Clinical trials: Infant and Young Children
Malaria
Revaccination of Young Children With Bacille Calmette Guerin (BCG) Vaccine
BCG has marked immune stimulatory effects in both animal and human studies and observational studies suggest that BCG is associated with a non-specific reduction in mortality in areas with high infant and child mortality.
- Trial name
- NCT00126217
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,871 people
- Sponsor
- Bandim Health Project
Vitamin B 12 Deficiency
Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems
During fetal life and infancy, an adequate cobalamin status is important for normal growth and central nervous system development.
- Trial name
- NCT00710359
- Testing
- Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma)
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Duchenne Muscular Dystrophy
Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy
While it has been known for many years that corticosteroid use benefits boys with Duchenne Muscular dystrophy (DMD), most clinicians do not consider treating until after age 3 or 4 years of age.
- Trial name
- NCT02167217
- Testing
- Prednisolone
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Trauma
The Effects of the Anesthetic Ketamine in Young Children Undergoing Procedural Sedation
In the emergency department (ED), ketamine is a popular anesthetic agent during sedation of children for painful and other short procedures.
- Trial name
- NCT02650154
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- The Hospital for Sick Children
Medulloblastoma
Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma
This is a multi-center, multinational phase 2 trial that aims to explore the use of molecular and clinical risk-directed therapy in treatment of children 0-4.99 years of age with newly diagnosed medulloblastoma.
- Trial name
- NCT05535166
- Testing
- Surgical resection, Ommaya/VPS, Methotrexate
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- St. Jude Children's Research Hospital
Haematological Malignancy, Acute Leukemia
A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts
To date, allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes, haemoglobinopathies…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT04331483)
- Testing
- Physical activity program
- Where
- France
- Sponsor
- Centre Leon Berard
Maternal Mental Health, Early Child Development
Mental Health Support Interventions for Mothers of Infants and Young Children
The goal of this clinical trial is to learn whether a maternal mental health support program can improve maternal mental health and child development when delivered through routine child healthcare services in community health…
- Conditions
- Maternal Mental Health, Early Child Development, Depressive Symptoms, Postpartum
- Trial name
- NCT07627373
- Testing
- Thinking Healthy Extended Program
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Stanford University
Poliomyelitis
Study of a Novel Type 3 Oral Poliomyelitis Vaccine in Panama
The purpose of this clinical trial is to assess the safety and tolerability (primary objective), immunogenicity (primary and secondary objectives), fecal shedding of vaccine viruses (secondary objective) and the potential for…
- Trial name
- NCT05654467
- Testing
- Novel Live Attenuated Type 3 Oral Poliomyelitis Vaccine (nOPV3), Sabin Monovalent Oral Poliomyelitis Vaccine Type 3 (mOPV3)
- Where
- 3 sites in Panama
- Volunteers
- 1,532 people, healthy volunteers welcome
- Sponsor
- PATH
Scabies
Comparison of Permethrin-Based Treatment Strategies Against Scabies in Infants and Young Children
To compare the efficacy of different permethrin-based therapies for scabies infestations in infants and young children.
- Trial name
- NCT07247630
- Testing
- Permethrin 5%
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Growth Failure, Good Infant and Young Child Feeding Practices
Joint Infant and Young Child Nutrition Program and Malnutrition Prevention
Study title: Joint Infant and young children nutrition program in Burkina Faso: Impact evaluation Hypothesis: The fortification of complementary foods associated with a counseling on feeding practices for infants and young…
- Trial name
- NCT02136966
- Testing
- MNP + IYCN counseling + cooking demonstrations
- Where
- Burkina Faso
- Volunteers
- 2,212 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Energy Expenditure, Body Composition
Energy Expenditure and Body Composition of Infants and Young Children (6-24 Months Old) in Asia
This project is a collaboration between International Atomic Energy Agency (IAEA), FAO Regional Office for Asia and The Pacific, and Mahidol University, Thailand to carry out the study on doubly-labeled water for assessment of…
- Conditions
- Energy Expenditure, Body Composition, Infants and Young Children, Infant and Young Child Feeding
- Trial name
- NCT06287697
- Testing
- No intervention
- Where
- Thailand
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cystic Fibrosis With Mild to Moderate Lung Disease, CMRI of Lung Perfusion
Sildenafil Trial in Children and Young Adults With CF
Cystic Fibrosis (CF), the most common inherited disease in Caucasians, is characterized by chronic pulmonary inflammation and progressive loss of gas exchange units that eventually results in respiratory failure.
- Conditions
- Cystic Fibrosis With Mild to Moderate Lung Disease, CMRI of Lung Perfusion, Lung Perfusion, Lung Vascularization
- Trial name
- NCT01194232
- Testing
- Sildenafil
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Malnutrition, Infant, Malnutrition, Child
Efficacy of Mobile Health Application in Promotion of Exclusive Breast Feeding and Young Child Feeding Practices in Pakistan
Early life nutrition is the key modifiable determinant of child growth, development, survival and diseases of adult onset. Pakistan ranks highest for neonatal mortality rate (44.2/1000 live births (LBs)) globally.
- Trial name
- NCT05590351
- Testing
- First diet: m-health coaching application, Face to Face counselling
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Malnutrition
Acceptability of LNS for Infants and Young Children in Guatemala
This study aims to assess the acceptability of lipid-based nutrient supplements (LNS) for use as nutritional supplements for infants and young children in Guatemala. The study was conducted in three phases.
- Trial name
- NCT01148641
- Testing
- LNS
- Where
- Guatemala
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Education on Feeding and Health Status
To Evaluate the Effect of Nutrition Education on Infants and Young Children's Nutritional and Health Status in East Wollaga Zone
Child undernutrition is the principal cause of child morbidity and mortality worldwide. It manifests in different forms including stunting, wasting, underweight, and micronutrient deficiencies.
- Trial name
- NCT05503654
- Testing
- Nutrition education
- Where
- Ethiopia
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Jimma University
Healthy Children
Study to Evaluate the Effects of a Formula on the Gut Health of Healthy Chinese Infants and Young Children
The infant gut microbiota, a major driver of the maturation of the immune system, is formed through the successive establishment and development during infancy and early childhood.
- Trial name
- NCT04864665
- Testing
- a formula with prebiotics and milk fat
- Where
- 6 sites in China
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Malnutrition in Children
Women Supporting Women to Improve Infant and Child Feeding Practices in Pakistan
This project aims to reduce child malnutrition in Pakistan by building on local strengths and practical community solutions. The project focuses on children 7-23 months of age.
- Trial name
- NCT07345754
- Testing
- 28-day Behavioural Change Program
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- University of British Columbia
Electroencephalography, General Anesthesia
Multi-center Isoelectric EEG Study in Children Under General Anesthesia
Multi-center, prospective, observational study investigating the incidence of isoelectric electroencephalography (EEG) events and the associated peri-operative factors in infants 0-3yo undergoing general anesthesia.
- Conditions
- Electroencephalography, General Anesthesia, Pediatric Anesthesia
- Trial name
- NCT03432351
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 687 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia