Clinical trials: Infants
Heart Defects, Congenital
CTICU Pacifier Activated Music Player and Mother's Voice
The purpose of this study is to determine if intensive training of Non-Nutritive Suck (NNS) using contingent positive reinforcement with mother's voice can improve the feeding outcomes of infants with congenital heart defect…
- Trial name
- NCT03035552
- Testing
- Pacifier activated music player
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Nationwide Children's Hospital
Infections, Rotavirus
Study to Assess the Efficacy, Immunogenicity and Safety of Liquid Human Rotavirus Vaccine, in Healthy Chinese Infants
The purpose of this study is to assess the efficacy, immunogenicity and safety of GSK Biologicals' liquid human rotavirus vaccine in healthy Chinese infants 6 to 16 weeks of age.
- Trial name
- NCT01171963
- Testing
- GSK Biologicals' liquid human rotavirus vaccine 444563, Infanrix™, Institute of Medical Biology Chinese Academy of Medical Sciences' Oral poliovirus vaccine (OPV)
- Where
- 4 sites in China
- Volunteers
- 3,340 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cystic Fibrosis
PEP and OPEP Devices in Cystic Fibrosis
Cystic fibrosis (CF) is the most common severe autosomal recessive genetic disease in Caucasians. The CFTR (cystic fibrosis transmembrane regulator) gene, which encodes the chloride channel of the epithelial cell membrane, is…
- Trial name
- NCT05801952
- Testing
- Aerobika* OPEP, PARI O-PEP (Flutter), PARI PEP® S System
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Bronchiolitis
Bilevel Noninvasive Ventilation in Infants With Bronchiolitis Presenting With Apnea
This physiological study aims to compare Bilevel Positive Airway Pressure and continuons positive airway pressure in infants with severe bronchiolitis presenting with apnea
- Trial name
- NCT04408534
- Testing
- mode of noninvasive ventilation
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Necrotizing Enterocolitis, Premature Birth
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
- Trial name
- CortECS (NCT04972734)
- Testing
- premature newborns developing a NEC, premature newborns without NEC
- Where
- France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bronchopulmonary Dysplasia
Ultrasound Assessment of Diaphragmatic Function in Infants With BPD
Preterm infants have high and prolonged exposure to positive pressure ventilation, which contributes to acute lung injury and the development of bronchopulmonary dysplasia (BPD).
- Trial name
- NCT04941963
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Mother Infant Contact
The Effect of Mother-Infant Contact Barrier on Maternal Sadness and Adaptation
This study was conducted to investigate the effect of mother-infant contact deprivation on maternal sadness and maternal adaptation. The research is a randomized controlled experimental study.
- Trial name
- NCT06688604
- Testing
- skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Cystic Fibrosis
Continuous Azithromycin in Cystic Fibrosis Patients Beyond Two Years
Azithromycin is an antibiotic currently prescribed continuously in cystic fibrosis patients. It was shown that this treatment taken every day or every week for 12 months, can improve the respiratory state of patients.
- Trial name
- AZITHRO (NCT02803944)
- Testing
- Azithromycin
- Where
- France
- Volunteers
- 2,055 people
- Sponsor
- Hospices Civils de Lyon
HIV
Point of Care Early Infant Diagnosis Patient Impact Study
In Malawi, early infant HIV diagnosis (EID, i.e. HIV screening of infants under 18 months of age) is conducted using molecular diagnostics at central laboratories.
- Trial name
- NCT02744404
- Testing
- POC EID
- Where
- 7 sites in Malawi
- Volunteers
- 1,752 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Primary Immunodeficiency, DOCK8
Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
Background: National Institutes of Health (NIH) researchers have been studying immune cells (white blood cells) to better understand how the human body s defense system works and adjusts or regulates itself, and how changes in…
- Conditions
- Primary Immunodeficiency, DOCK8, Virus Susceptibility
- Trial name
- NCT00895271
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tolerance
Safety of Lactobacillus Fermentum in Newborn Infants
In the last years manipulation of intestinal microbiota with probiotics has gained an increasing interest, specially in infant nutrition since recent studies has demonstrated the presence of probiotics in human milk.
- Trial name
- NCT01346644
- Testing
- Infant formula
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Puleva Biotech
Mild Birth Asphyxia, Moderate Birth Asphyxia
Olfactory Testing in Perinatal Asphyxia: Enhancing Risk Assessment
Neonatal asphyxia remains a leading cause of neurodevelopmental disabilities despite advancements in perinatal care. Hypoxic-ischemic encephalopathy (HIE), a severe outcome of asphyxia, impacts 1-3 infants per 1,000 live births…
- Trial name
- MEMOBRAIN (NCT06744244)
- Testing
- Olfactory Testing, Heart rate (HR), Heart Rate Variability (HRV), Respiratory Rate (RR), peripheral oxygen saturation (SpO2), Video-EEG
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Parma
Muscular Atrophy, Spinal
A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy
This study will evaluate the pharmacokinetics (PK) and safety of risdiplam in participants with spinal muscular atrophy (SMA) under 20 days of age at first dose.
- Trial name
- PUPFISH (NCT05808764)
- Testing
- Risdiplam
- Where
- 13 sites in United States, Belgium and 6 more
- Volunteers
- 11 people
- Sponsor
- Hoffmann-La Roche
Prematurity, Vaccination
Babies Born Early Antibody Response to Men B Vaccination: BEAR Men B
In the UK, babies receive their vaccinations according to a standard schedule, irrespective of their gestation at birth. This policy is designed so that all babies are protected as early as possible from vaccine preventable…
- Conditions
- Prematurity, Vaccination, Meningococcal Disease
- Trial name
- BEAR Men B (NCT03125616)
- Testing
- 4CMenB Vaccine
- Where
- United Kingdom
- Volunteers
- 136 people
- Sponsor
- St George's, University of London
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Preterm Intraventricular Hemorrhage
The Relationship Between Superior Vena Cava Flow and Intraventricular Hemorrhage in Preterm Infants
The aim of the study was to evaluate the relationship between superior vena cava (SVC) flow measurements within the first 24 hours of life and development of intraventricular hemorrhage in preterm born infants.
- Trial name
- NCT05050032
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Marwa Mohamed Farag
Premature Infant, Mothers
Efficacy of Expressive Writing in Mothers of Preterm Infants
Premature birth can lead the mother to lose control of herself, and be a contributor to the psychological stress experienced due to the sudden breakdown of the interaction with her infant because of hospitalization in a neonatal…
- Trial name
- NCT03423914
- Testing
- Expressive writing, Only Writing
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad Industrial de Santander
Pneumococcal Disease
A Study to Learn About the Safety of PREVENAR 20 Vaccine in Infants Aged Between Two to Six Months
The purpose of this study is to learn about the safety of 20-valent Pneumococcal Conjugate Vaccine (PREVENAR 20) under actual clinical practice in Japan.
- Trial name
- NCT06622109
- Testing
- 20-valent Pneumococcal Conjugate Vaccine
- Where
- Japan
- Volunteers
- 1,100 people
- Sponsor
- Pfizer
Prader-Willi Syndrome
Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants.
The objective of this study is to collect data on tolerance and effects of early treatment with oxytocin in children with Prader Willi Syndrome aged from 3 to 4 years and to compare these infants with not treated age-matched…
- Trial name
- OT2SUITE (NCT03081832)
- Testing
- Oxytocin, Control
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Toulouse
Self Efficacy, Breast Feeding
Development of 'My Breastfeeding Guide' Mobile Nursing Application
The research was planned to develop the "My Breastfeeding Guide" mobile nursing application, which was developed based on Dennis' Breastfeeding Self-Efficacy Theory and Pender's Health Promotion Model, and to determine its effect…
- Conditions
- Self Efficacy, Breast Feeding, Attachment
- Trial name
- Nursing (NCT05901298)
- Testing
- My Breastfeeding Guide
- Where
- Cyprus
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University