Clinical trials: Induction Chemotherapy
Chemotherapy Induced Cardiotoxicity
Cardiac Magnetic Resonance for Early Detection of Chemotherapy or Radiation Therapy Induced Cardiotoxicity in Breast Cancer (CareBest)
Chemotherapy or radiation therapy-induced cardiotoxicity are well-recognized side effects in patients with cancer. The clinical significance of cardiotoxicity is growing with increasing cancer survivor-ship.
- Trial name
- NCT03301389
- Testing
- Cardiac magnetic resonance imaging
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Alcohol Use Disorder (AUD), Pharmacist-Patient Relations
Alcohol Telemedicine Consultation in Primary Care (ATC)
This pragmatic, cluster-randomized trial in adult primary care clinics in a healthcare system with a diverse membership will examine the effectiveness of an innovative, multi-faceted intervention, the Addiction Telemedicine…
- Conditions
- Alcohol Use Disorder (AUD), Pharmacist-Patient Relations, Alcohol Problem
- Trial name
- ATC (NCT05252221)
- Testing
- ATC Intervention
- Where
- 2 sites in United States
- Volunteers
- 41,843 people
- Sponsor
- Kaiser Permanente
Arthritis, Arthritis, Rheumatoid
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
The purpose of this study is to examine whether an magnetic resonance imaging (MRI) -guided treatment strategy based on a predefined treatment algorithm can prevent progression of erosive joint damage, increase remission rate and…
- Conditions
- Arthritis, Arthritis, Rheumatoid, Joint Diseases, Musculoskeletal Diseases
- Trial name
- IMAGINE-RA (NCT01656278)
- Testing
- Magnetic resonance imaging (MRI), Conventional biochemical and clinical examinations
- Where
- 9 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen
Metastatic Colorectal Cancer
Impact of Early and Active Nutritional and Dietary Management grade3 or More Toxicities Induced by Chemotherapy and Targeted Therapies Administered to Patients as First Intention for Non Surgical Metastatic Colorectal Cancer
Description of active nutritional support: Early and active nutritional support is mainly concerned with maintaining protein and energy intake levels despite chemotherapy.
- Trial name
- CHIMIODIET (NCT01143285)
- Testing
- Early and active nutritional support.
- Where
- 8 sites in France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
CTIT-Chemotherapy Induced Thrombocytopenia, Breast Cancer
Hetrombopag for the Prevention of ADC-Induced Thrombocytopenia in Breast Cancer: An Exploratory, Dual-Cohort, Phase 2 Study
The title of this study is: A two-cohort, single-arm, exploratory Phase II clinical study on the primary/secondary prevention ADC drug of heltrombopag for thrombocytopenia caused by breast cancer.
- Trial name
- NCT07243418
- Testing
- herombopag olamine tablets
- Volunteers
- 72 people
- Sponsor
- Fujian Cancer Hospital
Chemotherapy-Induced Nausea and Vomiting (CINV)
Fosrolapitant Combined With Palonosetron to Prevent Trastuzumab Rezetecan Related CINV
This study is a prospective, single-arm, multicenter, exploratory clinical trial divided into a screening phase, a treatment phase, and a follow-up phase.
- Trial name
- NCT07726433
- Testing
- Fosrolapitant and Palonosetron Hydrochloride for Injection
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Ototoxic Hearing Loss
Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
One common side effect of cisplatin chemotherapy is ototoxicity. The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss.
- Trial name
- NCT05129748
- Testing
- Sodium Thiosulfate + Mannitol
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Sunnybrook Health Sciences Centre
to Evaluate the Effectiveness of Acupucnture in the Management of Chemotherapy-induced Nausea and Vomiting
The Different Effectiveness of Single Acupoint（PC6 or CV12) vs Matching Acupoints(PC6 and CV12) in Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to clarify whether the matching acupoints are more effective than a single point by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting .
- Trial name
- NCT02195908
- Testing
- single point Neiguan(PC6) plus antiemetic drug, single point Zhongwan(CV12) plus antiemetic drug, matching points Neiguan(PC6) and Zhongwan(CV12) plus antiemetic drug
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin University of Traditional Chinese Medicine
Abdominal Aortic Aneurysm,, Small Abdominal Aortic Aneurysm
Cyclosporine A in Patients With Small Diameter Abdominal Aortic Aneurysms
Aneurysms of the aorta are dilatations of the main artery in the body that distributes blood to organs. Aneurysms expose patients to aortic rupture.
