Clinical trials: Infection, Surgical Site
Surgery, Multiorgan Failure
The Influence of Nursing Technique Applied at the Central Venous Catheter Insertion Site Upon the Incidence of Infection
Assessing the impact of the nursing technique applied at the insertion site of the central venous catheter using hydrophilic methacrylate gel (HMG) and 2% Chlorhexidine (CHG) upon the incidence of inflammatory complications when…
- Conditions
- Surgery, Multiorgan Failure, Haematologic Disease
- Trial name
- NCT03875352
- Testing
- CHG technique, HMG technique
- Where
- Czechia
- Volunteers
- 221 people
- Sponsor
- University Hospital Ostrava
Negative-Pressure Wound Therapy, Wound Heal
Compare Stoma Reversal Wound Outcomes Between NPWT and Secondary Intention Healing
This was a single-center, parallel-group randomized controlled trial conducted in 2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- Negative-Pressure Wound Therapy, Wound Heal, Stoma Site Infection, Surgical Site Infection
- Trial name
- NCT07258134
- Testing
- Negative Pressure Wound Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Maryam Arbab
Colorectal Surgery, Wound Infections
REDWIL: Reduction of Wound Infections in Laparoscopic Colon Resections by Wound Protectors
Surgical site infection is common in colorectal surgery leading to increased postoperative pain, longer hospital stay, delayed wound healing and increased re-operation rates.
- Trial name
- REDWIL (NCT01049971)
- Testing
- wound protector, no wound protector
- Where
- Germany
- Volunteers
- 109 people
- Sponsor
- Charite University, Berlin, Germany
Cesarean Section Complications, Wound Breakdown
Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery
This will be an open label pilot randomized controlled clinical trial. Women undergoing cesarean delivery will be randomized to have standard wound dressing care or chlorohexidine gluconate (CHG) impregnated wound dressing…
- Conditions
- Cesarean Section Complications, Wound Breakdown, Wound Infection, Satisfaction
- Trial name
- NCT03887299
- Testing
- ReliaTect™ Post-Op Dressing (contains chlorohexidine gluconate or CHG), Standard Wound Care
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Surgical Site Infection, Surgical Wound Infection
Floraseal Versus Iodine Impregnated Adhesive Drapes
Infection after total joint arthroplasty can have devastating consequences. Adhesive drapes have been traditionally used at our institution to help reduce the risk of wound contamination and infection by superficial skin flora.
- Trial name
- NCT03466489
- Testing
- Floraseal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Post Operative Surgical Site Infection
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2
The PRCT evaluates infection outcomes as well as fracture and antibiotic-related complications to include the emergence of resistant bacteria associated with two different antibiotic strategies in the treatment of Gustilo type…
- Trial name
- SEXTANT 2 (NCT04678154)
- Testing
- Standard of care, Vancomycin and Tobramycin
- Where
- 31 sites in United States
- Volunteers
- 600 people
- Sponsor
- Major Extremity Trauma Research Consortium
Surgery
Operating Room Air Filtration/Sterilization
Determine whether operating room air filtration and sterilization with the ActivePure system reduces a composite of serious surgical site infections, infection-related complications, and death within 30 days after surgery.
- Trial name
- ORACLE (NCT04610294)
- Testing
- Functioning Aerus air filtration/sterilization, Deactivated Aerus air filtration/sterilization
- Where
- United States
- Volunteers
- 66,273 people
- Sponsor
- The Cleveland Clinic
Suture Line Infection
Subcutaneous Continuous Versus Interrupted Sutures During Cesarean Section.
A comparison of the rate of surgical site infections after cesarean section depending on the type of suture used for subcutaneous closure-continuous versus interrupted.
- Trial name
- NCT04220294
- Testing
- Subcutaneous tissue closure
- Where
- Israel
- Volunteers
- 1,238 people
- Sponsor
- Rambam Health Care Campus
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz
Surgical Site Infection
Roles of Prophylactic Subcutaneous Drain in Preventing Surgical Site Infection in Surgical Wound After Abdominal Surgery
Surgical site infections (SSI) pose a common challenge in the field of surgery. Current evidence and literature do not provide clear consensus whether the use of subcutaneous drainage will help reduce the incidence of SSI in…
- Trial name
- NCT06063629
- Testing
- Subcutaneous drain, No drain
- Volunteers
- 180 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Surgical Site Infection, Groin Hernia
Prophylactic Antibiotics in Groin Hernioplasty
The role of prophylactic antibiotics in preventing surgical site infections (SSI) for clean procedures like groin hernia repair remains controversial.
- Conditions
- Surgical Site Infection, Groin Hernia, Hernioplasty
- Trial name
- NCT07111702
- Testing
- Cefazolin
- Where
- Yemen
- Volunteers
- 100 people
- Sponsor
- Sana'a University
Surgical Site Infections, Nosocomial Infection
Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute…
- Conditions
- Surgical Site Infections, Nosocomial Infection, Healthcare Associated Infections
- Trial name
- BENEFIT-PDT (NCT05090657)
- Testing
- methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Ondine Biomedical Inc.
Human Papillomavirus Infection, Stage I Oral Cavity Squamous Cell Carcinoma
Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer
This pilot clinical trial studies how well durvalumab before surgery works in treating patients with oral cavity or oropharynx cancer.
- Conditions
- Human Papillomavirus Infection, Stage I Oral Cavity Squamous Cell Carcinoma, Stage I Oropharyngeal Squamous Cell Carcinoma, Stage II Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT02827838
- Testing
- Durvalumab, Laboratory Biomarker Analysis, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Surgical Site Infection
Wound Protector Dual-ring Alexis® in Pancreaticoduodenectomy
Surgical site infection (SSI) is a leading cause of preventable morbidity and mortality in North America and worldwide. This condition has consistently been reported to account for up to 25% of all healthcare-associated…
- Trial name
- PALEXIS (NCT03820648)
- Testing
- Alexis, Standard 3M™ Steri-Drape 2
- Where
- Italy
- Volunteers
- 212 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Surgical Site Infection, Colorectal Cancer
Comparison of Method for Skin Closure in Colorectal Cancer.
Compared to tissue adhesives and skin stapling devices, tissue adhesives are reported to have advantages in terms of wound infection and cost competitiveness.
- Trial name
- NCT06549803
- Testing
- skin bond, skin stapler
- Where
- South Korea
- Volunteers
- 304 people
- Sponsor
- Yoon Suk Lee
Surgical Site Infection
INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Surgery
The goal of this observational study is to contribute to a better understanding of the perioperative kinetics of intestinal microbial composition and association with surgical site infections.
- Trial name
- INTRA (NCT05775341)
- Testing
- No Intervention
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes, Hyperglycemia
The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery
The purpose of this study was to investigate the effects of three different glycemic treatment conditions (tight, conventional, and standard) in the intraoperative period on: 1) postoperative surgical site infections, and 2)…
- Conditions
- Diabetes, Hyperglycemia, Surgical Site Infection
- Trial name
- NCT01831154
- Testing
- Tight Glycemic, Conventional Glycemic, Standard Glycemic
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Wound of Skin
Reducing Surgical Site Infection Rates Using an Alternative Sternal Dressing
This study will evaluate two alternative dressings compared to a standard Island dressing presently in use at Stanford Hospital to determine reductions in surgical site infection (SSI) rates among cardiac surgery patients.
- Trial name
- NCT03346694
- Testing
- Standard Island Dressing, Prevena Negative Pressure wound dressing, Mepilex Border Post-Op Ag
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Stanford University
Infection Due to Coronary Artery Bypass Graft (Diagnosis)
Surgical Wound Infection Prevention Bundle in Patients Undergoing Coronary Bypass Graft Surgery
estimate the utilization of locally customized surgical wound infection bundle to prevent and or control of infection in patients undergoing CABG surgery in Sohag
- Trial name
- NCT07003750
- Testing
- Surgical wound infection prevention bundle
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic