Clinical trials: Infection Prophylaxis
Stigma, Social, Drug Abuse Illicit
Lower Intersecting HIV-related Stigmas to Facilitate Treatment as Prevention (LIFT)
The purpose of this study is to reduce HIV transmission risk among people who inject drugs (PWID) through a multilevel intervention known as LIFT.
- Conditions
- Stigma, Social, Drug Abuse Illicit, HIV (Human Immunodeficiency Virus)
- Trial name
- LIFT (NCT07541131)
- Testing
- LIFT for People Who Use Drugs, LIFT for MMT Providers
- Where
- Kyrgyzstan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Covid19
SARS-CoV-2 Pre-exposure Prophylaxis With Ivermectin Retrospective Cohort Study
This observational study, a multicenter retrospective cohort database study, carried out in two medical centers, Centro Medico Bournigal (CMBO) in Puerto Plata and Centro Medico Punta Cana (CMPC) in Punta Cana, Dominican…
- Trial name
- NCT04832945
- Testing
- Ivermectin 6 Mg Oral Tablet
- Where
- 2 sites in Dominican Republic
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- Grupo Rescue S.A.S República Dominicana
White Spot Lesion of Tooth, Gingival Inflammation
EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIAL
This clinical trial aims to learn if water floss is as efficient as other interdental cleaning tools and can prevent plaque accumulation and white spot lesions (WSLs) in orthodontic patients.
- Conditions
- White Spot Lesion of Tooth, Gingival Inflammation, Gingival Bleeding, Dental Plaque
- Trial name
- WATER FLOSS (NCT06752291)
- Testing
- water flosser
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Anthrax
VELOCITY: An Anthrax Vaccine Clinical Study
This study is designed to evaluate the lot consistency (using three consecutively manufactured lots), safety, and ability of the AV7909 anthrax vaccine to generate an immune response in healthy adults and compare the response to…
- Trial name
- NCT03877926
- Testing
- AV7909, BioThrax
- Where
- 35 sites in United States
- Volunteers
- 3,689 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Novel 2009 Influenza H1N1, Influenza, Human
Tolerability and Immunogenicity Study of FLUVAL P H1N1 Flu Vaccine of Omninvest in Children and Adolescents
This is a single-blind, reference drug controlled study to assess safety and tolerability of FLUVAL P H1N1 monovalent influenza vaccine (whole virus, inactivated, adjuvanted with alumn phosphate gel) containing 6 mcgHA per 0.5mL…
- Trial name
- NCT01407978
- Testing
- Vaccination with Fluval P monovalent influenza vaccine, Vaccination with Fluval AB, Vaccination with Fluval AB Novo
- Where
- Hungary
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
COVID-19
Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19
The HCW Prophylaxis (HCWP) Study, single, open and off label intervention study. Up to 350 participants will be assigned to group that takes HCQ or group that opts to not take study medication.
- Trial name
- NCT04435808
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
HIV-1-infection, Antenatal Care
An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women
This study is composed of two parallel, pilot randomized groups that will obtain preliminary data about the the acceptability, fidelity, and clinical outcomes associated with a multi-component adherence support strategy for HIV…
- Trial name
- NCT04330989
- Testing
- iNSC and Adherence supporter training
- Where
- Malawi
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Common Cold, Gastroenteritis
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
We hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the…
- Trial name
- NCT00231218
- Testing
- dietary supplement--echinacea, propolis, and vitamin c
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diphtheria, Tetanus
REVAXIS® Versus DT Polio® as a Second Booster in 6 Year-old Children
Primary objective: To demonstrate the non inferiority between REVAXIS® and DT Polio® when given as a second booster to healthy 6 year-old children . Secondary objectives: Additional immunogenicity assessments.
- Conditions
- Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT00447525
- Testing
- REVAXIS®, DT-Polio®
- Where
- 64 sites in France
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Covid19, SARS (Severe Acute Respiratory Syndrome)
Safety and Efficacy of Hydroxychloroquine for the Treatment & Prevention of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Coronavirus Disease 2019 (COVID-19) (previously called 2019-nCOV acute respiratory disease) is caused by SARS-CoV-2, a positive-sense single-stranded RNA virus of the coronavirus family.
