Clinical trials: Infants
Infant, Newborn, Infant, Low Birth Weight
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
This large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Phenobarbital (NCT00009620)
- Testing
- Phenobarbital, Saline
- Where
- 11 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Feeding and Eating Disorders
The Influence of Upright Feeding Position on Pulmonary and Ear Morbidity
Does upright feeding position of 3 month old infants reduce respiratory and ear morbidity during the following year?
- Trial name
- NCT03247946
- Testing
- upright head position
- Where
- Israel
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Malaria
Safety and Immunogenicity of GSK Biologicals' Malaria Vaccine 257049 When Administered on 7 Schedules to African Infants
The aim of the malaria vaccine program of the MVI/GSK partnership is to develop an efficacious malaria vaccine that is deliverable through the existing system, the Expanded Program on Immunization (EPI) of WHO.
- Trial name
- NCT01231503
- Testing
- GSK Biological's Investigational Malaria Vaccine 257049, Engerix-B, Tritanrix HepB Hib
- Where
- Malawi
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dermatitis
Infant Fecal Insult Study
The rationale for the study is to better understand the dynamics of skin microflora following skin barrier disruption in an adult dermatitis model.
- Trial name
- NCT02979210
- Testing
- Artificial Fecal Insult, Phosphate Buffered Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
- Conditions
- Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
- Trial name
- NCT03059420
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Influenza
Post-Partum Immunization With Live Attenuated Influenza Vaccine (LAIV) or Trivalent Influenza Vaccine (TIV) in Post-Partum Breast Feeding Women
The purpose of this research study is to learn more about the safety of 2 licensed flu vaccines, nasal spray and flu vaccine shot, in mothers and their infants, when given to women who are breastfeeding and to compare the immune…
- Trial name
- NCT01181323
- Testing
- Cold-adapted live attenuated influenza virus vaccine, trivalent, Trivalent inactivated influenza vaccine
- Where
- 6 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Osteopenia Prematurity
Effect of Assisted Exercise on Musculoskeletal System and Growth in Preterm Infants
The primary aim of this study is to assess whether physical activity programs in preterm infants improve bone mineralization as well as growth and reduce the risk of fractures.
- Trial name
- NCT03354988
- Testing
- Physical exercise group, Control group
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infantile Colic
Evaluation of Safety and Efficacy of New Infant Formula in Infantile Colic
The study is conducted to examine the safety and efficacy of a new infant formula and its effects on the gastrointestinal tolerance in infants suffering from colic.
- Trial name
- Coco (NCT01721850)
- Testing
- control formula, intervention formula 1, intervention formula 2
- Where
- 18 sites in Germany, Italy
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Postpartum Depression, Psychoeducation
Psychoeducational Intervention to Reduce Depressive Symptoms and Strengthen Mother-Infant Bonding
The study aims to evaluate the effectiveness of a psychoeducational intervention designed within the framework of the Watson Human Caring Model in reducing postpartum depressive symptoms and creating a stronger mother-infant…
- Conditions
- Postpartum Depression, Psychoeducation, Mother-Infant Interaction
- Trial name
- NCT07062159
- Testing
- the psychoeducation intervention program, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Yasemin Ozhuner
Generation of Reactive Oxygen Species, Intestinal Inflammation
Assessment of Complementary Feeding of Canadian Infants
With the recent recommendation from Health Canada to extend exclusive breast-feeding to 6 months of age there has arisen concern about what is the best solid food to introduce at that time.
- Trial name
- Infant Feeding (NCT01790542)
- Testing
- Iron fortified cereal, Iron fortified cereal with fruit, Meat
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Responses to Infant Immunisations
A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants
Due to an unexpectedly high number of infant deaths from whooping cough in 2012, the Department of Health acted to protect newborns between birth and completion of primary immunisations, the period with greatest risk of disease.
- Trial name
- iMAP2 (NCT02145624)
- Testing
- Repevax, Boostrix-IPV
- Where
- 3 sites in United Kingdom
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Public Health England
Depression
Antidepressant Use During Pregnancy
This study will determine the safety of antidepressant use during pregnancy for both the mother and the child.
- Trial name
- NCT00279370
- Where
- United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Rotavirus Gastroenteritis
Safety, Reactogenicity and Immunogenicity of Heat-stable Rotavirus Vaccine (HSRV) in Adults and Infants
Rotaviruses are the leading cause of severe, dehydrating diarrhoea and related deaths in children aged less than 5 years worldwide and are reported to infect nearly every child by the age of 5 years.
- Trial name
- HSRV (NCT02728869)
- Testing
- Heat Stable Rotavirus (HSRV) Vaccine, RotaTeq®
- Where
- Bangladesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MSD Wellcome Trust Hilleman Laboratories Pvt. Ltd.
Other Preterm Infants
Invictus Medical, Medical Cranial Support Device (CSD) is a Device Safety Study in Infants at Risk of Head Ulcers.
While using the device as a cushion, the passive distribution of pressure over bony skull prominences of infants will protect against formation of pressure ulcers.
- Trial name
- INV-CS-001 (NCT02224859)
- Testing
- HCP will place the Invictus Cranial Support Device (CSD) on the patient, human intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Invictus Medical, Inc.
Overweight and Obesity, Allergy
Effects of Vaginal Seeding on Infants' Body Mass Index and Allergy Risk for Caesarean-delivered Children
This is a single-blind randomized controlled trial, aiming to evaluate the effects of vaginal seeding on body mass index as well as allergy risk for cesarean-delivered infants.
- Trial name
- NCT03809390
- Testing
- Vaginal seeding
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Peking University
RSV Infection
Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine, LID/ΔM2-2/1030s, in RSV-Seronegative Infants and Children 6 to 24 Months of Age
The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of a single dose of a recombinant, live-attenuated respiratory syncytial virus (RSV) vaccine, LID/ΔM2-2/1030s, in RSV-seronegative infants and…
- Trial name
- NCT04520659
- Testing
- RSV LID/ΔM2-2/1030s
- Where
- 3 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cystic Fibrosis
Safety and Efficacy of Inhaled OligoG CF-5/20 for the Treatment Cystic Fibrosis
Cystic fibrosis (CF) is a disease caused by a mutation in the gene that makes the cystic fibrosis transmembrane regulator protein.
- Trial name
- NCT00970346
- Testing
- OligoG CF-5/20
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AlgiPharma AS
Neonatal Acute Kidney Injury, Childhood Chronic Kidney Disease
Follow-up of AKI in Neonates During Childhood Years
The purpose of this study is to learn more about how to identify signs of early chronic kidney diseases in children who were born prematurely with low birth weight (less than 3 ½ pounds).
- Trial name
- FANCY (NCT02306642)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Matthew Harer, MD
Lactation Disorder With Baby Delivered, Nutrition Disorder, Infant
Macronutrients in Lactating NICU Parents - Impact of Kangaroo Care
The goal of this clinical trial is to learn about the impact of Kangaroo Care (holding your baby skin-to-skin on your chest) in lactating parents with babies in the Neonatal Intensive Care Unit (NICU) that cannot directly…
- Trial name
- MILK (NCT06047470)
- Testing
- Kangaroo Care, No Kangaroo Care
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Complementary Feeding, Infant
Outcome of Different Complementary Feeding Methods in First Year of Life of Infants
This randomized controlled trial aimed to compare adherence to two complementary feeding methods-Baby-Led Introduction to SolidS (BLISS) and Parent-Led Weaning (PLW)-in infants aged 6-12 months.
- Trial name
- Complementary (NCT07467876)
- Testing
- Baby-Led Introduction to SolidS (BLISS), Parent-Led Weaning (PLW)
- Where
- Pakistan
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma