Clinical trials: Induction Therapy
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Infertility, Female
Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles
The aim of this study will be to compare between 4 different induction protocols in women who: 1. Failed to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patient can tolerate this dose) for…
- Trial name
- NCT05362799
- Testing
- Letrozol (Femara, Novartis), Letrozol (Femara, Novartis) combined with Metformin (Cidophage 500 mg, Cid Pharmaceuticals, Egypt), highly purified lyophilized Uroffollitropin (Fostimon, IBSA Institut Biochimique SA, Lugano, Switzerland)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Nightmare
Treating Nightmares Among Domiciliary Patients
The purpose of the study is to assess the efficacy of a 2-session intervention to reduce nightmares among Veterans admitted VA mental health residential rehabilitation treatment programs.
- Trial name
- NCT04341987
- Testing
- brief Imagery Rehearsal Therapy, Treatment As Usual
- Volunteers
- healthy volunteers welcome
- Sponsor
- Canandaigua VA Medical Center
Oxidative Stress Induction, Endothelial Dysfunction
Role of Traditional Cigarettes, Electronic and IQOS Cigarettes on Oxidative Stress.
Electronic cigarettes (E-cigarettes) and new heat-not-burn tobacco products such as IQOS®, an electronic device that heats a cigarette-like stick without combustion, are a modern and technological surrogate of traditional tobacco…
- Conditions
- Oxidative Stress Induction, Endothelial Dysfunction, Platelet Activation
- Trial name
- NCT03301129
- Testing
- Smoke
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Cystic Fibrosis
Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis
The study is defined in 3 stages of in vitro assays : Phase 1 : Secretion of NETs in response to lung disease and their secretion of factors.
- Trial name
- MucoNETs (NCT02564393)
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Pregnancy, Prolonged, Induced; Birth
Membrane Sweeping to Prevent Post-term Pregnancy: The MILO Study
Multicentre, pragmatic, parallel group, pilot randomised controlled trial with an embedded factorial design.
- Conditions
- Pregnancy, Prolonged, Induced; Birth, Pregnancy Related
- Trial name
- MILO (NCT04307199)
- Testing
- Amniotic membrane sweep
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Leukaemia (Acute), Acute Lymphoblastic Leukemia
Hepatoprotective for Children and Adolescent With Acute Lymphoblastic Leukemia
This current study will implement a proposed whole program of monitoring and prevention acute hepatic injury during the time of induction chemotherapy in children and adolescent with ALL.
- Trial name
- NCT06918054
- Testing
- Dietary modification, Supplementation of omega 3 fatty acids
- Where
- 2 sites in Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Parkinson Disease
Study to Evaluate the Effects of Cytochrome P450 (CYP) 3A4 Inducer Carbamazepine on Tavapadon Pharmacokinetics in Healthy Adult Participants
The primary purpose of this study is to evaluate the effect of carbamazepine, a strong CYP3A4 inducer, on the steady-state pharmacokinetics (PK) of tavapadon in healthy adult participants.
- Trial name
- NCT05581823
- Testing
- Tavapadon, Carbamazepine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Delivery Delayed
Nipple Stimulation for Labor Induction
This study will examine the use of nipple stimulation for cervical ripening in women who present to the labor and delivery ward after their water has broken but have a contraindication to prostaglandins.
- Trial name
- NCT03025503
- Testing
- nipple stimulation
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Sadness, Happiness
The Effect of Mood Induction in Body Image Through Virtual Reality
The effect of emotional induction of sadness (vs. joy) on the mental representation of the body image through the virtual reality
- Trial name
- EMOTION (NCT04617886)
- Testing
- Sadness induction, Happiness induction
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Mapping Approaches to Prepare for Implementation Transfer, Treatment Readiness and Induction Program
Mapping Approaches to Prepare for Implementation Transfer (MAP-IT)
Despite demonstrated effectiveness, evidence based practices are not widely incorporated into existing residential and outpatient treatments.
- Trial name
- MAP-IT (NCT04016831)
- Testing
- Mapping Enhanced Counseling (MEC), Mapping Approaches to Prepare for Implementation Transfer (MAP-IT)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Esophageal Squamous Cell Carcinoma, Neoadjuvant Therapies
Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: a Single Center, Prospective, Open, One Arm Exploratory Clinical Study
To purpose of this study is to access the safety and efficacy of neoadjuvant Immunotherapy (PD-1 / PD-L1) combined with chemotherapy for locally advanced thoracic esophageal squamous cellcarcinoma.
- Trial name
- NICCE (NCT05028231)
- Testing
- Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Excessive Somnolence
VSF-173 Study in Healthy Adult Volunteers for Treatment of Induced Excessive Sleepiness
The purpose of this study is to determine the safety and efficacy of VSF-173 compared to placebo in treatment of induced excessive sleepiness.
- Trial name
- NCT00467441
- Testing
- VSF-173
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Induction of Labour With Misoprostol
Comparison of Oral Versus Vaginal Misoprostol for Labour Induction at Term
A randomised control trial to compare oral and vaginal misoprostol for induction of labour in term patients.The objective is to determine whether use of standardised vaginal misoprostol regimen will result in decreased cesaerean…
- Trial name
- NCT05957666
- Testing
- Misoprostol Oral Tablet, vaginal misoprostol
- Where
- Pakistan
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Wrist Injuries
Effects of Low Level Laser Therapy On Exercise Induced Muscle Damage in Wrist Flexors Of Untrained Young Adults
The main aim of the current study is to investigate the effects of Low-level Laser Therapy on exercise-induced muscle damage of wrist flexors in untrained young adults.
- Trial name
- NCT04842669
- Testing
- low level laser therapy, Conservative treatment
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Gender Dysphoria, Hormone Therapy Induced Morphologic Change
Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content
Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body.
- Trial name
- NCT06291675
- Testing
- gender-affirming hormone therapy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Muscle Mass and Strength, Obesity & Overweight
Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment
This study aims to investigate the effect that a structured, progressive resistance exercise program may have on maintaining the muscle mass and physical function of overweight/ obese females whilst they experience a tirzepatide…
- Conditions
- Muscle Mass and Strength, Obesity & Overweight, Physical Function
- Trial name
- FLEX (NCT07457437)
- Testing
- Progressive Resistance Exercise Training Program, Habitual physical activity guidelines
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Exeter
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