Clinical trials: Infection, Surgical Site
Surgical Site Infection, Surgical Wound Infection
Antibacterial-coated Sutures at Time of Cesarean
Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections after a number of surgical procedures, but none of the previous trials included cesarean delivery.
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Cesarean Section; Infection, Cesarean Section Complications
- Trial name
- ASTC (NCT03386240)
- Testing
- Vicryl-plus, monocryl-plus, PDS-plus (Triclosan-coated Sutures), Vicryl, monocryl, PDS (not coated with triclosan)
- Where
- United States
- Volunteers
- 1,169 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Surgical Site Infection, Brain Tumor
Infection Prevention Bundle in Brain Tumor Surgery
This study aimed to evaluate the effectiveness of an infection prevention bundle on surgical site infections in patients undergone brain tumor surgery.
- Trial name
- NCT04285697
- Testing
- infection prevention bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Surgical Site Infection, Colon Surgery
Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery
The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery.
- Conditions
- Surgical Site Infection, Colon Surgery, Surgical Site Infections
- Trial name
- NeoRiDe (NCT07180615)
- Testing
- Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate
- Where
- 4 sites in Switzerland
- Volunteers
- 458 people
- Sponsor
- Universität Luzern
Bacterial Infections
Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.
- Trial name
- cSSSI (NCT00424190)
- Testing
- IV Vancomycin plus IV Aztreonam, Ceftaroline
- Where
- 52 sites in United States, Argentina and 9 more
- Volunteers
- 698 people
- Sponsor
- Forest Laboratories
Surgical Site Infection
Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion
Surgical site infections (SSI) after spine surgery may occur in up to 12% of cases and can lead to increased morbidity, and healthcare costs In this randomized controlled trial the investigators aim to prospectively investigate…
- Trial name
- VANCO (NCT04017468)
- Testing
- Vancomycin
- Where
- 7 sites in Switzerland
- Volunteers
- 450 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hernia, Ventral Hernia
Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios
This prospective, single-arm clinical study evaluates the safety, feasibility, and early clinical outcomes of High-Purity Type I Collagen (HPTC; Surgicoll-Mesh®) when used as a biologic reinforcement in selected hernia repair…
- Conditions
- Hernia, Ventral Hernia, Incisional Hernia, İnguinal Hernia
- Trial name
- NCT07360691
- Testing
- High-Purity Type I Collagen Mesh
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Infection, Surgical Site
Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial
The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short…
- Trial name
- PICS (NCT06567808)
- Testing
- Cefazolin, Vancomycin
- Volunteers
- 38,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
Surgical Site Infection
Effect of Triclosan-coated Suture on Superficial SSI
The abdominal closure with triclosan coated suture will reduce superficial surgical site infection.
- Trial name
- NCT02018289
- Testing
- Triclosan coated suture, No triclosan
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital General Universitario Elche
Surgical Site Infection
Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections.
- Trial name
- NCT03845790
- Testing
- Blood and microdialysis samples
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Amputation Wound, Amputation Stump Complication
RCT on NPWT for Incisions Following Major Lower-limb Amputation to Reduce Surgical Site Infection
Surgical site infections following lower extremity amputations have been reported in up to 40% of patients. Surgical site infections have significant morbidity and even mortality in terms of emergency room visits, length of…
- Conditions
- Amputation Wound, Amputation Stump Complication, Amputation Stump; Infection, Infection
- Trial name
- NCT03144726
- Testing
- Negative pressure wound therapy, Standard dressing
- Volunteers
- 290 people
- Sponsor
- London Health Sciences Centre
Staphylococcus Aureus, Orthopaedic Surgery
Preoperative Decolonization and Surgical Site Infections in Orthopaedic Surgery - 2 Year Outcome in Prosthetic Surgery
Surgical site infections in orthopaedic surgery are a major problem. Decolonization has been suggested to reduce infection rates.
- Conditions
- Staphylococcus Aureus, Orthopaedic Surgery, Surgical Site Infection, Prevention
- Trial name
- DECO-SSI (NCT03962907)
- Testing
- Chlorhexidine, Lifo-Scrub sol 4%®, 500ml, B. Braun, BACTROBAN® Nasal ong
- Where
- Switzerland
- Volunteers
- 1,318 people
- Sponsor
- Lindenhofgruppe AG
Orthopedic Disorder, Incision Infection
Study on the Preventive Effect of Establishing an Integrated Working Group of Doctors and Nurses in Operating Room
To explore the preventive effect and clinical enlightenment of establishing an integrated working group of doctors and nurses in operating room on incision infection in orthopedic surgery.
- Trial name
- NCT06579599
- Testing
- an integrated working group nursing
- Where
- China
- Volunteers
- 130 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Surgical Wound Infection, Vascular Surgery
Supplemental Oxygen in Vascular Surgery
The purpose of this study was to test the hypothesis that supplemental postoperative oxygen reduces the risk of surgical wound infection in patients following lower limb vascular surgery.
- Trial name
- NCT00873704
- Testing
- supplemental postoperative oxygen
- Where
- 6 sites in Finland
- Volunteers
- 274 people
- Sponsor
- North Karelia Central Hospital
Medical Thoracoscopy
Surgical Site Preparation in Subjects Undergoing Medical Thoracoscopy
Medical thoracoscopy is the preferred procedure for performing pleural biopsy in patients with pleural effusions that remain undiagnosed after pleural fluid analysis.
- Trial name
- CAPTAIN (NCT05430308)
- Testing
- Chlorhexidine scrub, Povidone-iodine
- Where
- 2 sites in India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Open Fracture, Post-Op Wound Infection
Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens
To demonstrate noninferiority of three different empiric antimicrobial regimens compared to the traditional antimicrobial regimen for the management of grade III open fractures as well as evaluate outcomes among these groups.
- Trial name
- NCT03560232
- Testing
- Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mercy Health Ohio
Orthopedic Surgery
Biofilm Formation and Antibiotic Sensitivity Patterns
Detection of bacteria that form biofilm and its sensitivity to antibiotics in patients with surgical site infection after orthopedic surgery.
- Trial name
- NCT05181163
- Testing
- swab
- Volunteers
- 100 people
- Sponsor
- Sohag University