Clinical trials: Infection Abdominal
Appendicitis
Appendectomy vs. Symptomatic Treatment in Uncomplicated Acute Appendicitis Among Pediatric Patients
The APPSYPP trial is a randomized national multicenter feasibility superiority pilot study comparing appendectomy with symptomatic treatment in children with imaging-confirmed uncomplicated acute appendicitis.
- Trial name
- APPSYPP (NCT05289713)
- Testing
- appendectomy
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Helsinki University Central Hospital
Appendicitis, Abdominal Abscess
Laparoscopic Management of Periappendicular Abscess
According to retrospective studies the conservative management of periappendicular abscess is associated with decreased complication and re-operation rate compared with open appendectomy.
- Trial name
- NCT01283815
- Testing
- Laparoscopic appendectomy, Conservative management with percutaneous drainage
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Abdominal Sepsis
Assessment of Peritoneal Immune Response in Patients With Severe Intra-abdominal Sepsis Managed With Laparostomy and Vacuum Assisted Closure (VAC)
Protocol Synopsis Protocol title: Assessment of peritoneal immune response in patients with severe intra-abdominal sepsis managed by laparostomy and VAC Purpose: Assessment of peritoneal immune response in patients with severe…
- Trial name
- NCT01410526
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Liver Abscess, Amoebic Liver Abscess
Efficacy of Diloxanide Furoate as Additional Luminal Agent Along With Metronidazole for the Treatment of Amoebic Liver Abscess
Liver abscess is a common cause of presentation to medical emergency. Among the various causes of liver abscess, Amoebic liver abscess (ALA) is a frequent cause that can resemble pyogenic infections in tropical regions.
- Trial name
- DFALA RCT (NCT07807150)
- Testing
- Diloxanide furoate
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Abdominal Pain, Acute Pain
Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions
The goal of this non-inferiority observational study is to assess the diagnostic performance of low-dose CT with deep learning image reconstruction (DLIR) in adult participants with acute abdominal conditions.
- Conditions
- Abdominal Pain, Acute Pain, Acute Cholecystitis, Acute Appendicitis
- Trial name
- DETECT_Acute (NCT05651360)
- Testing
- low-dose CT
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 246 people
- Sponsor
- Oslo University Hospital
Irritable Bowel Syndrome
Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel…
- Trial name
- NCT05830370
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Appendicitis Acute
Leave or Laparoscopic Appendectomy With Normal Findings - a Regional Cohort Study
Based on a regional cohort, this study we will try to demonstrate the superiority of routine laparoscopic appendectomy vs. leaving an intraoperative assessed normal appendix in situ in cases of normal findings at diagnostic…
- Trial name
- NCT06000020
- Testing
- Laparoscopic appendectomy
- Where
- 4 sites in Denmark
- Volunteers
- 1,435 people
- Sponsor
- Nordsjaellands Hospital
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Peritonitis
Role of Protective Stoma After Primary Anastomosis for Generalized Peritonitis Due to Perforated Diverticulitis
This study is designed to be a multicentre, prospective, comparative, randomised trial, evaluating the efficacy of two surgical strategies for the treatment of generalised peritonitis due to perforated diverticulitis.
- Trial name
- DIVERTI2 (NCT04604730)
- Testing
- Primary anastomosis without protective stoma, Anastomosis with protective stoma
- Where
- 20 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Rouen
Intra Abdominal Infections
Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI)
This is a prospective, Phase 3, randomized, multi-center, double-blind study of the efficacy, tolerability and safety of sulopenem followed by sulopenem-etzadroxil/probenecid versus ertapenem followed by…
- Trial name
- NCT03358576
- Testing
- Ertapenem, Sulopenem-Etzadroxil/Probenecid, Ciprofloxacin
- Where
- 42 sites in United States, Bulgaria and 5 more
- Volunteers
- 674 people
- Sponsor
- Iterum Therapeutics, International Limited
Appendicitis
Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study
1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound for pediatric appendicitis.
- Trial name
- NCT02507674
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP)
Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE
Why This Study is Needed Some bacterial infections have become resistant to common antibiotics, making them very difficult to treat. This is a growing and serious health problem.
- Conditions
- Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
- Trial name
- AWARE (NCT07268560)
- Testing
- Aztreonam-Avibactam
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Appendicitis
Role of Wound Irrigation After Appendectomy
Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection.
- Trial name
- NCT03773224
- Testing
- Irrigation
- Where
- Egypt
- Volunteers
- 179 people
- Sponsor
- Mansoura University
Inguinal Hernia
Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair
Aim of this study is to measure the effectiveness of topical gentamicin to prevent post-operative infection in inguinal tension-free hernia repair operation.Secondary aim is, if it is effective as a prophylactic agent, to compare…
- Trial name
- NCT01273818
- Testing
- Gentamicin and cefazolin, Cefazolin, Gentamicin
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Diskapi Teaching and Research Hospital
Appendicolith, Appendicitis
Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome
Laparoscopy has revolutionized the approach to a number of surgical problems causing a re-evaluation of several clinical strategies.
- Conditions
- Appendicolith, Appendicitis, Appendicitis With Perforation, Appendicitis Peritonitis
- Trial name
- LAPSUS (NCT03770897)
- Testing
- 3D Laparoscopic Appendectomy, 2D Laparoscopic Appendectomy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Ventral Hernia
Repair of Large Incisional Hernias - To Drain or Not to Drain Randomised Clinical Trial
The aim of this study was to perform a randomised clinical trial comparing the use of closed-suction tubular drains and progressive tension sutures in individuals with large incisional hernias subjected to onlay mesh repair to…
- Trial name
- NCT02163460
- Testing
- Drain, Progressive Tension Sutures
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Oeste do Paraná
Peritonitis
Children Peritonitis Ecology at CHU de Rennes - (IIAPEDIA)
The main objectif is assess the germs (species + antibiograms) implicated in children intra-abdominal infections (community acquired or nosocomial ) at CHU de Rennes.
- Trial name
- IIAPEDIA (NCT03668197)
- Testing
- microbiological analysis
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Rennes University Hospital
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Gut Microbiota, Intra-abdominal Infections
Gut Microbiota Analysis in IAI Patients With Sepsis-associated Liver Dysfunction
With the rapid development of intensive care medicine, the mortality of patients with sepsis has decreased over the past decade, but it is still the leading cause of death in intensive care unit (ICU).
- Conditions
- Gut Microbiota, Intra-abdominal Infections, Acute Gastrointestinal Injury, Sepsis-associated Liver Dysfunction
- Trial name
- 2022-11-09 (NCT05628493)
- Testing
- Gut microbiota Analysis
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese Medical Association