Clinical trials: Infant,Premature
Preterm Infants
Light/Dark Cycle Promotes Weight Gain in Preterm Infants
The study focuses on the use of light/dark alternation as chronotherapy to prevent deterioration and reduce morbidity and mortality in premature patients, as well as favoring circadian alteration after birth, which should lead…
- Trial name
- NCT05230706
- Testing
- Cephalic helmet
- Volunteers
- 300 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Neonatal İntensive Care, Nutrition With A Chronobiological Approach
The Effect of PIOMI and Chronobiological Nutrition on Readiness for Feeding, Full Transition to Oral Feeding and Body Weight
This is a randomized controlled experimental study evaluating the effects of oral motor intervention and chronobiological approach to feeding model applied to preterm infants on feeding readiness, transition to total oral feeding…
- Conditions
- Neonatal İntensive Care, Nutrition With A Chronobiological Approach, Readiness For Feding, Body Weight
- Trial name
- PIOMI (NCT07306793)
- Testing
- PIOMI study group, Nutrition Study Group with a Chronobiological Approach, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Hypothermia in Premature Infants
Multicentre Randomised Controlled Trial of HELP (Heat Loss Prevention) in the Delivery Room
Does polyethylene occlusive wrap applied immediately after delivery to infants born at less than 28 weeks gestation decrease all-cause mortality measured at discharge compared with the standard of care as determined by the…
- Trial name
- HeLP (NCT00607464)
- Testing
- Polyethylene occlusive skin wrap
- Where
- Canada
- Volunteers
- 804 people
- Sponsor
- Sunnybrook Health Sciences Centre
Low Breast Milk Supply
Effect of Domperidone on the Nutrient Composition of Preterm Mother's Breast Milk
The purpose of this study is to evaluate the effect of domperidone (given to lactating mothers of very preterm infants) on the macronutrient composition of human milk.
- Trial name
- NCT00308334
- Testing
- Domperidone
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- IWK Health Centre
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant
IgM-Enriched Immunoglobulin for Neonatal Sepsis
This study compares giving prophylactic IgM enriched Intravenous Immunoglobulin (IVIG) with placebo in 1 hour after birth, in neonates with risk factors of Early-Onset Neonatal Sepsis (EONS).
- Conditions
- Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant, Inflammation, Infant, Newborn, Disease
- Trial name
- NCT04041765
- Testing
- IgM-enriched IVIG
- Volunteers
- 70 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Anemia
Effect of Maternal Hemoglobin on Neurobehavioural Development of Late Preterm Neonates : A Cohort Study
The study entitled 'Effect of maternal hemoglobin on neurobehavioral development of late preterm neonates' was done with an objective to determine whether low maternal hemoglobin (<11gm/dl), in late preterm neonates(>34weeks but…
- Trial name
- NCT02840292
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Lady Hardinge Medical College
Patent Ductus Arteriosus
Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure
Using cerebral and renal near infrared spectroscopy monitoring to determine PDA closure in preterm infants after completing medical treatment for a hemodynamically significant PDA.
- Trial name
- NCT03026192
- Testing
- near infrared spectroscopy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Premature Birth
Facilitating Safe Transition to Home for Preterm Infants - a National Database Study
Preterm infants (i.e. born before 37 completed weeks of pregnancy) often require additional care and are admitted to neonatal units.
- Trial name
- NCT06284044
- Where
- United Kingdom
- Volunteers
- 250,000 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Preterm Infant Development, Preterm Infant Health
Pilot Study: Effects of CCP Intervention on NICU Environment and Preterm Infants Development
Close Collaboration with Parents intervention is an evidence-based educational intervention for the entire multi-professional staff of neonatal intensive care units (NICUs).
- Trial name
- NCT07306000
- Testing
- Close Collaboration with Parents training
- Where
- 3 sites in Japan, South Korea
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Respiratory Distress, Lung Injury
Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP
This study is designed to evaluate the effect of heated humidified high flow nasal cannula (HHHFNC) as compared to noninvasive nasal continuous positive airway pressure (NCPAP) on lung function as a measure of lung injury in…
- Trial name
- NCT01939067
- Testing
- Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Low Birth Weight Infant, Enteral Nutrition
Oral Versus Intravenous Rehydration for Prevention of Dehydration in Premature Babies, During the First Days of Life.
