Clinical trials: Induction Chemotherapy
Chemotherapy-Induced Nausea and Vomiting
Phase 2 Study of Efficacy, Tolerability, and Safety of Intranasal Granisetron for Chemo-Induced Nausea and Vomiting
Brief Summary: A randomized, single administration, double-blind, parallel- group Phase 2 dose finding study to assess the efficacy, tolerability, and safety of TRG in patients with chemotherapy-induced nausea and vomiting (CINV)…
- Trial name
- NCT00787566
- Testing
- Intranasal granisetron
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Shin Nippon Biomedical Laboratories, Ltd.
Pancreatic Cancer
Combination Chemotherapy Followed by Chemotherapy and Radiation Therapy and/or Surgery in Treating Patients Who Have Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug with radiation therapy and/or surgery may kill more tumor cells.
- Trial name
- NCT00003332
- Testing
- cisplatin, gemcitabine hydrochloride, surgical procedure
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- NYU Langone Health
Alcoholism
COMBINE (Acamprosate/Naltrexone)
Combine is a multicenter, randomized clinical trial that will evaluate combinations of three interventions for treating alcohol dependence.
- Trial name
- NCT00006206
- Testing
- naltrexone (Revia), acamprosate (Campral)
- Where
- 12 sites in United States
- Volunteers
- 1,375 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Adenocarcinoma
Chemotherapy Combined Autologous Cytokine-induced Killer Cells in Naive Stage IV EGFR-wild Type Lung Adenocarcinoma
This is a prospective, randomized, open, multicenter phase Ⅱ study to evaluate the efficacy of cytokine-induced killer cells combined chemotherapy in stage Ⅳ naive EGFR wild-type lung adenocarcinoma.
- Trial name
- NCT02621333
- Testing
- CIK, chemotherapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Henan Cancer Hospital
Nausea and Vomiting Chemotherapy-Induced, Meditation Training
Meditation for Chemotherapy-Induced Nausea and Vomiting in Women With Breast Cancer
This randomized clinical trial aimed to evaluate the effectiveness of Twin Hearts Meditation in reducing chemotherapy-induced nausea and vomiting among women with breast cancer undergoing chemotherapy.
- Trial name
- Breast Cancer (NCT07470619)
- Testing
- Twin Heart Meditation
- Where
- Cyprus
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Alcohol Dependence
Efficacy and Tolerability of Baclofen for Alcohol Dependence
This is a study of the efficacy and safety of baclofen for alcohol dependence. 80 outpatient subjects with DSM-IV alcohol dependence will be randomized to 10 mg three times a day (tid) baclofen or tid placebo.
- Trial name
- NCT00877734
- Testing
- baclofen, BRENDA counseling
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
Epithelial Ovarian Cancer, Fallopian Tube Carcinoma
Hyperthermic Intraoperative Intraperitoneal Chemotherapy of Recurrent Ovarian Cancer - A Feasibility Study
Most studies performing hyperthermic intraoperative intraperitoneal chemotherapy dose the cytotoxic drugs according to the body surface (like 50 mg/m² cisplatin) in analogy to systemic, intravenous chemotherapy (usually using the…
- Trial name
- NCT00968799
- Testing
- Hyperthermic intraoperative intraperitoneal chemotherapy, Cytoreduction, Cisplatin
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Cantonal Hospital of St. Gallen
Breast Cancer, Chemotherapy Induced Systolic Dysfunction
Early Detection of CMP in Patients With Breast Cancer Using Cardiac Magnetic Resonance
Breast cancer is the most common cancers among women worldwide.Although chemotherapy and surgery have greatly improved the survival rate, most types of chemotherapy have been reported to have varying degrees of cardiotoxicity.
- Trial name
- NCT04510532
- Testing
- CMR examination
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Multiple Myeloma, Plasma Cell Neoplasm
Biomarkers Related to Thrombosis in Patients With Newly Diagnosed Multiple Myeloma Receiving Chemotherapy
RATIONALE: Studying samples of blood in the laboratory from patients receiving chemotherapy may help doctors learn more about the effects of chemotherapy on cells.
- Conditions
- Multiple Myeloma, Plasma Cell Neoplasm, Thromboembolism
- Trial name
- NCT01132833
- Testing
- enzyme-linked immunosorbent assay, laboratory biomarker analysis, medical chart review
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Esophageal Cancer, Gastric Cancer
Cisplatin and Irinotecan Chemotherapy, Followed by ZD 1839 (Iressa) in Patients With Esophageal or Gastric Carcinomas
This study is for patients with esophageal, esophagogastric, or gastric cancer that has spread to other parts of the body. The purpose of this study is to test the safety and effectiveness of a new experimental drug called ZD…
- Trial name
- NCT00215995
- Testing
- Cisplatin, Irinotecan, ZD 1839
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Acute Pain, Breast Carcinoma
Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel
This randomized pilot trial studies how well minocycline hydrochloride works in reducing chemotherapy-induced peripheral neuropathy and acute pain in patients with breast cancer undergoing treatment with paclitaxel.
