Clinical trials: Induction of Ovulation
Polycystic Ovarian Syndrome
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and…
- Trial name
- NCT06813118
- Testing
- Clomiphene Citrate and letrozole
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- HITEC-Institute of Medical Sciences
Poor Response to Ovulation Induction Poseidon Type IV
Growth Hormone Pretreatment in Poseidon Type IV Undergoing ICSI Using Minimal Induction Protocol: A Randomized Controlled Trial
This study is done aiming to Assess Efficiency of Growth hormone as an adjuvant in pretreatment of Poseidon type IV group " poor responders "undergoing ICSI using minimal induction protocol
- Trial name
- Growth hormone (NCT05089344)
- Testing
- Growth Hormone, Clomiphene citrate daily and recombinant FSH (Gonal-F®)
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
PCOS
Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting approximately 6-10% of women of reproductive age.
- Trial name
- NACIPCOS (NCT01896492)
- Testing
- NAC
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Infertility
Endometrial Shedding Prior to Ovulation Induction Pilot Study
This is a pilot study examining the feasibility of implementing a large randomized control trial looking at the effect of endometrial shedding with medroxyprogesterone acetate compared to no pre-treatment in women taking…
- Trial name
- NCT02340013
- Testing
- Medroxyprogesterone acetate
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Polycystic Ovary Syndrome
Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome
The Polycystic Ovarian Syndrome (PCOS) is a common disorder related to ovulation problems. Clomiphene citrate (CC) is the drug of first choice for this condition.
- Trial name
- NCT00427700
- Testing
- clomiphene citrate, raloxifene
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Compare Pregnancy Rates Between FSH Stimulation and FSH and, GnRH Antagonist
Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles
Ovulation induction (OI) using gonadotropins is one of the most widely prescribed treatments of infertility. One common problem encountered while attempting OI using gonadotropins is premature ovulation.
- Trial name
- NCT01286051
- Testing
- Follistim administration, Follistim plus Ganirelix
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Houston Fertility Institute
Ovulation Induction, Polycystic Ovary Syndrome
Effect of Adding Isoflavonoids to Clomiphene Citrate for Ovulation Induction in Women With Polycystic Ovary Syndrome
This prospective, randomized clinical trial double blinded study, has been carried on 160 infertile patients seeking pregnancy in Gynecology and Obstetrics Department, Zagazig University Hospitals during the period from January…
- Trial name
- NCT04610957
- Testing
- Rosafem (FEMININE FORMULA)
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- FAlbasri
IVF Poor Responders
Optimizing Ovulation Induction in the Poor Responder
The purpose of this randomized controlled trial is to compare the efficacy and effect of luteal estradiol and combined oral contraceptive pills (COPC) on follicle recruitment and synchrony in a poor responder population.
- Trial name
- NCT01200537
- Testing
- Estradiol, Oral Contraceptive Pills (OCP)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Infertility
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.
- Trial name
- NCT01046708
- Testing
- micronized progesterone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Fertility Disorders
Injection Free IVF
Investigation of Natural Cycle In vitro Fertilisation (NC-IVF) treatment with ovulation induction with a nasal GnRH agonist instead of regular NC-IVF treatment with subcutaneous application of hCG with the objective of increasing…
- Trial name
- NCT04850261
- Testing
- hCG Injection, Nafarelin nasal spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Polycystic Ovary Syndrome
Combined Chromium With Letrozole Versus Letrozole Only in Induction of Ovulation in Patients With Polycystic Ovary Syndrome
Combined letrozole with chromium versus letrozole only in induction of ovulation in polycystic ovary syndrome
- Trial name
- NCT05765305
- Testing
- Letrozole with chromium
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Luteal Phase Insufficiency
Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels.
- Trial name
- CineP4 (NCT07028710)
- Testing
- hCG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Infertility, Ovarian Hyperstimulation Syndrome
Monitoring the Early Follicular Phase With Androstenedione in Low-dose Step-up Ovulation Induction in High Responders
This study aims to predefine the threshold FSH doses during the early follicular phases in low- dose step-up ovulation induction cycles used to treat anticipated high responders by monitoring total testosterone and…
- Trial name
- NCT02329483
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Polycystic Ovary
Clomiphene Citrate Stair-Step Protocol
A RCT will be conducted to compare the traditional clomiphene citrate regimens for ovulation induction with the stair-step protocol.
- Trial name
- NCT03178500
- Testing
- Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Polycystic Ovarian Syndrome
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
As both medications i.e. CC and letrozole have been shown to be effective in inducing ovulation in PCOS patients, this study was performed in order to evaluate which regime (whether CC or letrozole) is the best to be used as the…
- Trial name
- NCT01577017
- Testing
- Letrozole
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nik Hazlina
INFERTILITY, Fertility Preservation
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors .
- Conditions
- INFERTILITY, Fertility Preservation, Ovulation Induction, Vitrification
- Trial name
- NCT01645241
- Testing
- gonadotropins plus GnRH antagonists, ganirelix
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Infertility
Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs
hCG and GnRH agonist can be used to induce final oocyte maturation and ovulation in IVF cycles. These two approaches will be compared in this study in terms of pregnancy rates and embryological data using patients with…
- Trial name
- NCT00415792
- Testing
- Arvekap, Pregnyl
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eugonia
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing