Clinical trials: Infection, Surgical Site
Breast Cancer
Does a Preoperative Prophylactic Antibiotic Reduce Surgical Site Infection Following Wire-localized Lumpectomy
Background: Data on the benefits of preoperative prophylactic antibiotics for breast surgery are conflicting and there is no guideline for their use for wire-localized lumpectomy.
- Trial name
- NCT04818931
- Testing
- Cefazolin Injection
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- CHU de Quebec-Universite Laval
Surgical Site Infection
SMS-Based Follow-Ups to Improve Post-Discharge Surgical Outcomes
The purpose of this study is to determine whether low-cost Short Message Service (SMS)-based follow-up medication reminders and surveys for surgical site infection (SSI) reporting can improve outcomes by increasing medication…
- Trial name
- NCT03161262
- Testing
- SMS-based reminders
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Emory University
Surgical Site Infection Following Cesarean Delivery
Comparison of Surgical Skin Preps During Cesarean Deliveries
In women that undergo non-emergency cesarean delivery, we are comparing the skin preparation solutions for best outcome of surgical site infection.
- Trial name
- NCT01870583
- Testing
- Iodine povidone, Chlorhexidine, Combination iodine and chlorhexidine
- Where
- 2 sites in United States
- Volunteers
- 1,404 people
- Sponsor
- Montefiore Medical Center
Surgical Site Infection
The Use of Diluted Povidone Iodine Irrigation in Spine Surgery
The purpose of the study is to determine whether diluted Povidone Iodine solution used to irrigate surgical wounds during spine surgery decreases the incidence of surgical site infections.
- Trial name
- NCT01577524
- Testing
- Povidone-Iodine, Saline
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Attabib, Najmedden, M.D.
Surgical Wound Infection
Multicenter Infection Surveillance Study Following Colorectal Procedures
This study is a multicenter, open label, observational, postmarketing surveillance study of the ON-Q® Silver SoakerTM in the United States and Canada.
- Trial name
- MISS (NCT00762060)
- Testing
- ON-Q Silver soaker System, Patient controlled analgesia
- Volunteers
- 289 people
- Sponsor
- Halyard Health
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Lower Limb Ischaemia, Aneurysm
Bacterial Growth in Vascular Surgery Wounds
The amount and species of bacteria have been shown to have an effect in wound infections in several fields of surgery (such as gastrointestinal and orthopaedic surgery and the surgery of facial area).
- Trial name
- NCT01505738
- Testing
- bacterial samples
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- North Karelia Central Hospital
Breast Cancer
Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation
The investigators intend to perform a prospective randomized study and compare the incidence of surgical wound infection between mastectomy wounds irrigated with triple antibiotic solution (one side) and 0.05% CHG (opposite side)…
- Trial name
- NCT02395614
- Testing
- Chlorhexidine irrigation, triple antibiotic irrigation
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal (Colon or Rectal) Cancer, STOMACH NEOPLASM
Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery
This study aims to evaluate whether monitoring perioperative inflammatory and metabolic biomarkers can help identify postoperative complications early in adult patients undergoing colorectal or gastric cancer surgery.
- Trial name
- PERIO-BIO (NCT07881133)
- Testing
- Perioperative Biomarker-Guided Monitoring
- Where
- Romania
- Volunteers
- 320 people
- Sponsor
- Bucharest Emergency Hospital
Neurosurgery
Surgical and Non-surgical Infections of Neurosurgical Patient: Before-after Cohort Study
Continuous surveillance in 2003-2017 allowed to detect HAIs in patients staying in a 42-bed neurosurgery unit with 6 intensive neurosurgical supervision beds. 10,332 surgical patients were qualified for the study.
- Trial name
- NCT03759652
- Testing
- before-after study
- Where
- Poland
- Volunteers
- 10,332 people
- Sponsor
- Polskie Towarzystwo Zakażeń Szpitalnych
Infection
Effect of Surgical Wound Infection on Health
A surgical site infection (SSI) is an infection that occurs after surgery in the part of the body
- Trial name
- NCT04134338
- Testing
- To evaluate the effect of wound infection on costs
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Aljazeera Hospital
Surgical Site Infection
Reducing Wound Infections Using Bioelectric Wound Dressings
The purpose of this study is to compare the outcomes of using Bioelectric wound dressing on the pre-operative wound site and post operatively and compared it outcomes to the standard of care chlorhexidine skin preparation.
- Trial name
- JumpStart (NCT06312267)
- Testing
- Bioelectric dressing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AdventHealth
Wound Surgical, Wound Infection
PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post…
- Conditions
- Wound Surgical, Wound Infection, Cosmesis
- Trial name
- PINTA (NCT06025253)
- Testing
- Negative Pressure Wound Therapy, Standard Wound Dressing
- Where
- 7 sites in Ireland
- Volunteers
- 728 people
- Sponsor
- Royal College of Surgeons, Ireland
Surgical Site Infection, Postoperative Complications
Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs
Surgical site infection (SSI) is a major postoperative complication after abdominal surgery especially in colorectal field, which significantly increases length of stay (LOS), readmission incidence and expense.
- Conditions
- Surgical Site Infection, Postoperative Complications, Bowel Preparation, Oral Antibiotics
- Trial name
- NCT03856671
- Testing
- Neomycin,metronidazole
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Post-Operative Wound Infection
A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery
The aim of this study was to investigate the effect of an oxytetracycline impregnated gauze drain on the incidence of alveolar osteitis (AO) and postoperative pain during the first week after mandibular third molar surgery.
- Trial name
- Wisdomsteeth (NCT03494972)
- Testing
- Tetracyclin ointment
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Colorectal Disorders, Colorectal Neoplasms
Value of Butyrylcholinesterase as a Marker of Surgical Site Infection Following Surgery for Colorectal Diseases
Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. BchE's serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.
- Trial name
- NCT04748744
- Testing
- Butyrylcholinesterase
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- University Hospital of Patras
Postoperative Wound Infection
Study of the Efficacy of Plain Soap and Water Versus Alcohol-based Rubs for Surgical Hand Preparation
Surgical site infections (SSI) constitute a significant health-economic and clinical challenge. The investigators conducted a cluster-randomized, cross-over study to compare the efficacy of plain soap and water (PSW), used…
- Trial name
- NCT00987402
- Testing
- Plain soap and water (PSW), Alcohol-based hand rub (ABHR)
- Where
- Kenya
- Volunteers
- 3,317 people
- Sponsor
- University Hospital, Geneva
Osteoarthritis, Infection
Prospective, Randomized Study Evaluating The Efficacy of Chlorhexidine Gluconate Impregnated No-Rinse Cloths.
Subjects in the study were randomized to a treatment group using Chlorhexidine cloths or a standard-of-care group who only had a bath with antibacterial soap and water.
- Trial name
- SAGE (NCT02469311)
- Testing
- chlorhexidine impregnated cloths, Standard of care bathing with antibacterial soap and water
- Volunteers
- 539 people
- Sponsor
- LifeBridge Health
Cesarean Section; Infection, Surgical Site Infection
Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline
The purpose of this study is to see whether chlorhexidine is superior to povidine-iodine vaginal antisepsis at reducing bacteria colony counts in pregnant women by comparing three groups: vaginal washing with…
- Trial name
- NCT03640507
- Testing
- Chlorhexidine-alcohol, Povidine-iodine, Sterile saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Colorectal Cancer
Inflammation Biomarkers in the Diagnosis of Postoperative Infectious Complications in Colorectal Cancer Surgery
This is a longitudinal, single-center, prospective study to determine the efficiency of WBC Count, CRP, PCT, Neutrophil CD64 and Monocyte Human Leukocyte Antigen- DR in the diagnosis of postoperative infectious complications in…
- Trial name
- NCT03559335
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation