Clinical trials: Infantile Hemangiomas
Infantile Hemangioma (IH)
Abrupt Discontinuation Versus Gradual Tapering of Propranolol in Infantile Hemangioma
Infantile hemangioma is the most common benign vascular tumor in infancy. Oral propranolol is the first-line systemic treatment for infantile hemangiomas requiring therapy.
- Trial name
- PROIHSTOP (NCT07665177)
- Testing
- Abrupt Discontinuation of Propranolol, Gradual Tapering of Propranolol
- Where
- China
- Volunteers
- 110 people
- Sponsor
- West China Hospital
Infantile Hemangioma
Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy
There is an unsatisfied medical need for a first-line treatment of proliferating IHs with a good benefit/risk profile. Based on the recent findings of encouraging results obtained with propranolol in a series of infants with…
- Trial name
- NCT01056341
- Testing
- Propranolol
- Where
- 59 sites in United States, Australia and 14 more
- Volunteers
- 512 people
- Sponsor
- Pierre Fabre Dermatology
Hemangioma, Capillary
A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy
Hemangiomas of infancy, the most common benign tumors of infancy, are congenital or early infancy lesions characterized by a rapid postnatal growth, with high expression of angiogenic stimulators for 9-18 months, followed by slow…
- Trial name
- NCT00601016
- Testing
- Imiquimod 5% cream
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- St. Justine's Hospital
Lipoma, Branchial Cleft Anomalies
Radiological Diagnosis of Pediatric Neck Swellings
Various diagnostic imaging modalities have been utilized in the assessment of pediatric neck lesions, including gray-scale and Doppler ultrasonography, conventional and three-dimensional computed tomography (CT), magnetic…
- Conditions
- Lipoma, Branchial Cleft Anomalies, Cystic Hygroma (Macro-cystic Lymphatic Malformation), Rhabdomyosarcoma
- Trial name
- NCT07734805
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Infantile Hemangiomas
Timolol Option for Ulcerated Hemangiomas (TOUCH Trial)
The purpose of this study is to determine whether Timolol 0.5% Gel Forming Solution is safe and effective in promoting wound healing of infantile ulcerated hemangiomas compared with standard conservative management with topical…
- Trial name
- TOUCH (NCT01408056)
- Testing
- Timolol 0.5% Gel Forming Solution (GFS), Mupirocin 2% Ointment
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Healthy Subjects
A Comparative Study of the Pharmacokinetic Profiles of Timolol Maleate Ophthalmic Gel With Timolol Maleate Gel
The goal of this clinical trial is: 1)To evaluate the pharmacokinetic profiles and safety of 0.5% Timolol Maleate Ophthalmic Gel Forming Solution in healthy adult subjects after multiple dosing; 2)To compare the systemic exposure…
- Trial name
- NCT06813807
- Testing
- 0.5% TM
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Auson Pharmaceuticals Inc.
Hemangioma of Infancy
Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
Hemangiomas are relatively common lesions in infants. Most go away spontaneously after one year of life and do not need treatment.
- Trial name
- NCT00967226
- Testing
- propranolol, Prednisolone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Nancy Bauman
Hemangioma
A Prospective Study Comparing the Incidence of Infantile Hemangiomas Following Normal Pregnancies Versus Pregnancies Complicated by Placental Abnormalities
The purpose of this study is to investigate the pathogenesis of hemangiomas of infancy as they relate to normal pregnancies and those pregnancies complicated by placenta abnormalities.
- Trial name
- NCT00490607
- Where
- United States
- Sponsor
- Rady Children's Hospital, San Diego
Infantile Haemangiomas
Systemic Propranolol for the Treatment of Paediatric Patients With Infantile Hemangiomas
This is retrospective study. The patients treated with oral propranolol at a dose of 2.0 mg/kg per day. Growth parameters (height and weight) were measured at the beginning, the end of treatment and 2 years after treatment.
- Trial name
- NCT04651049
- Testing
- propranolol
- Volunteers
- 128 people
- Sponsor
- Qilu Hospital of Shandong University
Hemangiomas
Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy
The purpose of the study is to determine if pulse steroids are more efficacious and safer than the standard treatment with oral corticosteroids.
- Trial name
- NCT00312520
- Testing
- prednisolone, methylprednisolone
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Hemangiomas of Infancy
Hemangioma Growth During the First 6 Months of Life
One of the most important and unique characteristics of infantile hemangiomas is their dramatic growth during early infancy. Most hemangiomas are either absent at birth or barely evident as a small scratch or bruise-like area.
- Trial name
- NCT00911781
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hemangioma
Topical Timolol for Superficial Infantile Hemangioma
Infantile hemangioma (IH) is the most common benign vascular tumor in pediatric population. The characteristic natural history of this tumor is rapid growth in the first year of life and follows by spontaneous involution.
- Trial name
- NCT01685398
- Testing
- 0.5% timolol maleate eye drop, Normal saline
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hemangioma
Off Label Use of Propranolol for Infancy Hemangiomas
Propranolol use for infancy hemangiomas is of world wide interest due to low cost and presumed efficacy. The investigators hypothesized that the drug ist highly active against growing hemangiomas in problematic sites and that…
- Trial name
- PIHS (NCT01211080)
- Testing
- Propranolol
- Where
- 3 sites in Germany
- Volunteers
- 72 people
- Sponsor
- Hannover Medical School
Infantile Hemangioma
Optimizing Timolol Maleate Treatment of Infantile Hemangioma by Doppler Ultrasound Examination
The purpose of this study is to assess the safety and efficacy of Timolol Maleate treatment for different depth of infantile hemangioma based on B-ultrasonography.
- Trial name
- NCT03842631
- Testing
- Timolol Maleate 0.5% Oph Soln
- Where
- China
- Volunteers
- 150 people
- Sponsor
- XiaoXi Lin
Infantile Hemangioma
Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
There is an unsatisfied medical need for a first-line treatment of localized uncomplicated proliferating Infantile Hemangioma with a good benefit/risk profile.
- Trial name
- NCT01512173
- Testing
- propranolol gel
- Where
- 17 sites in France, Poland and 1 more
- Volunteers
- 82 people
- Sponsor
- Pierre Fabre Dermatology
Hemangioma
Randomized Study of Hormonal Regulation of Infantile Hemangioma
OBJECTIVES: I. Evaluate the clinical efficacy of leuprolide, a gonadotropin-releasing hormone agonist (GnRHa), in treating infants with vision-endangering or large, disfiguring hemangiomas. II.
- Trial name
- NCT00004436
- Testing
- leuprolide, prednisone
- Volunteers
- 30 people
- Sponsor
- FDA Office of Orphan Products Development
Infantile Hemangioma
Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas
The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a…
- Trial name
- NCT05479123
- Testing
- Propranolol three times a day, Propranolol twice a day, Timolol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The University of Texas Health Science Center, Houston
Infantile Hemangioma
Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma
Is to compare and evaluate the efficacy of oral captopril with oral propranolol, intralesional propranolol injection, and topical Timolol in the treatment of infantile hemangioma and their effect on vascular endothelial growth…
- Trial name
- NCT04288700
- Testing
- oral propranolol, Oral Captopril, intralesional propranolol injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Infantile Hemangioma
Timolol Maleate Gel for the Treatment of Infantile Hemangioma
The goal of this clinical trial is to evaluate the safety and efficacy of timolol maleate (TM) gel in subjects with superficial infantile hemangioma (IH) in the proliferative phase.
- Trial name
- NCT06677853
- Testing
- Timolol Maleate Gel
- Where
- 8 sites in China
- Volunteers
- 168 people
- Sponsor
- Auson Pharmaceuticals Inc.
Infantile Hemangioma
Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas
Through this study, the investigators shall compare the effectiveness of atenolol with propranolol in the treatment of IH. In addition, the investigators shall try to elucidate the mechanism of action of beta blockers by…
- Trial name
- NCT03237637
- Testing
- oral propranolol, oral atenolol
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh