Clinical trials: Induction of General Anesthesia
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Continuous Positive Airway Pressure, Hypoxia
Positive Pressure at Induction of Anesthesia in Children
SCENARIO: Hypoxemia is one of the most common adverse events during the induction of general anesthesia and may culminate with more serious complications such as cardiac arrest and death.
- Conditions
- Continuous Positive Airway Pressure, Hypoxia, General Anesthesia
- Trial name
- NCT03432390
- Testing
- Continuous Positive Airway Pressure, Open system ventilation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Anesthesia, General
Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Required General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on Cardiovascular System in Common Clinical Practice
The main objective of this post-marketing observational study is to collect data from the use of general anesthesia in patients undergoing any surgery to create local recommendations.
- Trial name
- SEVOPROTECTION (NCT01282203)
- Where
- 12 sites in Kazakhstan
- Volunteers
- 1,122 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Igel
Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine
Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump.
- Trial name
- D-pofol (NCT02268656)
- Testing
- propofol concentration
- Volunteers
- 40 people
- Sponsor
- Gachon University Gil Medical Center
Cardiopulmonary Arrest, Respiratory Arrest
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life.
- Trial name
- EvK (NCT02643381)
- Testing
- Etomidate, Ketamine, Emergency Endotracheal Intubation
- Where
- United States
- Volunteers
- 801 people
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia
EEG Studies of Sevoflurane-Induced General Anesthesia
The investigators are performing this research study to find out how and where the anesthetic drugs sevoflurane and ketamine act in the brain.
- Trial name
- NCT03503578
- Testing
- Sevoflurane, Ketamine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia
The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
- Conditions
- Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia, Block Level, Gastrointestinal Surgery
- Trial name
- NCT02135016
- Testing
- 1% lidocaine, 2% lidocaine, 0.9% normal saline
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
Obesity, Morbid
EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
The risk of complication associated with airway in obese patient is important. The result of pre-oxygenation gives the clinician a prolonged non-hypoxic apnea time.
- Trial name
- EPO2-A (NCT02590406)
- Testing
- Beach chair (BC) and ZEEP, Reverse Trendelenburg and NIPPV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Anesthesia, General
Comparison of Sugammadex (Org 25969) With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 (P05960)
The purpose of this study was to demonstrate in adult participants faster recovery from a neuromuscular block induced by either rocuronium or vecuronium after reversal at reappearance of T2 (the amplitude of the first response of…
- Trial name
- NCT00451217
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 198 people
- Sponsor
- Merck Sharp & Dohme LLC