Clinical trials: Induction Chemotherapy
Oncology, Cancer-related Cognitive Impairment
Effects of Cognitive Training on Chemotherapy-Induced Cognitive Impairment in Colon Cancer Patients Undergoing Treatment(Chemobrain) in Oncology Patients With Colon Cancer Undergoing Active Treatment
Introduction: With the increasing survival rate in colon cancer, as a result of technological and biomedical advancements, it is essential to thoroughly study the secondary symptoms related to the oncological disease process.
- Conditions
- Oncology, Cancer-related Cognitive Impairment, Cognitive Training, Everyday Cognition
- Trial name
- NCT06710639
- Testing
- Health Education Program, Cognitive Training Program
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Purpura, Thrombocytopaenic, Idiopathic
Study Of SB-497115 in Healthy Subjects and Subjects With Mild, Moderate or Severe Renal Impairment
The main purpose of this study is to compare how one 50 mg tablet of SB-497115 is broken down in the body by healthy subjects versus subjects with mild, moderate or severe kidney problems.
- Trial name
- NCT00442871
- Testing
- eltrombopag
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
PTSD, Depression
Participatory System Dynamics vs Usual Quality Improvement: Staff Use of Simulation as an Effective, Scalable and Affordable Way to Improve Timely Mental Health Care?
Evidence-based VA care is best for meeting Veterans' mental health needs, such as depression, PTSD and opioid use disorder, to prevent suicide or overdose. But some key evidence-based practices only reach 3-28% of patients.
- Conditions
- PTSD, Depression, Opioid Use Disorder
- Trial name
- NCT04208217
- Testing
- Modeling to Learn (MTL), Usual quality improvement (QI)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Leukaemia (Acute), Acute Lymphoblastic Leukemia
Hepatoprotective for Children and Adolescent With Acute Lymphoblastic Leukemia
This current study will implement a proposed whole program of monitoring and prevention acute hepatic injury during the time of induction chemotherapy in children and adolescent with ALL.
- Trial name
- NCT06918054
- Testing
- Dietary modification, Supplementation of omega 3 fatty acids
- Where
- 2 sites in Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
This randomized controlled phase III trial aims to evaluate the use of electroacupuncture in combination with olanzapine-containing standard quadruple antiemetic drugs for the treatment of nausea and vomiting induced by highly…
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06200168
- Testing
- Electroacupuncture, Standard antiemetic treatment
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jiuda Zhao
Nausea and Vomiting, Chemotherapy-Induced
The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects
This A Three-Part Drug-Drug Interaction Study To Evaluate Effects of Casopitant On Dolasetron, Granisetron or Rosiglitazone When Co-Administered in Healthy Adults
- Trial name
- NCT00511823
- Testing
- casopitant, dolasetron, granisetron
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chinese Acupuncture
Chinese Acupuncture for Chemobrain in Elderly Cancer Patients
Elderly cancer patients would suffer cognitive impairment due to chemotherapy, and a series of neurocognitive symptoms, known as "chemobrain".
- Trial name
- NCT05876988
- Testing
- Chinese acupuncture
- Where
- China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Nausea and Vomiting, Chemotherapy-Induced
A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers
GW679769 may affect liver enzymes that metabolize warfarin. This study is designed to test the extent of the GW679769 affect on Warfarin levels in humans.
- Trial name
- NCT00404274
- Testing
- Casopitant (GW679769) oral tablets, Warfarin oral tablets
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chemotherapy-Induced Neutropenia
Evaluation of the Food Effect on the Safety, Tolerability, PK of EC-18 After Oral Administration in Healthy Volunteers
A Randomized, Open-Label, Single -Dose, Crossover, Phase I Clinical Trial to Evaluate the Effect of Food on the Safety, Tolerability and Pharmacokinetics of EC-18 after Oral Administration in Healthy Volunteers
- Trial name
- NCT02700360
- Testing
- high-fat diet, EC-18
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Neoplasms, Child
VR to Improve CINV, Sleep and Pain Among Children With Cancer in HK
Chemotherapy-induced nausea and vomiting, sleep quality and pain are the common symptoms experienced by children with cancer. These symptoms significantly devastate the children's quality of life.
- Conditions
- Neoplasms, Child, Nausea, Vomiting
- Trial name
- NCT04853303
- Testing
- Hypnosis VR
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Chemotherapy-induced Peripheral Neuropathy
Physiologic Measure of VIPN
The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents.
- Trial name
- NCT04786977
- Testing
- No Intervention, Observational Study
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
NSCLC Stage IIIB, NSCLC Stage IIIC
Clinical Outcomes of Tislelizumab Combined With Chemotherapy as Induction Therapy in Stage III (cTNM-IIIB/IIIC) NSCLC
This is an observational study evaluating the clinical characteristics, treatment patterns, and clinical outcomes in Stage III (cTNM-IIIB/IIIC) Non-Small Cell Lung Cancer.Patients meeting inclusion and exclusion criteria were…
- Trial name
- NCT06829641
- Testing
- Tislelizumab Combined with Chemotherapy,
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Healthy Volunteers
TAK-071 Scopolamine-Induced Cognitive Impairment Study
The purpose of this study is to assess the effect of a single oral dose of TAK-071 on the attenuation of cognitive deficit induced by scopolamine as measured by Groton Maze Learning Test (GMLT) (total number of errors).
- Trial name
- NCT02918266
- Testing
- Scopolamine, TAK-071, Donepezil
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Takeda
Chemotherapy-induced Peripheral Neuropathy
The Role of TRP Channels in CIPN
Part I: Evaluating the increase in dermal blood flow upon topical application of cinnamaldehyde and capsaicin on the fingers in healthy, male volunteers.
- Trial name
- NCT04415892
- Testing
- Cinnamaldehyde and capsaicin
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chemotherapy-Induced Neutropenia
Study to Evaluate the Safety, Tolerability and PK of EC-18 After Oral Administration in Healthy Volunteers
This study is a Dose block-randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Escalation, Phase I clinical trial to assess the safety, tolerability and pharmacokinetics of single-dose and…
- Trial name
- NCT02532712
- Testing
- EC-18
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Chemotherapy-induced Peripheral Neuropathy
A Novel Limb Cryocompression System for Prevention of Chemotherapy Induced Peripheral Neuropathy
The study aims to investigate the safety and tolerability of limb cryocompression in preventing of Chemotherapy-induced Peripheral Neuropathy via a newly developed limb cryocompression device in healthy subjects and cancer…
- Trial name
- NCT05095051
- Testing
- Paxman Cryocompression System (PCCS)
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Chemotherapy-induced Neutropenia, Chemotherapy-induced Nausea and Vomiting
Community-Led Action Research in Oncology: Improving Symptom Management
This study will be conducted at La Liga Contra el Cancer in San Pedro Sula, Honduras. The overall objective of this project is to improve symptom management for patients undergoing chemotherapy in Honduras.
- Conditions
- Chemotherapy-induced Neutropenia, Chemotherapy-induced Nausea and Vomiting, Anxiety, Depression
- Trial name
- CLARO (NCT03208816)
- Testing
- symptom management program for chemotherapy patients
- Where
- 2 sites in United States, Honduras
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Concomitant Limb Cryocompression and Scalp Cooling to Reduce Paclitaxel-induced Neuropathy and Alopecia
Paclitaxel is a chemotherapy drug that is used to treat breast cancer, one of the most common cancers. It causes two side effects very often - hair-loss and numbness.
- Trial name
- NCT03248193
- Testing
- Concomitant limb cryocompression and scalp cooling
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Hodgkin Disease Lymphoma
Sperm Epigenome in Hodgkin Lymphoma
Cancer treatments can have long-term effects on fertility. In men, scientific studies suggest that the process of sperm formation (spermatogenesis) may be disrupted even years after recovery, with potential consequences not only…
- Trial name
- SPELH (NCT07449832)
- Testing
- Additional semen samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital