Clinical trials: Infected Wound
Cruciate Ligament Reconstruction Infection, Septic Arthritis
A Metagenomic Next-generation Sequencing (mNGS)-Guided Sequential Culture Strategy for Postoperative Cruciate Ligament Reconstruction Infection (CLRI): a Retrospective Cohort Study
This retrospective cohort study evaluates a sequential diagnostic strategy for patients with postoperative cruciate ligament reconstruction infection (CLRI).
- Conditions
- Cruciate Ligament Reconstruction Infection, Septic Arthritis, Surgical Wound Infection, Joint Infection
- Trial name
- NCT07852598
- Testing
- Metagenomic next-generation sequencing (mNGS), mNGS-guided modified culture, Conventional microbiological culture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Surgical Wound, Wound Dehiscence, Surgical
Prophylactic Negative Pressure Wound Therapy for High Risk Laparotomy Wounds. A Randomized Prospective Clinical Trial.
Negative pressure wound closure technique (NPWT) has been widely introduced in different clinical settings. Most of the studies report it as an effective and cost-effective method to treat complicated surgical wounds or even open…
- Conditions
- Surgical Wound, Wound Dehiscence, Surgical, Surgical Site Infection, Dehiscence of Internal Surgical Wound
- Trial name
- NCT03716687
- Testing
- Prophylactic negative pressure wound dressing after laparotomy
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- St. Borbala Hospital
Bariatric Surgery Candidate
The Effect of the Care Bundle to be Applied to Obesity Surgery Patients on Surgical Site Infection and Patient Comfort
One of the most effective treatment methods of obesity is surgery. Bariatric surgery is classified as a clean-contaminated wound. The expected benefit from surgery is weight loss.
- Trial name
- NCT05930639
- Testing
- Surgical Site Infection (SSI) prevention package
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Malatya Turgut Ozal University
Colorectal Surgery, Wound Infections
REDWIL: Reduction of Wound Infections in Laparoscopic Colon Resections by Wound Protectors
Surgical site infection is common in colorectal surgery leading to increased postoperative pain, longer hospital stay, delayed wound healing and increased re-operation rates.
- Trial name
- REDWIL (NCT01049971)
- Testing
- wound protector, no wound protector
- Where
- Germany
- Volunteers
- 109 people
- Sponsor
- Charite University, Berlin, Germany
Surgical Wound Infection, Wound; Abdomen, Abdominal Wall
Surgical Site Infection Rate After Intra-Abdominal Surgery Using Negative Pressure Wound Therapy at Initial Closure
The goal of this study is to present a large single-institution experience reporting surgical site infection rates in patients who have undergone intra-abdominal surgery followed by wound closure with Negative Pressure Wound…
- Conditions
- Surgical Wound Infection, Wound; Abdomen, Abdominal Wall, Surgery
- Trial name
- NCT01924884
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Post-Sternotomy Deep Sternal Wound Infection
Vancomycin and Negative Pressure Therapy for Post-sternotomy Deep Sternal Wound Infection
Only a limited number of studies have been published that monitored the penetration of antibiotics from blood into exudate in patients treated with negative pressure wound therapy (NPWT), and that evaluated the adequacy of…
- Trial name
- NCT06506032
- Testing
- Intravenous Vancomycin administration, Standard postoperative therapy
- Where
- 5 sites in Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Ostrava
Surgical Site Infection
Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery
Intrabdominal antibiotic irrigation will reduce wound and intrabdominal infection.
- Trial name
- lavage (NCT01378832)
- Testing
- Intra-peritoneal antibiotic lavage
- Volunteers
- 102 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Surgical Wound, Post Operative Wound Infection
Early Versus Delayed Bathing of Orthopaedic Surgical Wounds
This is a single center randomized control trial assessing the effect of early versus delayed bathing on orthopaedic surgical wounds in patients undergoing surgical treatment of fractures.
- Trial name
- EVDB (NCT06014411)
- Testing
- Time to bathing (delayed), Time to bathing (early)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Hospital for Special Surgery, New York
Wound Infection
Comparative Study Between Subcutaneous Tissue Closure Versus Drain in Obese Women Undergo Elective Cesarean Section
Randomised cinical trial in Kasr Alainy Hospital.352 obese women pregnant with gestational age >38 wk ,theire age range from (25-35) years and BMI between (30 -40) undergoing elective cesarean section were randomised into 4…
- Trial name
- NCT04177381
- Testing
- Cesarean section, subcutanous sutures, subcutanous drain
- Where
- Egypt
- Volunteers
- 352 people
- Sponsor
- Cairo University
Surgical Site Infections
Effect of Cefazolin and Normal Saline Irrigation on Surgical Site Infections (SSIs)
This study conducted to assess the effects of normal saline or cefazolin irrigation on the incidence of SSIs. Hypothesis: Normal saline or cefazolin irrigation decreases the incidence of SSIs.
- Trial name
- NCT01566734
- Testing
- Cefazolin irrigation, Normal Saline Irrigation
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Hormozgan University of Medical Sciences
Infection Wound, Antibiotic Resistant Infection
The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy
Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.
- Trial name
- NCT06607887
- Testing
- IV antibiotic, Oral antibiotic
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Minia University Hospital
Colorectal Cancer, Lung Cancer
The Effects of Preoperative Bevacizumab on Perioperative Complications
This is a nationwide multicenter,retrospective,observational real-world study. 1. To assess the risk of perioperative complications in patients with tumor who received bevacizumab prior to unexpected operation. 2.
- Conditions
- Colorectal Cancer, Lung Cancer, Operation Wound; Infection, Bevacizumab
- Trial name
- NCT04788381
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Supracondylar Humerus Fracture, Post Operative Wound Infection
Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)
The aim of this study is to determine if antibiotics affect the outcome after percutaneous surgery for pediatric supracondylar humerus fractures.
- Trial name
- NCT03261830
- Testing
- Cefazolin, Clindamycin, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Sumit Gupta
Postpartum Complication
IMPACT: Improving Maternal Postpartum Access to Care Through Telemedicine
The purpose of this study is to compare two complex, multi-component evidence-based postpartum interventions in underserved populations of lower socioeconomic status in an effort to reduce maternal morbidity and mortality.
- Trial name
- IMPACT (NCT06218355)
- Testing
- Intensive Education, Enhanced Virtual Care
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes, Wound Infection
Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of tedizolid (Sivextro, Merck \& Co.), a novel oxazolidinone antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic patients with lower limb wound…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620787
- Testing
- Tedizolid, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Surgical Site Infection, Staphylococcus Aureus Infection
Clinical Trial to Demonstrate the Safety and Efficacy of DUOFAG®
DUOFAG® is a phage cocktail containing bacteriophages active against Staphylococcus aureus and Pseudomonas aeruginosa. It is an investigational medicinal product for the treatment of surgical site infections caused by S.
- Conditions
- Surgical Site Infection, Staphylococcus Aureus Infection, Pseudomonas Aeruginosa Infection, Bacterial Infections
- Trial name
- NCT06319235
- Testing
- IMP
- Where
- Czechia
- Volunteers
- 52 people
- Sponsor
- MB PHARMA s.r.o.
Combat Related Symptoms, Combat Trauma
DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma
Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and…
- Conditions
- Combat Related Symptoms, Combat Trauma, Infection, Infection Complication
- Trial name
- DRONE-WOUND (NCT07706608)
- Where
- Ukraine
- Volunteers
- 500 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Lower Limb Ischaemia, Aneurysm
Bacterial Growth in Vascular Surgery Wounds
The amount and species of bacteria have been shown to have an effect in wound infections in several fields of surgery (such as gastrointestinal and orthopaedic surgery and the surgery of facial area).
- Trial name
- NCT01505738
- Testing
- bacterial samples
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- North Karelia Central Hospital
Incisional Hernia, Surgical Wound Infection
Prophylactic Negative Pressure Wound Therapy for Patients Undergoing Incisional Hernia Repair
The study will examine the effect of using Negative Pressure Wound Therapy (NPWT) compared with standard wound dressing among patients undergoing elective open surgery for incisional hernia.
- Conditions
- Incisional Hernia, Surgical Wound Infection, Surgical Site Infection, Quality of Life
- Trial name
- PROPRESS (NCT05050786)
- Testing
- Negative Wound Pressure Therapy (Prevena(TM)), Standard Wound Dressing
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Kristian Kiim Jensen
Deep Sternal Infection, Diabete Mellitus
The Role of Inflammatory Biomarkers in Preventing Deep Sternal Wound Infections After Sternotomy
The goal of this observational study is to reveal blood biomarkers that will have prognostic significance in terms of the development of deep wound infection following sternotomy.
- Conditions
- Deep Sternal Infection, Diabete Mellitus, Mediastinitis
- Trial name
- NCT07376070
- Where
- 2 sites in Georgia
- Volunteers
- 30 people
- Sponsor
- Levan Nebieridze
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