- Trial name
- NCT04590274
- Testing
- Hydroxychloroquine, Vitamins and Minerals, Azithromycin
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Brain Research Foundation
HIV, Sexually Transmitted Infections
Multicomponent Intervention to Reduce Sexual Risk and Substance Use
The objective is to expand and refine an intervention for transgender women (TW) into a 7-session individual- and group-based intervention that is scalable for community settings to reduce sexual risk and substance use and to…
- Conditions
- HIV, Sexually Transmitted Infections, Substance Use
- Trial name
- NCT01880489
- Testing
- MI + CBST Intervention
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Healthy
VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases
This protocol will screen healthy normal volunteers for participation in studies of vaccines under development at NIAID's Vaccine Research Center. Of interest are vaccines for: Newly identified infectious diseases such as SARS.
- Trial name
- NCT00068926
- Where
- 2 sites in United States
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative…
- Trial name
- NCT00164255
- Testing
- sulfadoxine/pyrimethamine, sulfadoxine/pyrimethamine plus artesunate
- Where
- 2 sites in Tanzania
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Human Papillomavirus-Related Cervical Carcinoma
Single Dose of Cervarix Vaccine in Girls or Three Doses of Gardasil Vaccine in Women for the Prevention of Human Papillomavirus Infection, the PRIMAVERA-ESCUDDO Trial
This phase IIIb trial compares a single dose of the Cervarix vaccine in girls to 3 doses of the Gardasil vaccine in young women for the prevention of human papillomavirus (HPV) infection.
- Trial name
- PRIMAVERA (NCT03728881)
- Testing
- Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Hiv, HSV
Safety, PK, and PD Study of a Vaginal Insert Containing TAF and EVG
The purpose of this Phase I study is to assess the safety, pharmacokinetics, and pharmacodynamics of a combination vaginal insert containing tenofovir alafenamide (TAF) and elvitegravir (EVG).
- Trial name
- NCT03762772
- Testing
- TAF/EVG Vaginal Insert
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- CONRAD
Anthrax
Immunogenicity and Safety Study of a Three-Dose BioThrax® Regimen for Post-Exposure Prophylaxis in Healthy Adults
The purpose of this Phase 3 clinical trial is to evaluate the immunogenicity and safety of BioThrax anthrax vaccine in healthy adults following 3 doses of BioThrax.
- Trial name
- NCT01491607
- Testing
- BioThrax
- Where
- 4 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Hepatitis B
Persistence of the Immune Response to Hepatitis B in 4-6 Years Old Children Previously Vaccinated With DTPa-HBV-IPV/Hib
Persistence of seroprotective antibody concentrations \& immunological memory shown by the ability to mount a response to a challenge dose of HBV vaccine
- Trial name
- NCT00335881
- Testing
- hepatitis B vaccine
- Where
- 38 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections, Anti-Infective Agents
Acceptability Study of Vaginal Films for HIV Prevention
This study is being done to find out what women would want in a film vaginal product for human immunodeficiency virus (HIV) prevention, especially what it should look like and how to apply it.
- Trial name
- FACE (NCT01231763)
- Testing
- No intervention (not applicable)
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Surgical Site Infection
Antibiotics for Prevention of SSI in Obese Women Undergoing CS
Effect of cephalexin plus metronidazole on SSI better than cephalexin alone in obese women undergoing CS
- Trial name
- NCT03736187
- Testing
- Cephalexin
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Human Immunodeficiency Virus, Stigma, Social
Mitigating Sexual Stigma Within Healthcare Interactions Improve Engagement of MSM in HIV Prevention
The purpose of this study is to explore drivers and mitigators of anal sex stigma in healthcare, and then to develop and pilot an intervention for health workers that mitigates the deterrent effects of this stigma on the…
- Conditions
- Human Immunodeficiency Virus, Stigma, Social, Patient Engagement
- Trial name
- NCT04779736
- Testing
- A set of implementation strategies to reduce sexual stigma
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
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