Clinical trials: Induction Chemotherapy
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma
This phase II trial studies how well oxaliplatin, leucovorin calcium, and fluorouracil followed by surgery and response based concurrent chemotherapy and radiation therapy works in treating patients with cancer of the esophagus…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Gastric Cardia, Stage IIIA Esophageal Cancer
- Trial name
- NCT02037048
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Case Comprehensive Cancer Center
Fertility Preservation, Alkylating Agents
Efficiency of Gonadotropin-releasing Hormone (GnRH) Agonist in Preventing Chemotherapy Induced Ovarian Failure
Chemotherapy drugs like alkylating agents are frequently used in various combined regimens to treat neoplastic and benign diseases.
- Conditions
- Fertility Preservation, Alkylating Agents, Lymphoma
- Trial name
- Erasme-POF (NCT01160315)
- Testing
- Triptorelin, Norethisterone acetate
- Where
- 15 sites in Belgium, France and 1 more
- Volunteers
- 118 people
- Sponsor
- Erasme University Hospital
Nasopharyngeal Carcinoma
TPF+CCRT vs.CCRT+PF in High Risk Nasopharyngeal Carcinoma
To see the effect of induction chemotherapy（TPF） followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy (PF) in treating patients with high risk nasopharyngeal carcinoma…
- Trial name
- NCT03306121
- Testing
- TPF+CCRT, CCRT+ PF
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Sun Yat-sen University
Pediatric Cancer, Nausea With Vomiting Chemotherapy-Induced
The Effect of Acupressure Chemotherapy-related Nausea Vomiting in Children
This study is carried out to evaluate and compare the efficiency of acupressure practice applied with pressure or sea-band and their placebo on managing the acute nausea-vomiting symptoms developing due to chemotherapy in…
- Trial name
- NCT04651608
- Testing
- manuel acupressure, sea-band acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Akdeniz University
Pain, Peripheral Neuropathy
Effects of Neurofeedback on Neural Function, Neuromodulation, and Chemotherapy-Induced Neuropathic Pain
The goal of this study is to learn if using a non-invasive therapy called "neurofeedback training" can help teach patients ways to modify their own brain waves to decrease the perception of pain and improve quality of life.
- Trial name
- NCT01278225
- Testing
- EEG biofeedback (BF) Group, Wait-List Control (WLC) Group, Follow UP Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Neoplasm, Chemotherapeutic Toxicity
Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum
Observational, clinical study. Intention to include 40 patients (20 patients treated with trabectedin and 20 with cisplatin hypersensitivity) The investigators investigate the role of trabectedin in combination with PLD and…
- Conditions
- Ovarian Neoplasm, Chemotherapeutic Toxicity, Chemotherapy Effect, Chemotherapy-induced Neutropenia
- Trial name
- TvsCH (NCT05512676)
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Acute Myelogenous Leukemia, Chemotherapy-induced Nausea and Vomiting
Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting
The goal of this clinical research study is to compare the effectiveness of 3 drug schedules in preventing chemotherapy-related nausea and/or vomiting in patients with acute myelogenous leukemia (AML) or high-risk myelodysplastic…
- Trial name
- NCT01031498
- Testing
- Ondansetron, Palonosetron
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
An Observational Study of Continued Bevacizumab Plus Chemotherapy Until First Progression in Participants With Metastatic Colorectal Cancer (CRC)
This prospective, multicenter, observational study will investigate the effectiveness and safety of bevacizumab in routine clinical practice in participants with metastatic CRC.
- Trial name
- AVACONT (NCT02305615)
- Testing
- Bevacizumab, Chemotherapy
- Where
- 22 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Anemia, Chemotherapy
Hematologic Response of Epoetin Alfa (PROCRIT) Versus Darbepoetin Alfa (ARANESP) in Chemotherapy Induced Anemia
The purpose of this study is to compare hemoglobin (Hgb) response rates between epoetin alfa (PROCRIT; 40,000 Units (U) SC weekly) and darbepoetin alfa (ARANESP; 200 mcg every other week) in anemic cancer patients receiving…
- Trial name
- NCT00315484
- Testing
- Epoetin alfa and Darbepoetin alfa
- Volunteers
- 358 people
- Sponsor
- Ortho Biotech Products, L.P.
Tobacco Dependence
Smoking Cessation Intervention: Effectiveness in Primary Care
The information gathered in this study may help to develop more effective ways to help people quit smoking and stay quit in the future.
- Trial name
- NCT00296647
- Testing
- nicotine patch, nicotine lozenge, bupropion
- Where
- United States
- Volunteers
- 1,346 people
- Sponsor
- University of Wisconsin, Madison
Small Cell Lung Cancer
Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Stage Small Cell Lung Cancer
To evaluate the efficacy and safety of maintenance therapy with Adebrelimab plus Apatinib for extensive stage small cell lung cancer after first-line induction of Adebrelimab plus chemotherapy.
