Clinical trials: Infant Development, open to volunteers
Neurodevelopmental Disorders, Motor Skills Disorders
Motor Development and Early Predictors of Psychomotor Outcomes in Preterm and Term Infants Assessed by MOS-R and Caregiver Questionnaire at 18 and 36 Months
This study examines how early motor behavior in infants relates to their later psychomotor development. Researchers will observe both preterm and full-term infants during the first months of life, using video-based assessments to…
- Conditions
- Neurodevelopmental Disorders, Motor Skills Disorders, Infant, Premature Development, Infant, Term Development
- Trial name
- NCT07296003
- Testing
- Vojta method
- Where
- 3 sites in Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Bronchopulmonary Dysplasia, Preterm Infant Development
PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks.
- Conditions
- Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis
- Trial name
- PremaBiom (NCT07411261)
- Testing
- Nasal swab, blood sampling, Mother milk sampling
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen
Brain Development, Behavior Disorders, Child
The Brain Mechanism of Social Emotion and Communication in Infants Aged 0 to 6 Years
This study explores the relationship between brain development and infants' social emotion and communication ability, as well as the role of genetic factors and maternal exposure during pregnancy (e.g., environmental exposures…
- Conditions
- Brain Development, Behavior Disorders, Child, Intellectual Developmental Disorders
- Trial name
- NCT05040542
- Testing
- maternal exposure during pregnancy
- Where
- China
- Volunteers
- 3,001 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Child Development, Infant Development
Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants
This study will test the hypothesis that in preterm infants a caregiver-implemented early developmental intervention (EDI) using finger puppets to develop joint attention and encourage interactive communication with routine EDI…
- Conditions
- Child Development, Infant Development, Infant, Premature, Diseases
- Trial name
- IMPACT (NCT06335524)
- Testing
- Finger puppet, Bookworm reading intervention training and routine EDI care.
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- University of Alabama at Birmingham
Cholestasis in Newborn, Biliary Atresia
The Dirty Nappy Study
This observational study evaluates whether a machine-learning algorithm, a computer program that learns patterns from data, can accurately diagnose cholestasis in newborns.
- Conditions
- Cholestasis in Newborn, Biliary Atresia, Neonatal Cholestasis
- Trial name
- NCT07697872
- Where
- United Kingdom
- Volunteers
- 5,350 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Healthy Newborn Infants
Impact of Delivery Mode on Infant Gut Microbiota, Visceral Sensitivity, and the Neuroenteric System
The bacteria and other microorganisms that naturally live in the gut (the gut microbiome) play an important role in a baby's early development.
- Trial name
- CROSS-TIVITY (NCT07899333)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Sleep Problem, Neurobehavioral Manifestations
NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood
The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important…
- Trial name
- NapBiome (NCT06396689)
- Testing
- Synbiotic
- Where
- 2 sites in Switzerland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Petra Zimmermann
Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder
Home Play-based Intervention for Parents and Infants
The goal of this clinical trial is to learn whether a 12-week home-based intervention (Sociometric Play-based Remediation of Individual Neurodevelopmental Trajectories (SPRINT)) helps support parenting and the development of…
- Conditions
- Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder, Premature Birth, Global Developmental Delay
- Trial name
- SPRINT (NCT07716072)
- Testing
- SPRINT Intervention, Waitlist Protocol
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Nanyang Technological University
Premature Baby, Neurocognition, Child
Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception
From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex…
- Trial name
- Pré-AV (NCT07245693)
- Testing
- Audiovisual association capability tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Prematurity
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
Infants born preterm can spend months in the neonatal intensive care unit (NICU) where they experience stressful but essential procedures. Untreated stress is associated with altered brain development.
- Trial name
- NCT04911452
- Testing
- Calmer
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Cerebral Palsy, Cerebral Palsy Early Intervention
Early Intervention in Cerebral Palsy: Perception-Action vs Neurodevelopmental Therapy
The goal of this clinical trial is to compare two different physiotherapy approaches used in early intervention for children with cerebral palsy.
- Trial name
- NCT07575659
- Testing
- Perception-Action Approach, Neurodevelopmental Therapy (Bobath)
- Volunteers
- 24 people
- Sponsor
- Tuba Derya Doğan
Premature Birth
Development of a Therapeutic Device to Improve Speech Sound Differentiation in Preterm Infants
The goal of this clinical study is to test a new, novel medical device designed to improve speech sound differentiation among hospitalized preterm infants.
- Trial name
- NCT06063122
- Testing
- smallTalk NICU Active
- Where
- 2 sites in United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Thrive Neuromedical, LLC
Growth & Development, Breastfeeding Satisfaction
Effectiveness of a Counseling Program on Exclusive Breastfeeding Rates in a Primary Care Center
Introduction: Evidence supports that exclusive breastfeeding (EBF) is the most beneficial method of infant feeding up to 6 months of age. The practice confers numerous advantages for the infant and the mother.
- Conditions
- Growth & Development, Breastfeeding Satisfaction, Breastfeeding Consultancy Training, Breastfeeding Duration
- Trial name
- ALM-AP (NCT07309510)
- Testing
- breastfeeding counseling
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Fundación Pública Galega de Investigación Biomédica INIBIC
Autism Disorder
The Effectiveness of a Parent Training Program for Children With Autism Spectrum Disorder and High-Risk Infants: A Case-Control Study
The aim of this study is to evaluate the effectiveness of a parent training program on the severity of autism-related symptoms in two groups: (1) infants under the age of 2 who show early signs of autism, and (2) children aged 2…
- Trial name
- PTP (NCT07075614)
- Testing
- Parent Training Program, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Umraniye Education and Research Hospital
Depression - Major Depressive Disorder
Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression
The goal of this study is to examine attentional biases for facial displays of emotion as a mechanism of risk in infants of mothers with postpartum major depression, and the potential role of infant arousal in the development of…
- Trial name
- NCT06835855
- Testing
- Passive Viewing Task, Interaction Task
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Autism Spectrum Disorder
Duration of Moment in Autism
This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink.
- Trial name
- DOMA (NCT07384819)
- Testing
- Temporal Integration Window task, Attentional Blink task
- Where
- 2 sites in France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Apnea of Prematurity, Intermittent Hypoxemia
The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants
The aim of this proposal is to characterize the acute effect of early postnatal sound exposure on neuronal maturation of the respiratory control regions of the brain in preterm infants.
- Conditions
- Apnea of Prematurity, Intermittent Hypoxemia, Bradycardia
- Trial name
- NCT05298748
- Testing
- Womb sound recordings
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Case Western Reserve University
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Income, Infant, Newborn
Integrating Systems and Basic Income: Improving Outcomes for Families of Young Children
Early childhood is a critical period, laying the foundation for future growth and deveopment. This foundational period has an outsized effect, impacting health, well-being and achievement across one's lifespan. The U.S.
- Conditions
- Income, Infant, Newborn, Mothers, Poverty
- Trial name
- NCT07261254
- Testing
- Community Health Worker, Community Health Worker + Guaranteed Basic Income
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- Stanford University
Puberty
Minipuberty of Infancy and the Timing of Pubertal Development in Adolescence: a Follow-up of the Infant Feeding and Early Development (IFED) Cohort
Background: Earlier puberty is associated with adverse health throughout a person s life. The average age when puberty begins has been declining over the past decades in girls, and may also be declining in boys.
- Trial name
- NCT05463120
- Where
- 2 sites in United States
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)