Clinical trials: Induction Anesthesia
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Cerebral Oxygen Saturation
Changes of Cerebral Oxygenation During Anesthesia Induction
The aim of this study was to investigate the changes of cerebral oxygen saturation (rSO2) during anesthesia induction.
- Trial name
- NCT02687334
- Testing
- 100% Oxygen
- Where
- China
- Volunteers
- 33 people
- Sponsor
- China Medical University, China
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Anesthesia
MAPD: Modifiable Factors Affecting Propofol Dosing
The investigators aim to understand the effect of a caffeine intake, sleep habits, anxiety about surgery, alcohol intake and smoking status upon the dose of the anaesthetic drug, propofol, required for anaesthetic induction.
- Trial name
- NCT03453099
- Testing
- Preoperative Questionnaires, Postoperative Subjective Pain Scores
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Myoclonus
Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus
By observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring Narcotrend index, study the possible mechanism of influencing Etomidate induced myoclonus with Dexmedetomidine…
- Trial name
- NCT02518789
- Testing
- Low-dose Dexmedetomidine, High-dose dexmedetomidine, normal saline
- Volunteers
- 132 people
- Sponsor
- Tang-Du Hospital
Hypotension Drug-Induced
Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia
To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .
- Trial name
- NCT03478618
- Testing
- Lactated Ringer
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hypotension Drug-Induced
Different Preloads for Prevention of Hypotension in Patients Undergoing Elective CS Under Intrathecal Anesthesia
The aim of this study was to compare between crystalloid versus crystalloid and colloid combination preloads for prevention of hypotension following intrathecal anaesthesia in patients undergoing elective Caesarean section.
- Trial name
- NCT03465943
- Testing
- Ringer, Voluven
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Effect of Midazolam Premedication Before Induction on the Functional Recovery After General Anesthesia in the Patients Undergoing Breast Surgery Due to Breast Cancer
Normally, higher levels of preoperational stress or anxiety affect behavior and recovery after the operation. Moreover, patients undergoing mastectomy are usually young women, and this demographic is known to experience higher…
- Trial name
- NCT01945476
- Testing
- midazolam premedication
- Where
- South Korea
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Transcatheter Aortic Valve Replacement, Hemodynamic Stability
Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients
The purpose of this study is to evaluate whether the administration of 5 ml/kg of colloid solution prior to anesthesia induction, compared with 5 ml/kg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the…
- Conditions
- Transcatheter Aortic Valve Replacement, Hemodynamic Stability, Anesthesia Induction
- Trial name
- CHAIN-T (NCT07329660)
- Testing
- Hydroxyethyl starch 130/0.4, Lactate Ringer's Solution
- Volunteers
- 116 people
- Sponsor
- Air Force Military Medical University, China
Anesthesia, Block
Evaluating the Effectiveness of Bilateral ESPB in Addition to Standard Analgesia at Reducing Opioid Consumption
Study the benefits of a Erector Spinae nerve block for pain control and decrease narcotics usage after mammoplasty in an ambulatory setting
- Trial name
- NCT03954249
- Testing
- Erecto Spinae nerve block, Multimodal Analgesia
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Cataract, Mydriasis
Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification
Mydriatic eye drops are routinely used before phacoemulsification but they are not free of drawbacks. Several alternatives were tried to overcome their limitations.
- Conditions
- Cataract, Mydriasis, Adverse Drug Event
- Trial name
- NCT03638726
- Testing
- Atropine sulfate and epinephrine, Topical cyclopentolate and phenylephrine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Dar El Oyoun Hospital
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Tourniquet Hypertension
Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery
Knee pain is very common, and more people are having minor knee surgeries done through a small camera (arthroscopy), often as outpatients.
- Trial name
- torniquet (NCT06936410)
- Testing
- Lidocaine 2% Injectable Solution, Dexmedetomidine HCL Injection
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Cairo University
Inferior Vena Cava, Collapsibility Index
Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia
This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general…
- Conditions
- Inferior Vena Cava, Collapsibility Index, Caval Aorta Index, Induction
- Trial name
- NCT07399093
- Testing
- Inferior vena cava collapsibility index, Caval Aorta Index
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
General Anesthesia
Evaluation of CNAP During Anesthesia
The purpose of this study is to compare the non invasive measurement of arterial pressure (CNAP monitor) with the invasive measurement of arterial pressure (radial artery catheter) during induction and maintenance of general…
- Trial name
- CnapEval (NCT01032226)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Foch
Diuresis, Bladder Retention Volume
Effect of Preload on Bladder Retention Volume During Spinal Anesthesia
The purpose of this study is to assess the influence of different fluid infusions on the quantity of bladder retention after spinal anesthesia.
- Conditions
- Diuresis, Bladder Retention Volume, Hypotension
- Trial name
- NCT00550186
- Testing
- Ringers Lactate, HaemoHES 6%
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Rijnstate Hospital
Children Under General Anesthesia
Target-controlled Infusion of Propofol for Induction of Pediatric Anesthesia
The purpose of this study is to determine a effect-site concentration of propofol in children 3 to 11 years effective to make a induction of general anesthesia.
- Trial name
- NCT01411020
- Testing
- endotracheal intubation
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Rapid Sequence Induction of General Anesthesia, Sellick Maneuver
Sellick Interest in Rapid Sequence Induction
Lung aspiration can occur when a rapid sequence induction of anesthesia is performed (emergency and/or presence of at least one risk factor for regurgitation of stomach contents).
- Conditions
- Rapid Sequence Induction of General Anesthesia, Sellick Maneuver, Acid Aspiration Syndrome, Lung Aspiration
- Trial name
- IRIS (NCT02080754)
- Testing
- effective sellick maneuver
- Where
- France
- Volunteers
- 3,472 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Neurotoxicity
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals.
- Conditions
- Anesthesia, Neurotoxicity, Child Development
- Trial name
- TREX (NCT03089905)
- Testing
- Sevoflurane, Remifentanil, Dexmedetomidine
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 450 people
- Sponsor
- Murdoch Childrens Research Institute