- Trial name
- NCT06687044
- Testing
- Sleep restriction, Stimulation control, Cognitive therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jun Wei
Induced; Birth, Labor Onset and Length Abnormalities
Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction
This study aims to evaluate the efficacy and safety of combining papaverine with oxytocin for labor induction compared to oxytocin alone
- Trial name
- NCT06547437
- Testing
- Papaverine, normal saline
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya