Clinical trials: Induction Chemotherapy
Locally Advanced Head and Neck Squamous Cell Carcinoma
Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
The purpose of the study is to evaluate the efficacy and safety of induction mTPF chemotherapy followed by concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck cancer
- Trial name
- NCT05527782
- Testing
- modified TPF, Quality of life assessment (QoL)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario Doctor Peset
CTIT-Chemotherapy Induced Thrombocytopenia
A Multicenter Randomized Controlled Study on the Treatment of Refractory CTIT With Romiplostim N01 Compared to Recombinant Human Thrombopoietin
A Multicenter Randomized Controlled Study on the Treatment of Refractory CTIT With Romiplostim N01 Compared to Recombinant Human Thrombopoietin
- Trial name
- NCT06440824
- Testing
- Romiplostim N01, Recombinant Human Thrombopoietin
- Volunteers
- 60 people
- Sponsor
- Shandong University
Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Schizophrenia and Related Disorders
Substance Misuse To Psychosis for Stimulants
In Hong Kong, less than 5% of stimulants abusers were reported to misuse these substances via injection. Also, it is well known that patients with co-morbid substance abuse/dependence and psychosis or schizophrenia-related…
- Conditions
- Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Schizophrenia and Related Disorders, Stimulant Dependence, Stimulant Abuse
- Trial name
- NCT03485417
- Testing
- Aripiprazole, Paliperidone, Treatment as Usual
- Where
- Hong Kong
- Volunteers
- 165 people
- Sponsor
- The University of Hong Kong
Nasopharyngeal Carcinoma
Nituzumab (Taixinsheng ®） A Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Clinical Study on the Efficacy and Safety of Combined Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinomatreatment of Locally Advanced Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a head and neck tumor. Studies have shown that more than 70% of patients are diagnosed with locally advanced nasopharyngeal carcinoma at the time of initial diagnosis.
- Trial name
- NCT05508347
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Chemotherapy-induced Anaemia
Erythropoietin and Iron Supplementation for Patients With Chemotherapy-induced Anaemia
A multicentre, randomized, open-label, parallel-group, active controlled non-inferiority study
- Trial name
- NCT02731378
- Testing
- Erythropoietins (EPO), Aggressive iron dextran supplementation, Sustained iron dextran supplementation
- Where
- 6 sites in China
- Volunteers
- 603 people
- Sponsor
- Shanghai East Hospital
Acute Myeloid Leukemia
Venetoclax + Azacitidine vs. Induction Chemotherapy in AML
This research is being done to assess the therapeutic activity of a promising combination (azacitidine and venetoclax) versus conventional cytotoxic chemotherapy in induction-eligible patients with acute myeloid leukemia.
- Trial name
- NCT04801797
- Testing
- Cytarabine, Idarubicin, Daunorubicin
- Where
- 9 sites in United States
- Volunteers
- 172 people
- Sponsor
- Massachusetts General Hospital
Acute Leukemia
Micafungin Prophylaxis During 1st Induction Chemotherapy for De Novo Acute Leukemia
The purpose of this study is to determine whether prophylaxis with micafungin is effective in the induction chemotherapy for newly diagnosed acute leukemia patients.
- Trial name
- NCT02440178
- Testing
- Micafungin
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital
Mantle-cell Lymphoma
Phase II of Efficacy and Toxicity of Maintenance Sub. Rituximab After Induction in Relapsed MCL and Non-eligible HSCT
1. Primary endpoint: Time to relapse/progression (TTP) after achieving a complete or partial response with the (R-GemOxD)-induction therapy 2. Secondary endpoints: 1.
- Trial name
- MAN2 (NCT02267915)
- Testing
- subcutaneous Rituximab
- Where
- 15 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Effect of Immersive Virtual Reality on Postural Control and Risk of Fall in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of functional disability in cancer survivors. Patients with CIPN typically present with numbness, tingling, burning pain, and loss of proprioception, particularly…
- Trial name
- NCT07854574
- Testing
- The intervention will consist of conventional physical therapy exercise, Immersive Virtual Reality
- Volunteers
- 40 people
- Sponsor
- Cairo University
Nursing Caries
Foot Bath Effects on Chemotherapy-Induced Fatigue in Pediatric Oncology
This study aims to evaluate the effects of foot baths on chemotherapy-induced fatigue in pediatric oncology patients. Current literature lacks studies assessing this intervention in the pediatric population.
- Trial name
- FBECIFPO (NCT06529484)
- Testing
- Warm Water Foot Bath Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Koç University
Ovarian Cancer, Uterine Cancer
Fosaprepitant Versus Aprepitant in the Prevention of Chemotherapy Induced Nausea and Vomiting
Nausea and vomiting are two of the more concerning adverse outcomes associated with chemotherapy in the treatment of gynecologic malignancies.
- Trial name
- NCT01432015
- Testing
- fosaprepitant, aprepitant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gynecologic Oncology Associates
Prostate Cancer, Cardiotoxicity
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer
This is an observational study for patients with prostate cancer that will be treated with Androgen Deprivation Therapy. The study will help the investigators learn more about how these medications affect the heart and how those…
- Conditions
- Prostate Cancer, Cardiotoxicity, Drug-Related Side Effects and Adverse Reactions, Cardiovascular Diseases
- Trial name
- PCT (NCT05096338)
- Testing
- Social Determinants of Health
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Neoplasms, Alopecia
Effect of Cryotherapy in the Prevention of Madarosis Produced by Chemotherapy in Breast Cancer Patients
Chemotherapy-induced alopecia (CIA) significantly compromises body image in breast cancer patients, particularly when involving eyebrow and eyelash loss (madarosis).
- Conditions
- Breast Neoplasms, Alopecia, Madarosis, Eyebrow Diseases
- Trial name
- NCT06955702
- Testing
- cryotherapy for chemotherapy-induced madarosis
- Where
- 2 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Multiple Myeloma
S0204 Thalidomide, Chemotherapy, and Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma
RATIONALE: Thalidomide may stop the growth of cancer cells by stopping blood flow to the cancer. Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00040937
- Testing
- filgrastim, sargramostim, cyclophosphamide
- Where
- 141 sites in United States
- Volunteers
- 147 people
- Sponsor
- SWOG Cancer Research Network
Neuropathic
Pulsed Electromagnetic Field Therapy to a Tailored Exercise Program for Patients Suffering From Chemotherapy-induced Neuropathy Related to Breast Cancer
This research studied the usefulness of a targeted intervention designed to manage chemotherapy-induced symptoms, particularly focusing on pain relief, balance deviations and functional improvements.
- Trial name
- PEMFTEPCHIN (NCT06947577)
- Testing
- pulsed electromagnetic field (PEMF) therapy and a tailored exercise program (TEP), Tailored Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Acute Myeloid Leukemia, Induction Chemotherapy
Study of DAC Combined With HAAG Regimen in Newly Diagnosed Younger AML Patients
The purpose of this study is to evaluate the safety and efficacy of DAC combined with HAAG regimen in the induction treatment of newly diagnosed AML patients younger than 60 years.
- Trial name
- NCT04087967
- Testing
- Decitabine plus HAAG regimen, Idarubicine plus Cytarabine regimen
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Nucleophosmin 1-mutated Acute Myeloid Leukemia
Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML
The primary objective of this study is to evaluate the efficacy of entospletinib (ENTO) compared to placebo when added to chemotherapy in previously untreated nucleophosmin-1 mutated (NPM1-m) acute myeloid leukemia (AML), as…
- Trial name
- NCT05020665
- Testing
- Entospletinib, Cytarabine, Anthracycline
- Where
- 83 sites in United States, Brazil and 10 more
- Volunteers
- 15 people
- Sponsor
- Kronos Bio
the Focus of the Study is Macrophage-induced Chemoresistance in Pancreatic Carcinoma Cells During Chemotherapy.
Macrophages Effect on Chemoresistance
Macrophages are derived from monocytes recruited to the tumor site and stimulated by specific chemokines secreted by tumor cells.
- Trial name
- NCT01921699
- Testing
- taking blood samples from healthy people
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Doxorubicin Adverse Reaction, Cardiomyopathies, Secondary
The Role of suPAR Biomarker in Blood Samples of Breast Cancer Patients During and Post Doxorubicin Chemotherapy: Causative vs. Predictor
This study looks to find a causative or predictive aspect of the suPAR biomarker for heart failure in breast cancer patients receiving Doxorubicin drug chemo regimen.
- Conditions
- Doxorubicin Adverse Reaction, Cardiomyopathies, Secondary, Breast Cancer
- Trial name
- NCT03505164
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Chemotherapy Induced Anemia
A Study of AND017 in Cancer Related Anemic Patients Receiving Chemotherapy
The purpose of this study is to determine the safety and efficacy of AND017 after 6 weeks of treatment in patients with cancer-related anemia who are receiving chemotherapy.
- Trial name
- NCT06075030
- Testing
- AND017
- Volunteers
- 36 people
- Sponsor
- Kind Pharmaceuticals LLC
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