Clinical trials: Infarction, active
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Left Ventricular Thrombus, Myocardial Infarction
Anticoagulation in Post MI LV Thrombus Trial in Nepal
Introduction: The prevalence of left ventricular(LV) thrombus after acute myocardial infarction has decreased with thrombolysis and primary angioplasty intervention worldwide.
- Trial name
- WaRMIN (NCT05794399)
- Testing
- Rivaroxaban, Warfarin
- Where
- Nepal
- Volunteers
- 196 people
- Sponsor
- Shahid Gangalal National Heart Centre
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Acute Myocardial Infarction (AMI)
Safety and Efficacy of MiSaver (CB Cells) for Acute Myocardial Infarction, Phase II
This trial is a Phase II, multicenter clinical study. The purpose of this trial is to evaluate the safety and efficacy of MiSaver, a cellular therapy product, in patients who have experienced an acute myocardial infarction (AMI).
- Trial name
- SEMIAMI (NCT07134712)
- Testing
- Cord Blood Nucleated cells
- Where
- 4 sites in Australia, Taiwan
- Volunteers
- 102 people
- Sponsor
- HONYA Medical Co Ltd
Myocardial Injury After Noncardiac Surgery (MINS), Myocardial Ischemia
Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)
This study is a multicentre, randomized controlled trial of ivabradine versus placebo.
- Trial name
- PREVENT-MINS (NCT05279651)
- Testing
- Ivabradine
- Where
- 26 sites in Poland
- Volunteers
- 2,146 people
- Sponsor
- Jagiellonian University
Acute Coronary Syndromes
Impact of Non-medicalized ECG Practices Initiated by SAMU in Dispatch Strategies
The performance of an ECG by non-medicalized prehospital teams (firefighters, first responders, paramedic ambulances) is developing across the territory to cope with the increasing demand (SAMU calls) for a service that cannot…
- Trial name
- ECG-PHNM (NCT07144059)
- Testing
- ECG by the SMUR after medical interrogation by the SAMU, ECG performed by a non-medical vector
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Sud Francilien
ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices
Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI
1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices. 2. To assess the association between repolarization indices among early, late presentation in relation to…
- Conditions
- ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices, Total Ischemic Time, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07175259
- Testing
- Echocardiography
- Volunteers
- 500 people
- Sponsor
- Assiut University
Acute Myocardial Infarction (AMI)
the Impact of Transcutaneous Vagus Nerve Stimulation on Cardiovascular Events in Patients With Acute Myocardial Infarction
The acute mortality rate of acute myocardial infarction (AMI) reduced significantly due to emergency reperfusion and subsequent treatment strategies. However, it remains a major cause of disability and death globally.
- Trial name
- NCT06991283
- Testing
- transcutaneous vagus nerve stimulation
- Volunteers
- 278 people
- Sponsor
- Shanghai East Hospital
STEMI - ST Elevation Myocardial Infarction
Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI
This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (>60 min after admission in PCI-center)…
- Trial name
- RAPID-STEMI (NCT07641231)
- Testing
- Single, weight-adjusted i.v. bolus of tenecteplase, catheterisation
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Ischaemic Cerebral Infarction
Cerebral Safety After Pulsed-Field Ablation of Atrial Fibrillation
A study evaluating the incidence of ischaemic lesions detected by brain MRI scan in subjects undergoing pulsed-field ablation for atrial fibrillation (VARIPULSE system).
- Trial name
- NCT06786988
- Testing
- MRI
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Sudden Cardiac Death, Myocardial Infarction
Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction
TWIN-SCD STEMI is a multicentric prospective, non-randomized pilot study designed to establish a multiparametric model for predicting life-threatening ventricular arrhythmias in patients experiencing their first myocardial…
- Trial name
- TWIN-SCD STEMI (NCT07527494)
- Testing
- Programmed ventricular stimulation, Cardiac CT scan
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bordeaux
Major Cardiovascular Event, Established Atherosclerotic Cardiovascular Disease
A Study Assessing Repatha® in Combination With Standard of Care (SOC) Compared With SOC on Major Cardiovascular Events in Chinese Participants With Atherosclerotic Cardiovascular Disease
The primary objective of the study is to evaluate real-world effectiveness of treatment with Repatha® in combination with SOC, compared with SOC alone, on the risk for cardiovascular (CV) death, myocardial infarction (MI)…
- Trial name
- NCT06295679
- Where
- 90 sites in China
- Volunteers
- 7,000 people
- Sponsor
- Amgen
Cardiogenic Shock
Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA)
This is a prospective and retrospective multicentre study conducted under the scientific coordination of the IRCCS Fondazione Don Gnocchi and funded by the Italian Ministry of Health (PNRR-MCNT2-2023-12377767).
- Trial name
- ENIGMA (NCT06572826)
- Testing
- Cardiac Rehabilitation intervention
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Acute Myocardial Infarction, Insomina
Impact of New-onset Insomnia After Coronary Revascularization for Patients With Acute Myocardial Infarction
The present study aimed to evaluate the impact of acute insomnia on long-term clinical outcomes in patients underwent PCI or CABG for AMI using the Korean National Health Insurance Service (NHIS) database, and to identify the…
- Trial name
- MI-INSOMINA (NCT07416617)
- Testing
- Insomnia medication, No insomnia medication
- Where
- South Korea
- Volunteers
- 235,342 people
- Sponsor
- Samsung Medical Center
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Myocardial Infarction
Percutaneous Coronary Intervention for Myocardial Infarction at Fujian Provincial Hospital
Research Objectives: This clinical trial aims to evaluate the efficacy and safety of percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI).
- Trial name
- Fu-AMI (NCT07405788)
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 1,344 people, healthy volunteers welcome
- Sponsor
- Kaiyang Lin
Hemodynamic Parameters, Fatigue
Effect of Isometric Exercise Versus Hand Reflexology on Hemodynamic Parameters Among Patients With AMI
The goal of this clinical trial is to evaluate the comparative effect of isometric exercise versus hand reflexology on primary hemodynamic parameters, fatigue, and anxiety in patients with acute myocardial infarction.
- Conditions
- Hemodynamic Parameters, Fatigue, Anxiety
- Trial name
- NCT07109960
- Testing
- Isometric exercise and hand reflexology
- Where
- Iraq
- Volunteers
- 136 people
- Sponsor
- University of Baghdad
Type 2 Diabetes Mellitus Myocardial Infarction
Ertugliflozin's Effect on Heart Function in Diabetic Patients After Myocardial Infarction
This prospective, randomized, open-label, blinded endpoint (PROBE) trial evaluates the efficacy of early ertugliflozin initiation (10 mg daily) compared to standard care alone on cardiac function in 476 adult patients with type 2…
- Trial name
- NCT07621380
- Testing
- Ertugliflozin 10 mg, Standard AMI Care
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Shanghai Zhongshan Hospital