Clinical trials: Infant and Young Children
Child Malnutrition, Behavior, Maternal
Mobile Gaming App to Improve Child Nutrition in Nigeria
Undernutrition among children born to teenage mothers deserves urgent attention in Nigeria, where 27.2% of girls (15-19 years) living in rural areas have begun childbearing.
- Trial name
- NCT05181293
- Testing
- Mobile Gaming App for Nutrition Intervention
- Where
- Nigeria
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stunting
Child Health, Agriculture and Integrated Nutrition
CHAIN is an open-label, individually randomized trial of improved infant and young child feeding (IYCF) versus "IYCF-plus" among 192 infants enrolled between 5-6 months of age in Shurugwi district, rural Zimbabwe.
- Trial name
- CHAIN (NCT04874688)
- Testing
- Small-quantity lipid-based nutrient supplement, Provitamin A biofortified maize, NUA-45 biofortified sugar beans
- Where
- Zimbabwe
- Volunteers
- 192 people
- Sponsor
- Queen Mary University of London
Acquired Immunodeficiency Syndrome, Tuberculosis
Pharmacokinetics of Lopinavir/Ritonavir Superboosting in Infants and Young Children Co-infected With HIV and TB
The purpose of this study is to determine the lopinavir levels in blood of HIV and TB infected children (3-15kg) when given lopinavir/ritonavir in a 1:1 ratio with rifampicin containing TB regimen and its safety.
- Trial name
- NCT02348177
- Testing
- lopinavir with ritonavir in 1:1 ratio, Lopinavir/ritonavir 4:1
- Where
- 5 sites in South Africa
- Volunteers
- 96 people
- Sponsor
- Drugs for Neglected Diseases
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations
Regeneron is conducting a study of an investigational new drug called DB-OTO. DB-OTO is a gene therapy that is being developed to treat pediatric and adult participants who have severe-to profound and profound hearing loss due to…
- Trial name
- CHORD (NCT05788536)
- Testing
- DB-OTO
- Where
- 17 sites in United States, Germany and 3 more
- Volunteers
- 36 people
- Sponsor
- Regeneron Pharmaceuticals
Respiratory Syncytial Virus Infection
Clinical Study of Palivizumab in Japanese Newborns, Infants and Young Children at the Age of 24 Months or Less With Immunocompromised Medical Conditions
To evaluate safety, efficacy and pharmacokinetics of palivizumab in children at the age of 24 months or less with immunocompromised medical conditions.
- Trial name
- NCT01466062
- Testing
- Palivizumab
- Where
- 6 sites in Japan
- Volunteers
- 28 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Evaluations
Supporting Optimal Infant, Young Child and Maternal Nutrition and Health in Jordan: An Evaluation of the CHN Program
The purpose of the comprehensive evaluation is to assess USAID supported Community Health and Nutrition (CHN) program's ability to effect change, the comprehensive evaluation will assess the effectiveness of CHN in influencing…
- Trial name
- NCT05365698
- Testing
- Community Health and Nutrition Program
- Where
- Jordan
- Volunteers
- 1,145 people
- Sponsor
- Tufts University
Child Malnutrition, Breastfeeding
Impact of Behavior Change Communications and Market-based Approach to Delivering Micronutrient Powders on Stunting, Infant Feeding Practices and Anemia in Bangladesh
This complex evaluation of a large-scale program uses a cluster-randomized design where 20 geographic clusters (subdistricts) were randomized to study two sets of interventions.
- Conditions
- Child Malnutrition, Breastfeeding, Complementary Feeding, Childhood Anemia
- Trial name
- NCT01678716
- Testing
- EHC + BCC, Micronutrient powders, Mass media
- Where
- Bangladesh
- Volunteers
- 8,800 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Malaria,Falciparum
Safety and Immunogenicity of ChAd63 RH5 and MVA RH5 in Adults, Young Children and Infants Living in Tanzania
This is a dose-escalation, age de-escalation randomised double-blind controlled Phase Ib trial to assess the safety, tolerability and immunogenicity of ChAd63-RH5 administered with MVA-RH5 in a heterologous prime-boost regimen.
- Trial name
- NCT03435874
- Testing
- ChAd63 RH5, MVA RH5, Rabies Vaccine
- Where
- Tanzania
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nutritional Stunting
Education Using WhatsApp and Face-to-Face Meetings on IYCF for the Nutritional Status of Infants
The COVID-19 pandemic affects all activities, including stunting prevention. Almost all cities implement Internet-based learning can be used as an alternative to providing education and allows to exchange personal experiences and…
- Trial name
- NCT05502978
- Testing
- Blended education of Infant and Young Child Feeding
- Where
- 3 sites in Indonesia
- Volunteers
- 126 people
- Sponsor
- Gadjah Mada University
Malaria
Revaccination of Young Children With Bacille Calmette Guerin (BCG) Vaccine
BCG has marked immune stimulatory effects in both animal and human studies and observational studies suggest that BCG is associated with a non-specific reduction in mortality in areas with high infant and child mortality.
- Trial name
- NCT00126217
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,871 people
- Sponsor
- Bandim Health Project
Iron Deficiency in Young Children Living in France
Iron Deficiency (ID) in Infants
ID in children is the most frequent micronutrient deficiency in industrialized countries, including France. ID induces neurological impairment reducing cognitive, motor, and behavioral capacities in children in the short and long…
- Trial name
- CARMA (NCT02484274)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 830 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia, Acute Lymphoblastic
A Treatment Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
The pilot study collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new platform protocol, which is both a comprehensive…
- Trial name
- NCT03911128
- Testing
- Observational
- Where
- 57 sites in Denmark, Estonia and 6 more
- Volunteers
- 500 people
- Sponsor
- Mats Heyman
Malnutrition
Food and Agricultural Approaches to Reducing Malnutrition
The aim of this study is to evaluate the potential of reducing young child undernutrition in low-income countries through an integrated program that trains women's groups in agriculture, nutrition, child care and hygiene.
- Trial name
- FAARM (NCT02505711)
- Testing
- Homestead Food Production program
- Volunteers
- 2,705 people, healthy volunteers welcome
- Sponsor
- Sabine Gabrysch
Healthy, Cystic Fibrosis (CF)
MRI for Non-Invasive Imaging in Neonates and Children
The purpose of this study is to develop rapid MRI techniques for imaging the lung with hyperpolarized helium-3 gas as an inhaled contrast agent.
- Conditions
- Healthy, Cystic Fibrosis (CF), Asthma, Bronchopulmonary Dysplasia (BPD)
- Trial name
- NCT02163681
- Testing
- Hyperpolarized Helium-3 MRI of the chest
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Infant Growth
Growth and Health Efficacy of Novel Infant Formula : A Randomized Trial
Randomized, controlled study consisting of three parallel arms to investigate the effects of novel infant formula on growth, gut health, immune function, and sleep status in healthy infants and young children aged 12-18 months.
- Trial name
- NCT07534735
- Testing
- Investigational Formula 1, Investigational Formula 2
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Biostime (Changsha) Nutrition Foods Limited
Achondroplasia
A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia
Study 111-206 is a Phase 2 randomized, double-blind, placebo-controlled clinical trial of BMN 111 in infants and young children with a diagnosis of achondroplasia.
- Trial name
- NCT03583697
- Testing
- BMN 111
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 75 people
- Sponsor
- BioMarin Pharmaceutical
Pneumococcal Infections, Pneumococcal Conjugate Vaccine
A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Infants and Young Children
The purpose of this study is to assess the safety and immunogenicity of 13-valent Pneumococcal conjugate vaccine in Chinese infant and young children.
- Trial name
- NCT03574389
- Testing
- 13vPnC, Hib
- Where
- 2 sites in China
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- Pfizer
Growth Failure, Good Infant and Young Child Feeding Practices
Joint Infant and Young Child Nutrition Program and Malnutrition Prevention
Study title: Joint Infant and young children nutrition program in Burkina Faso: Impact evaluation Hypothesis: The fortification of complementary foods associated with a counseling on feeding practices for infants and young…
- Trial name
- NCT02136966
- Testing
- MNP + IYCN counseling + cooking demonstrations
- Where
- Burkina Faso
- Volunteers
- 2,212 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Trauma
The Effects of the Anesthetic Ketamine in Young Children Undergoing Procedural Sedation
In the emergency department (ED), ketamine is a popular anesthetic agent during sedation of children for painful and other short procedures.
- Trial name
- NCT02650154
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
A Study of the Safety and Efficacy of Tobramycin for Inhalation in Young Children With Cystic Fibrosis
This study's primary goals are to test the safety and effectiveness of Tobramycin for Inhalation (TOBIr) in cystic fibrosis (CF) patients who are between 6 months and 6 years of age.
- Trial name
- NCT00006280
- Testing
- Tobramycin for Inhalation
- Where
- 9 sites in United States
- Volunteers
- 98 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)