- Conditions
- Acute Pain, Breast Carcinoma, Peripheral Neuropathy
- Trial name
- NCT02297412
- Testing
- Minocycline Hydrochloride, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 12 sites in United States
- Volunteers
- 47 people
- Sponsor
- Academic and Community Cancer Research United
Malignant Solid Neoplasm
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression.
- Trial name
- ICE COMPRESS (NCT05642611)
- Testing
- Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy
- Where
- 36 sites in United States
- Volunteers
- 777 people
- Sponsor
- SWOG Cancer Research Network
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer
The goal of this study is to obtain preliminary evidence of the effect of 8 acupuncture treatments over 10 weeks in breast and GI cancer patients who are currently receiving or recently completed active neurotoxic chemotherapy…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03505671
- Testing
- Acupuncture Therapy, Best Practice, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences
Thrombocytopaenia
Safety and Efficacy Study for Solid Tumor Patients Treated With Eltrombopag
The present study is a randomized, blinded, placebo-controlled, two-Phase, sequential cohort, dose finding study to assess the safety and efficacy of eltrombopag in patients with solid tumors receiving gemcitabine monotherapy or…
- Trial name
- NCT01147809
- Testing
- Eltrombopag olamine
- Where
- 86 sites in United States, Belgium and 11 more
- Volunteers
- 130 people
- Sponsor
- GlaxoSmithKline
Cancer Survivors, Chemotherapy-related Cognitive Impairment
Neuroplasticity-Based Cognitive Remediation for Chemotherapy-Related Cognitive Impairment
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to treat chemotherapy-related cognitive impairment (CRCI).
- Trial name
- NCT04230863
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Nasopharyngeal Carcinoma
The Role of Induction Gemcitabine and Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma in the Era of IMRT
The purpose of this study is to verify that induction gemcitabine and cisplatin plus intensity-modulated radiotherapy (IMRT) is non-inferior to concurrent weekly cisplatin plus IMRT for patients with locoregionally advanced…
- Trial name
- NCT02460887
- Testing
- Gemcitabine, cisplatin, Intensity-modulated Radiotherapy
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Sun Yat-sen University
Acute Lymphocytic Leukemia
Clinical Study of Recombinant Anti-CD19m-CD3 Antibody Injection (A-319)
This is an exploratory study with an open-label, single-arm, single-center design. It plans to enroll subjects with refractory/relapsed acute B-cell lymphoblastic leukemia (B-ALL), or treatment-naive or previously treated B-ALL…
- Trial name
- A-319 (NCT07371533)
- Testing
- Treatment with A319
- Volunteers
- 18 people
- Sponsor
- Shanxi Bethune Hospital
Acute Myeloid Leukemia, Adult
Investigation of the Gut Microbiota in Acute Myeloid Leukemia Receiving Two Different Induction Therapies
In this observational single-center cohort study, metagenomic Next-Generation Sequencing (mNGS) will be used to investigate the features and changes of gut microbiota in acute myeloid leukemia (AML) patients during the treatment…
- Conditions
- Acute Myeloid Leukemia, Adult, Gut Microbiota, Infections
- Trial name
- NCT05123352
- Testing
- collection of biological samples and clinical data
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Mucositis
Phase 2a Study to Evaluate Suppression of 5-Fluorouracil -Induced Mucositis by TK112690
Patients expected to receive a 500 mg/m2 of Leucovorin by iv \& 500 mg/m2 of Fluorouracil (5FU) by iv bolus for their Colorectal Cancer.
- Trial name
- NCT05669521
- Testing
- TK-112690
- Where
- 5 sites in India
- Volunteers
- 24 people
- Sponsor
- Tosk, Inc.
Ganglioneuroblastoma, Stage 1 Neuroblastoma
Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma
This pilot clinical trial studies busulfan, melphalan, and stem cell transplant after chemotherapy in treating patients with newly diagnosed neuroblastoma that is likely to come back or spread.
- Conditions
- Ganglioneuroblastoma, Stage 1 Neuroblastoma, Stage 2 Neuroblastoma, Stage 2A Neuroblastoma
- Trial name
- NCT01798004
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Busulfan, Cisplatin
- Where
- 123 sites in United States, Australia and 2 more
- Volunteers
- 150 people
- Sponsor
- Children's Oncology Group