This prospective randomised study comparing administration of a hypo-osmolar oral hydration solution with the classical hydration via IV (intravenous) infusion in premature infants of more than 32 weeks GA (gestational age) aims…
- Trial name
- SROPREMA (NCT00715000)
- Testing
- Oral rehydration therapy, classical hydration via intravenous infusion
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infant, Premature, Patent Ductus Arteriosus
Management of the PDA Trial
Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.
- Conditions
- Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
- Trial name
- PDA (NCT03456336)
- Testing
- Active Treatment, Expectant Management
- Where
- 19 sites in United States
- Volunteers
- 482 people
- Sponsor
- NICHD Neonatal Research Network
Premature Infant, Mother-Baby Synchrony
Reading Stories to Premature Babies Reinforces Mother-baby Synchronies?
Observations of the early interactions between the infant and his parents highlighted the existence of rhythmic and reciprocal communications that serve as a basis for the mother-baby relationship and the emotional and cognitive…
- Trial name
- SynchroPrema (NCT03114644)
- Testing
- Physiologically evaluate the impact of reading history on the mother-baby synchronies in a context of premature birth requiring hospitalization in neonatal medicine.
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Safety Issues, Effect of Drugs
Safety of Autologous Cord Blood Cells for Preterm Infants.
To assess the safety of autologous volume- and red blood cell (RBC)-reduced non-cryopreserved umbilical cord blood (UCB) cell infusion to preterm infants.
- Conditions
- Safety Issues, Effect of Drugs, Neonatal Death
- Trial name
- NCT03760900
- Testing
- Autologous Umbilical Cord Blood Stem Cells Therapy
- Volunteers
- 15 people
- Sponsor
- Guangdong Women and Children Hospital
Very Preterm Infant, Necrotizing Enterocolitis (NEC)
Effects of Enteral Feeding Regimens on NEC, Mortality, and Neurodevelopment in Very Preterm Infants
The goal of this clinical trial is to evaluate whether supplementing with pasteurized donor human milk (pHDM) or preterm formula (PTF) when own mother's milk (OMM) is insufficient can improve outcomes in very preterm infants born…
- Trial name
- NCT07045844
- Testing
- Pasteurized Donor Milk for Insufficient Breastfeeding, Preterm Formula for Insufficient Breastfeeding, Routine fortification
- Where
- 24 sites in China
- Volunteers
- 2,324 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Retinopathy of Prematurity
Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Retinopathy of Prematurity (ROP) screening is one of many potentially painful diagnostic and therapeutic procedures performed routinely on preterm infants in the Neonatal Intensive Care Unit.
- Trial name
- NCT00921544
- Testing
- Sucrose, Sterile water
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Coombe Women and Infants University Hospital
Premature Birth
A Family-Centered Intervention Program for Preterm Infants: Effects and Their Biosocial Pathways
Four hypotheses will be tested in this study: 1. The intervention group performs better in child, parent and transactions outcomes than the control group throughout the follow-up period. 2.
- Trial name
- NCT01807533
- Testing
- Family-centered intervention program, Usual care intervention program
- Where
- 3 sites in Taiwan
- Volunteers
- 275 people
- Sponsor
- National Taiwan University Hospital
Premature Birth
Association Between Mother-Infant Attunement During Interaction and the Quality of General Movements
The proposed research has the potential of contributing to the limited empirical literature on the relationship between maternal sensitivity and motor development of preterm infants.
- Trial name
- NCT01764958
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Infant, Premature, Bronchopulmonary Dysplasia
Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease
The purpose of this study is to evaluate how easily gas can be taken up by the lung. We are comparing infants born premature <32 weeks gestation to infants born full term >37 weeks.
- Conditions
- Infant, Premature, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00428038
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Indiana University