Clinical trials: Induction of Anesthesia
General Anesthesia Induction for Elective Surgery
Carotid Artery Corrected Flow Time as a Predictor of Hypotension After Induction of General Anesthesia in Elderly Patients
The number of elderly patients undergoing elective surgery has been growing in recent years. Elderly patients often have a variety of underlying diseases, including hypertension, coronary heart disease, diabetes…
- Trial name
- NCT05628051
- Testing
- ultrasonographic measurement of carotid artery corrected flow time (FTc)
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Fujian Medical University Union Hospital
Hypotension, Anesthesia
Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study
In this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension.
- Conditions
- Hypotension, Anesthesia, Hypotension on Induction
- Trial name
- NCT05842759
- Testing
- Monitoring, Norepinephrine preparation, Propofol administration
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Induction of General Anesthesia
Propofol Versus Sevoflurane for Induction of GA in Infants
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
- Trial name
- NCT05105022
- Testing
- Propofol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Pain, During Injection of Propofol for Induction of Anesthesia
Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia
This research will be carried out in order to determine the optimal lidocaine dose in propofol lidocaine mixture to prevent pain on propofol injection during induction of general anesthesia using a modified Dixon's up-and-down…
- Trial name
- NCT05898061
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Anesthesia, Hypotension on Induction
Intraoperative Hypotension in High-risk Patients Undergoing Surgery
The primary objective of this observational study is to investigate the risk factors for intraoperative hypotension and identify the underlying pathomechanisms leading to it, both during the period after general anesthesia…
- Conditions
- Anesthesia, Hypotension on Induction, Perioperative Injury, Perioperative Hypotension
- Trial name
- IRIoHYP (NCT05884918)
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Mazovia Regional Hospital in Siedlce
Lung Cancer, Anesthesia Induction
95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment
General anesthesia with double-lumen endobronchial tubes intubation is the main anesthesia method in thoracic surgery.However, double-lumen endobronchial tubes intubation can produce greater stimulation and cause more…
- Trial name
- NCT05631028
- Testing
- Dexmedetomidine, Remimazolam tosilate
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Shiyou Wei
Anesthesia, Hypoxia
Preoxygenation With High-flow Nasal Oxygen in Adult Trauma Patients During Rapid Sequence Induction Anaesthesia
Previous studies investigating apnoea oxygenation has shown that delivering oxygen via a high flow can maintain adequate oxygen saturation levels in a patient for over 30 minutes.
- Conditions
- Anesthesia, Hypoxia, Trauma, Rapid Sequence Induction
- Trial name
- PRIOR-Trauma (NCT04926337)
- Testing
- Tight Fitting Facemask, High Flow Nasal Oxygen (HFNO)
- Where
- Sweden
- Volunteers
- 104 people
- Sponsor
- Karolinska University Hospital
Anesthesia Induction Ventilation
Safety and Efficacy of the Tao Facemask for Positive Pressure Ventilation in the Patients With Significantly Elevated BMIs
The Tao Mask is a new novel facemask for positive pressure ventilation which has recently been demonstrated (MUSC study Pro00047645) to have superior performance to our conventional (standard) positive pressure mask in a random…
- Trial name
- NCT03473366
- Testing
- Tao Mask, Standard Mask
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-induction Hypotension, Post Anesthesia Recovery
Intraoperative Hypotension and Post-anesthesia Care Unit Recovery
The underlying causative mechanism that leads to intraoperative hypotension (IOH) may vary depending on the stage of anesthesia and surgery, which determines different IOH types.
- Conditions
- Post-induction Hypotension, Post Anesthesia Recovery, Hypotension, Intraoperative Hypotension
- Trial name
- NCT05671783
- Testing
- Hemodynamic observation of the patients.
- Where
- Turkey (Türkiye)
- Volunteers
- 4,776 people
- Sponsor
- Acibadem University
General Anesthesia, Hypotension on Induction
Ultrasonographic Predictors of Hypotension After Induction
The purpose of the study is to evaluate the predictive value of the inferior vena cava collapsibility index and caval aorta index for detecting hypotension after induction of general anesthesia.
- Trial name
- NCT05239234
- Testing
- Inferior vena cava-Aorta diameter index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Antalya Training and Research Hospital
Induction of General Anesthesia
A Comparison Between Ketamine-lidocaine Versus Ketamine-fentanyl for Induction on the Hemodynamic Effects in Patients With Coronary Artery Disease
Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) presenting for coronary artery bypass grafting (CABG) represent a high-risk group among the cardiac surgical population.
- Trial name
- NCT05502211
- Testing
- Fentanyl, Lidocaine IV
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Kasr El Aini Hospital
Induction of Anesthesia
Explore the Advantages of Remimazolam Used on Gastroscopy
There are many different types of intravenous anesthetics used in gastroscopy, but each type of drug has its advantages and disadvantages,remimazolam is a novel ultra-short-acting benzodiazepine with rapid onset and recovery, low…
- Trial name
- NCT05429086
- Testing
- Remimazolam combined propofol, Remimazolam, Propofol
- Volunteers
- 287 people
- Sponsor
- Sichuan Provincial People's Hospital
Anesthesia Complication, Hypotension on Induction
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
Intra operative hypotension is a risk factor in pediatric anesthesia (McCann ME et al.Pediatr Anesth 2014; 24: 68-73). In summary, the study aims at examine if ultrasound assessment of the diameter and collapsibility index of the…
- Conditions
- Anesthesia Complication, Hypotension on Induction, Hypovolemia
- Trial name
- NCT04573842
- Testing
- Ultrasound assessment of SCV
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Induction and Maintenance of General Anesthesia
A Study to Evaluate the Efficacy and Safety of HSK3486 in the Induction of General Anesthesia
This is a multi-center, randomized, single-blind, propofol injectable emulsion parallel-controlled Phase III clinical study. A total of patients undergoing elective surgery are intended to be enrolled and randomly assigned to…
- Trial name
- NCT04511728
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Hypotension, Induction of Anesthesia
Two Ratios of Propofol-ketamine Admixture for Rapid-sequence Induction Anesthesia for Emergency Laparotomy
Hypotension during anesthesia is associated with serious organ failure and death. The most critical period for intraoperative hypotension is the postinduction period during which, one-third of intraoperative hypotension occurs.
- Trial name
- NCT05166330
- Testing
- Ketofol equal ratio, Ketofol 1:3 ratio
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Kasr El Aini Hospital
Anesthesia, Intubation; Difficult or Failed
Paratracheal Esophagus Pressure on the Intubation With Pentax Airway Scope
Recently, left paratracheal pressure was introduced as an alternative method to prevent pulmonary aspiration instead of cricoid pressure.
- Conditions
- Anesthesia, Intubation; Difficult or Failed, Cricoid Pressure, Pulmonary Aspiration During Anesthetic Induction
- Trial name
- NCT04135651
- Testing
- Paratracheal pressure, Cricoid pressure
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Ajou University School of Medicine
Induction and Maintenance of General Anesthesia
A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients
This is a multi-center, randomized, open-label, positive-controlled (propofol) phase II clinical trial. The study plans to enroll approximately 46 eligible subjects.
- Trial name
- NCT04048811
- Testing
- HSK3486, Propofol, Propofol HSK3486
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Target Controlled Infusion, Induction of Anesthesia
Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance
The purpose of this study is to determine if a slow stepwise propofol TCI induction with Marsh model (Ke0 0.26), allows for an accurate estimation of the effect site concentration required for maintenance of the general…
- Conditions
- Target Controlled Infusion, Induction of Anesthesia, Bispectral Index
- Trial name
- (TITINDUC) (NCT02999126)
- Testing
- Propofol, Remifentanil Hydrochloride
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Induction of Anesthesia
A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of General Anesthesia in Elective Surgery Subjects
This is a multi-center, randomized, double-blind, propofol-controlled phase III clinical trial. The primary objective is to compare the efficacy and safety between propofol and HSK3486 for the induction of general anesthesia in…
- Trial name
- NCT03808844
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd