Clinical trials: Infection, Surgical Site
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Surgical Wound Infection
Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures
This is a prospective, randomized, controlled, double-blinded clinical feasibility study of subjects that are being treated for Gustilo and Anderson Type II or IIIA or IIIB Tibial Fractures
- Trial name
- NCT04906642
- Testing
- Next Science, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Next Science TM
Surgical Site Infection
Subcutaneous Lavage in Cesarean Section
The goal of this clinical trial is to learn if antiseptic washing prior to skin closure during cesarean section reduces rates of surgical site infection.
- Trial name
- NCT06454227
- Testing
- Subcutaneous washing, no subcutaneous washing
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Head and Neck Cancer, Covid19
Impact of Covid-19 Pandemic on Management of Head and Neck Cancers
Since its emergence in late December 2019, the SARS-CoV-2 coronavirus has spread rapidly, causing a global health crisis. The disease caused by this highly contagious respiratory virus is called COVID-19.
- Conditions
- Head and Neck Cancer, Covid19, Patient Care
- Trial name
- VADS-Covid (NCT04704466)
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgical Site Infection Prevention, Nursing Education
Effectiveness of Digital Game-Based Learning in Teaching Surgical Site Infection Prevention to Nursing Students
This study aims to evaluate the effectiveness of digital game-based learning in teaching evidence-based surgical site infection prevention interventions to second-year nursing students.
- Trial name
- PreSSI-DGBL (NCT07423702)
- Testing
- Digital Game-Based Learning, Traditional Theoretical Education
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- hatice akaltun
Cava-pulmonary Anastomosis
Surgical Site Infection Study
The purpose of this study is to investigate the pharmacokinetics of cefazolin using both plasma and microdialysate sampling methods in children with single ventricle physiology undergoing their second palliation procedure.
- Trial name
- SSI (NCT01449669)
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Philadelphia
Surgical Site Infections
Prevention of Infections in Cardiac Surgery (PICS) Prevena Study
This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single…
- Trial name
- PICS-Prevena (NCT03402945)
- Testing
- Prevena, Cefazolin, Vancomycin
- Where
- 2 sites in Canada
- Volunteers
- 4,107 people
- Sponsor
- Population Health Research Institute
Surgical Wound Infection
Determining the Worldwide Epidemiology of Surgical Site Infections After Gastrointestinal Surgery
Surgical site infection (SSI) is the most common complication following major gastrointestinal surgery, affecting between 25-40% of patients.
- Trial name
- GlobalSurg 2 (NCT02662231)
- Testing
- Emergency, or elective gastrointestinal resection
- Where
- 2 sites in United Kingdom
- Volunteers
- 12,539 people
- Sponsor
- University of Edinburgh
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Nutrition Related Neoplasm/Cancer, Colorectal Cancer
Postoperative Diet With Hyperproteic Supplement Versus a Supplement With Imunonutrients, in Colorectal Cancer Surgery
The study is a randomized, multicentric, double-blind, controlled with active comparator, parallel groups trial, to demonstrate the non-inferiority in efficacy and therapeutic safety of the postoperative diet with…
- Conditions
- Nutrition Related Neoplasm/Cancer, Colorectal Cancer, Surgery--Complications, Site Infection
- Trial name
- NUTRICOLON (NCT04059731)
- Testing
- Nutrition supplement
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Hospital General Universitario Reina Sofía de Murcia
Appendicitis
A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy.
LESS laparoscopic appendectomy is associated with less pain than conventional 3-port laparoscopic appendectomy.
- Trial name
- NCT01203566
- Testing
- LESS appendectomy, Conventional 3-port laparoscopic appendectomy
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Breast Neoplasms, Breast-Conserving Surgery
Antibiotic Prophylaxis in Oncological Surgery of Breast
Breast cancer is the most frequent malignancy in the female population Brazilian, except non-melanoma skin tumors. Surgery plays an important role in regional spot disease control and the definition of parameters for the adjuvant…
- Conditions
- Breast Neoplasms, Breast-Conserving Surgery, Wound Infection, Antibiotic Prophylaxis
- Trial name
- NCT02809729
- Testing
- Cefazolin, sterile saline, oncologic breast surgery
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- Fabiola Soares Moreira Campos
Surgical Site Infection
Prophylactic Effects for Preventing Surgical Site Infection in Third Molar Surgery
The purpose of this study is to determine the incidence of surgical site infection (SSIs) after third molar surgery for different duration of intravenous ampicillin administration.
- Trial name
- NCT06368102
- Testing
- Ampicillin
- Where
- Japan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Uji Takeda Hospital
Surgical Site Infection, Surgical Wound Infection
ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
ROSSINI 2 is a phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor), multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of several in-theatre…
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Surgery--Complications, Surgery
- Trial name
- ROSSINI 2 (NCT03838575)
- Testing
- 2% alcoholic chlorhexidine skin prep (SKIN PREP), Iodophor Antimicrobial Incise Drapes (DRAPE), Gentamicin-impregnated implants/ sponges (SPONGE)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,610 people
- Sponsor
- University of Birmingham
Bacterial Infections
Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.
- Trial name
- NCT00423657
- Testing
- ceftaroline, vancomycin plus aztreonam
- Where
- 54 sites in United States, Argentina and 10 more
- Volunteers
- 680 people
- Sponsor
- Forest Laboratories
Peritonitis, Postoperative Complications
Intravenous Immunoglobulin in Combination Therapy With Antibacterial Agents for SSI of the Lower Digestive Tract
The purpose of this study is to assess the clinical usefulness of IVIG in combination therapy with antibacterial agents for severe peritonitis after lower digestive tract surgery.
- Trial name
- NCT00511212
- Testing
- intravenous immunoglobulin
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group
Surgical Infection, Cesarean Section Wound
Evaluation of Surgical Site Infection After Cesarean Section
This study aims to investigate surgical site monitoring after cesarean section using a mobile application currently being developed.
- Trial name
- NCT07205939
- Testing
- Mobile Application usage
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Sibel Bulut Haklı
Open Fracture, Trauma
Powdered Intrawound Vancomycin in Open Fractures Trial
The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical…
- Conditions
- Open Fracture, Trauma, Infection, Surgical Site, Fractures, Open
- Trial name
- PIVOT (NCT06504992)
- Testing
- Vancomycin 1000 MG
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- University of Manitoba
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Complications; Cesarean Section, Surgical Wound Infection
Subcuticular Suture for Cesarean Skin Incision Closure
A comparison of the type of suture used for cesarean skin incision approximation and the subsequent rate of wound complications has not been widely studied.
- Trial name
- NCT02459093
- Testing
- poliglecaprone 25 suture, polyglactin 910 suture
- Where
- 2 sites in United States
- Volunteers
- 550 people
- Sponsor
- Montefiore Medical Center