Clinical trials: Induction of Labor
Pregnancy, Eclampsia
A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
In many low-income countries, the use of ultrasound by medical officers and non-physician health care staff (e.g., midwives) for antenatal identification of high risk pregnancies is a new intervention requiring authoritative…
- Conditions
- Pregnancy, Eclampsia, Placenta Previa, Stillbirth
- Trial name
- NCT01990625
- Testing
- Antenatal Ultrasound Scan
- Where
- 5 sites in Guatemala, Kenya and 3 more
- Volunteers
- 45,038 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Induced; Birth
The REDUCED-I Pilot Trial: REDucing the Utilization of CEsarean Sections With Induction
This pilot project is a randomized controlled trial where induced patients receive an intervention of oxytocin discontinuation once in the active stage of labor (≥6 cm dilation).
- Trial name
- (REDUCED-I) (NCT05037617)
- Testing
- Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Induction of Labor Affected Fetus / Newborn
Early Versus Late Amniotomy Following EAB Cervical Ripening
The objective of this study is to investigate the course of labor in early versus late amniotomy following balloon cervical ripening in women undergoing term induction of labor stratified by parity.
- Trial name
- NCT04216628
- Testing
- Amniotomy
- Where
- Israel
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Assuta Ashdod Hospital
Augmentation, Induction
The Effect of Consumption of Date Fruit and Nipple Stimulation in Late Pregnancy
The study was conducted to determine the effect of consumption of date fruit and nipple stimulation on labor. The samples were applied to pregnant women satisfying the research criteria in a state hospital in Istanbul between…
- Conditions
- Augmentation, Induction, Labor, Stimulation, Self
- Trial name
- NCT06280911
- Testing
- Date Fruit group, Nipple group
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Labor, Induced, Cervix Uteri-Diseases
Comparing Outpatient to Inpatient Cervical Ripening Using Dilapan-S®
The target population for our study is women who present for induction of labor. If there is a decision by the obstetrical team to place a mechanical dilator for cervical ripening, the obstetrical team will notify the research…
- Trial name
- HOMECARE (NCT03665688)
- Testing
- Outpatient Dilapan-S, Inpatient Dilapan-S
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Labor, Induced
Oral Titrated Misoprostol for Induction of Labour
The purpose of this study is to compare effectiveness and safety of an oral titrated solution of misoprostol with vaginal misoprostol for induction of labour with an alive fetus.
- Trial name
- OTISMISO (NCT00992524)
- Testing
- Misoprostol
- Where
- Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Nicotine Dependence
Effects of Chantix on Relapse Prevention for Smoking Cessation
The goal of the proposed study is to validate an experimental paradigm to assess medication effects on smoking relapse following a brief (3-day) monitored period of smoking abstinence and a programmed cigarette lapse.
- Trial name
- NCT00948649
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiovascular Disease, Alcohol Use Disorder
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
The purpose of this research study is to investigate if a personalized intervention including parts such as navigation (focus on patient outreach efforts, missed and completed encounters), personalization (individual health…
- Conditions
- Cardiovascular Disease, Alcohol Use Disorder, HIV Risk, Substance Use Disorders
- Trial name
- NCT05828849
- Testing
- Navigation, compensation, and personalization
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pregnancy, Induction of Labor
Transcervical Foley Catheter With or Without Oxytocin for Induction of Labor
The purpose of the present study is to evaluate the possible benefit of concurrent IV Oxytocin infusion with trans cervical Foley catheter for pre-induction cervical ripening.
- Trial name
- NCT00684606
- Testing
- Oxytocin IV
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Induced Vaginal Delivery
Tension Versus Tension- Free Foley Balloon for Cervical Ripening
Foley balloons are commonly used as a mechanical method of cervical ripening for induction of labor. Foley balloons may be placed either under tension or without tension (tension-free).
- Trial name
- NCT05404776
- Testing
- Placement of Foley balloon for cervical ripening with tension., Placement of Foley balloon for cervical ripening without tension.
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Labor Fast
Isosorbide Mononitrate in Induction of Labour
Induction of labor is defined as the process of artificially initiating uterine contractions, prior to their spontaneous onset, with progressive effacement and dilatation of the cervix and ultimately, the delivery of the baby.
- Trial name
- NCT04482881
- Testing
- Isosorbide Mononitrate 40 MG, Isosorbide Mononitrate 60 MG, Misoprostol
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Early Amniotomy, Unfavorable Cervix
Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial
This study evaluates the effectiveness and safety of early amniotomy after vaginal prostaglandin E2 for induction of labor at term.
- Trial name
- PGE2 (NCT02856724)
- Testing
- PGE2
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Induction of Labor
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Multiparous
The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in multiparous women.
- Trial name
- NCT06335017
- Testing
- Induction of labor
- Where
- Israel
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Labor Induction
Foley Catheter Versus Cervidil for Induction of Labor at Term
OBJECTIVE: To assess the efficacy of transcervical Foley catheter compared to controlled release prostaglandin (Cervidil™) for cervical ripening in term and near term women presenting for labor induction.
- Trial name
- NCT01402050
- Testing
- CERVIDIL (Dinoprostone), FOLEY BALLOON
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Infections
Azithromycin Before Induction
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and…
- Trial name
- NCT06543290
- Testing
- Azithromycin Pill
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Arrowhead Regional Medical Center
Induction of Labor, Transvaginal Ultrasound: Cervical Sliding Sign
Cervical Sliding Sign to Predict Outcome of Induction of Labor
Assess the role of transvaginal ultrasound specifically a sign called cervical sliding sign, in the prediction of success of induction of labor.
- Trial name
- NCT06324279
- Testing
- Transvaginal ultrasound, Misoprostol 200mcg Tab
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Induction of Labor
Labor Induction With Dinoprostone in Oppose to Cervical Ripening Balloon as a Factor of BMI.
Women with a BMI>30 and women with a BMI<30 will be divided in a randomized controlled manor to 4 groups depending on the mode of labor induction and BMI value: 1. Dinoprostone in women with a BMI>30. 2.
- Trial name
- NCT03033264
- Testing
- Dinoprostone, Double lumen cervical ripening balloon.
- Where
- Israel
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Labor, Induced
Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter
This prospective, randomized, double-blind controlled trial aims to evaluate whether intravenous papaverine, administered immediately after the removal of a double-balloon catheter used for cervical ripening, can shorten the…
- Trial name
- NCT07237880
- Testing
- Papaverine 80 mg IV
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Labor Induction
BMI-Associated Labor Induction: A Prospective Trial
The primary objective of this study is to determine if planned induction of labor at 39 weeks for nulliparous with pre-pregnancy BMI ≥ 35 kg/m2 reduces the incidence of cesarean section compared to expectant management
- Trial name
- BALI (NCT04035382)
- Testing
- Labor induction
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center