- Trial name
- NCT06480864
- Testing
- Adebrelimab Injection, Apatinib Mesylate Tablets, Carboplatin
- Where
- 2 sites in China
- Volunteers
- 38 people
- Sponsor
- Yunpeng Liu
Cancer, Chemotherapy-induced Peripheral Neuropathy
Combined Qigong and Acupressure for Improving Chemotherapy-induced Peripheral Neuropathy
The objective of the study is to investigate the effects of a 16-week combined qigong and acupressure intervention on reducing self-reported chemotherapy-induced peripheral neuropathy (CIPN) severity, objective measures of CIPN…
- Trial name
- NCT05764447
- Testing
- Combined qigong Baduanjin and self-administered acupressure, Wait-list Control
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- The University of Hong Kong
Chemotherapy Induced Thrombocytopenia
A Clinical Study on the Efficacy and Safety of Hetrombopag in the Treatment of Thrombocytopenia Induced by Gynecological Tumor Therapy
The study consists of five sequential periods: Screening (≤ 4 weeks) Correction phase Maintenance phase (first treatment cycle, Cycle 1) Observation phase (second treatment cycle, Cycle 2) Follow-up Eligible subjects are…
- Trial name
- NCT07408648
- Testing
- hetrombopag 7.5 mg orally once daily
- Volunteers
- 244 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nausea, Vomiting
Ginger Control of Chemotherapy Induced Nausea and Vomiting
This is a trial to determine the safety and efficacy of ginger in reducing the prevalence and severity of chemotherapy induced nausea and vomiting.
- Conditions
- Nausea, Vomiting, Chemotherapy
- Trial name
- NCT00065221
- Testing
- Ginger
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 180 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pancreatic Cancer
Low-dose Radiotherapy Plus Chemotherapy With Gem-based Doublets and Stereotactic Radiotherapy for Advanced Pancreatic Cancer
Aim of this study is to evaluate if low-dose radiotherapy (LDR) can intensify local effect of a chemotherapy regimen with Gem-based doublets administered sequentially with stereotactic body radiotherapy (SBRT) and to assess the…
- Trial name
- ORCHESTRATE (NCT02416609)
- Testing
- LDR, Gem-based doublets, SBRT
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Chemotherapy-induced Nausea and Vomiting
Acupuncture for Chemical Therapy Induced Nausea and Vomiting: a Cross-over Trail
This is a randomized, controlled cross-over trial. The hypothesis of this study is that the differences in manual acupuncture manipulation can impact clinical effect though the acupuncturists follow the same needling regimen.
- Trial name
- ACTIN (NCT02127255)
- Testing
- Manual acupuncture implemented by acupuncturist 1, Manual acupuncture implemented by acupuncturist 2
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Beijing University of Chinese Medicine
Vomiting, Nausea
A Study of Ramosetron Plus DX, Dexamethasone, Compared to Granisetron Plus DX for the Prevention of Vomiting and Nausea
The purpose of this study is to compare the efficacy and safety of ramosetron plus dexamethasone injection with granisetron plus dexamethasone injection for the prevention of chemotherapy-induced vomiting and nausea.
- Trial name
- NCT00272285
- Testing
- Ramosetron, Granisetron
- Where
- 2 sites in Taiwan
- Volunteers
- 287 people
- Sponsor
- Astellas Pharma Inc
NSCLC, Stage III
Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus Durvalumab and Consolidation Immunotherapy in Patients With Resectable Stage III NSCLC.
To compare a complex induction multimodality protocol (ESPATUE) + concurrent immunotherapy with PD-L1 antibody Durvalumab given every three weeks to the same induction multimodality protocol without Durvalumab immunotherapy…
- Trial name
- ESPADURVA (NCT04202809)
- Testing
- Durvalumab
- Where
- 7 sites in Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital, Essen
Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy
Impact of an Orthotic Intervention in Children With Peripheral Neuropathy
This research study will investigate the effect of two orthotic (brace) devices for the ankle and foot on walking and ankle flexibility in children with cancer not involving the brain or spinal cord.
- Conditions
- Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy, Acute Lymphocytic Leukemia, Pediatric, Rhabdomyosarcoma
- Trial name
- IOPN (NCT03655587)
- Testing
- Solid ankle foot orthotic, Resting night splint
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Breast Cancer, Chemotherapy Induced Peripheral Neuropathy (CIPN)
Simple Surgical Glove Compression to Prevent Chemotherapy-Induced Peripheral Neuropathy
To evaluate the preventive efficacy of a simple surgical glove compression technique in reducing the incidence and severity of Chemotherapy Induced Peripheral Neuropathy among patients receiving chemotherapy.
- Conditions
- Breast Cancer, Chemotherapy Induced Peripheral Neuropathy (CIPN), Neoadjuvant Therapy
- Trial name
- NCT07169864
- Testing
- Simple Surgical Glove Compression Technique
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Jinsong Lu
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