- Trial name
- ACA4 (NCT02225756)
- Testing
- Cyclosporine A
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Drug-induced Nausea and Vomiting
Acupressure in Treating Nausea in Women Receiving Combination Chemotherapy for Breast Cancer
RATIONALE: Acupressure may help to reduce or prevent nausea in patients who are undergoing chemotherapy. It is not yet known whether acupressure plus standard care for nausea is more effective than standard care alone for nausea…
- Trial name
- NCT00046865
- Testing
- acupressure therapy, management of therapy complications, nausea and vomiting therapy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-induced Peripheral Neuropathy
A Study of Topical Pirenzepine or Placebo in Oncology Patients With Chemotherapy Induced Peripheral Neuropathy
This is a randomized, double-blind, placebo-controlled adaptive study of the safety, tolerability, and exploratory efficacy of once-daily topical WST-057 administered for up to 19 weeks (or up to 24 weeks for subjects who…
- Trial name
- NCT05488873
- Testing
- WST-057 Active
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- WinSanTor, Inc
Breast Cancer, Early-stage Breast Cancer
Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)
The purpose of this post-market, prospective study is to assess the ability of AMMA to prevent hair loss in women receiving chemotherapy (CT) for early-stage breast cancer.
- Conditions
- Breast Cancer, Early-stage Breast Cancer, Hair Loss, Alopecia
- Trial name
- NCT06215469
- Testing
- Amma Portable Scalp Cooling System (PSCS), Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Anemia, Neoplasms
Asses the Impact of Early Starting Erythropoetin in the Reduction of Transfusions Blood in Childrens
Anemia is a frequent complication among cancer patients, both as a result of the malignancy of the disease and the aggressiveness of the treatment.
- Conditions
- Anemia, Neoplasms, Chemotherapeutic-Induced Anemia
- Trial name
- NCT05704894
- Testing
- Erythropoietin
- Volunteers
- 320 people
- Sponsor
- Blau Farmaceutica S.A.
Nasopharyngeal Carcinoma, Children
Induction Chemotherapy in Young Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
1. To see the effect if a combination of induction chemotherapy followed by chemoradiotherapy works in treating children with advanced nasopharyngeal carcinoma(NPC).
- Trial name
- NCT03020329
- Testing
- Paclitaxel liposome, Cisplatin, 5-fu
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-sen University
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Breast Cancer
Effects of Cryotherapy on Taxane-Induced Neuropathy in Patients With Breast Cancer
Due to well-proven survival benefit, paclitaxel and other taxane-based chemotherapies are first-line agents for both the adjuvant and neoadjuvant treatment of early stage breast cancer.
- Trial name
- NCT05928429
- Testing
- Elasto-Gel™ mitts for hands: TM7008, and slippers for feet: SL3000; Southwest Technologies, Inc., North Kansas City, MO, USA
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Maria Lendorf
Chemotherapy-induced Neutropenia
Study of Recombinant Human Serum Albumin/Granulocyte Colony-Stimulating Factor Fusion Protein
The purpose of this study is to evaluate the dosages of recombinant human serum albumin/granulocyte colony-stimulating factor fusion protein by injection for preventing neutrophilic granulocytopenia among chemotherapy patients.
- Trial name
- NCT02465801
- Testing
- HSA-GCSF 1.2 mg, HSA-GCSF 1.5 mg, GCSF
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Tianjin SinoBiotech Ltd.
Head and Neck Cancer
S0216, Combination Chemotherapy and RT in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00054054
- Testing
- cisplatin, docetaxel, fluorouracil
- Where
- 95 sites in United States, Canada
- Sponsor
- SWOG Cancer Research Network
Recurrent Head and Neck Cancer, Carcinoma, Squamous Cell of Head and Neck
A Study to Evaluate the Safety and Efficacy of Amphinex Induced PCI of Bleomycin for Recurrent Head and Neck Cancer.
The purpose of this study is to evaluate the efficacy and safety of Amphinex induced PCI of bleomycin ('PC-A11') with superficial and/or interstitial laser light application in patients with recurrent SCCHN.
- Trial name
- NCT01606566
- Testing
- Amphinex induced PCI of bleomycin
- Where
- 10 sites in France, Germany and 4 more
- Volunteers
- 26 people
- Sponsor
- PCI Biotech AS
Pediatric Cancer, Thrombocytopenia
A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia
This study evaluates the use of tranexamic acid (TXA) in addition to standard therapy in children receiving chemotherapy or blood and/or marrow transplantation to decrease the risk of bleeding.
- Conditions
- Pediatric Cancer, Thrombocytopenia, Hemostatic Disorder, Coagulation Defect; Acquired
- Trial name
- NCT03806556
- Testing
- Tranexamic Acid, Normal saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Meghan McCormick
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