Clinical trials: Infection Prophylaxis
HIV/AIDS
Community-based, Peer-delivered PrEP for Female Sex Workers in Rural Uganda: The Peers for PrEP (P4P) Study
The overall goal of the P4P: Peers for PrEP (pre-exposure prophylaxis) study is to pilot test a peer-led and delivered intervention for biomedical HIV prevention that is tailored to women who engage in sex work in southwestern…
- Trial name
- P4P (NCT06353295)
- Testing
- P4P intervention
- Where
- Uganda
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Surgical Wound Infection
Vacuum Assisted Closure for Cesarean Section
To study if incisional vacuum-assisted closure can decrease the risk of infection in cesarean section incisions in the obese compared with standard sterile dressing.
- Trial name
- VACCS (NCT02390401)
- Testing
- Vacuum-assisted closure, Standard sterile dressing
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
HIV Infections
Evaluate Tolerability of a Multi-envelope, Prime-boost HIV Vaccine in Healthy Adults
Vaccines have been very successful in preventing viral infections such as hepatitis B and the measles. Viral vaccines work by causing a person's immune system to make cells that will work against the virus.
- Trial name
- NCT00623753
- Testing
- EnvDNA, PolyEnv1, EnvPro
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Neonatal Sepsis, Omphalitis
A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
Introduction: Neonatal sepsis in one of the leading cause of death in developing countries. Umbilical cord care is important as it may lead to infection.
- Trial name
- NCT06002295
- Testing
- Chlorhexidine Topical Cream, Methylated Spirit
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Relapsing Fever, Tick-Borne
Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever
The goal of this clinical trial is to compare standard treatment (5 days of doxycycline) vs single dose doxycycline for the prevention of tick-borne relapsing fever in soldiers who found bite marks on their bodies after an…
- Trial name
- NCT06045481
- Testing
- administration of single dose of doxycycline
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Infantile Diarrhea
Prophylaxis of Gastrointestinal Infections With EcN
This interventional trial shall investigate the efficacy and tolerance of a suspension with non-pathogenic probiotic E. coli strain Nissle (EcN) on prophylaxis against gastrointestinal infections in newborn and infants.
- Trial name
- PIURA (NCT01469273)
- Testing
- Mutaflor® Suspension
- Where
- 3 sites in Peru
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hospital San Bartolome
Pneumonia
Effects of the Oral Care With Vaccines for Pneumonia in Elderly; Going Home Together Both Physician and Dentist
Prospective study comparing the effects of interventions (combined oral care and pneumococcal plus influenza vaccinations) in preventing pneumonia and increasing the survival rate from pneumonia.
- Trial name
- NCT01403805
- Testing
- Pneumococcal vaccination (Pneumovax NP, 21800AMY10131000), Influenza vaccination (Flubik HA, 16100EZZ01207000), Specific frequency of oral care
- Where
- Japan
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Yubari Kibounomori
HIV Infections
Botswana Study of UC-781 Vaginal Microbicide
This study will test the safety, side effects, and acceptability of two strengths of UC-781 gel when used by women and men in Botswana for two weeks.
- Trial name
- NCT00385554
- Testing
- UC-781 carbomer gel, 0.1% and 0.25%
- Where
- 3 sites in United States, Botswana
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, HIV-1-infection
Prospective Observational Cohort HIV & STI Study in Europe
The University Hospital Essen is sponsoring the Multicenter human immunodeficiency virus (HIV) and sexually transmitted infections Prevention Network Study (STIPnet) which is funded by Janssen, Pharmaceutical Companies of Johnson…
- Conditions
- HIV Infections, HIV-1-infection, Risk Reduction, Sexual Behavior
- Trial name
- NCT03866759
- Testing
- Determine the Incidence and Point Prevalence
- Where
- 15 sites in France, Hungary and 3 more
- Volunteers
- 3,593 people, healthy volunteers welcome
- Sponsor
- Hendrik Streeck
Malaria
A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children
In countries of the Sahel and sub-Sahel, malaria transmission is highly seasonal with nearly all infections occurring during a few months of the year.
- Trial name
- NCT00132561
- Testing
- Sulfadoxine/pyrimethamine and artesunate
- Where
- Senegal
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Diarrheal Disease, Acute Respiratory Infection
"Alcohol Based Hand Sanitizers for the Prevention of Acute Diarrheal Disease and Acute Respiratory Infection in Children Under 5 Attending Childcare Centers in Bogotá, Cundinamarca and Tolima, in Colombia: a Cluster Randomized Control Trial"
The purpose of this study is to conduct a Randomized Control Trial (RCT) in a developing country setting in order to evaluate the role of alcohol based hand sanitizers (ABHS) in preventing the transmission of infectious diseases…
- Trial name
- NCT00963391
- Testing
- ABHS use
- Where
- Colombia
- Volunteers
- 1,727 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Meningitis, Meningococcal
Ciprofloxacin for the Prevention of Meningococcal Meningitis
This study evaluates the effect of antibiotic prophylaxis with ciprofloxacin, given to the contacts of meningitis cases, on the overall attack rate of meningitis during an epidemic.
- Trial name
- NCT02724046
- Testing
- Ciprofloxacin
- Where
- Niger
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Epicentre
Urinary Tract Infection
High Strength Cranberry Supplementation for Prevention of Recurrent Urinary Tract Infection
This clinical trial is a Phase 2, multicenter, placebo-controlled, double-blind, parallel-arm study to evaluate the efficacy and safety of High Strength Cranberry (500mg Pacran®) in preventing UTI (cystitis) in women with a…
- Trial name
- NCT03042273
- Testing
- High Strength Cranberry
- Where
- 5 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Swisse Wellness Pty Ltd
Infection in Bone
Evaluation of VSS Antibiotic Prophylaxis in Prosthetic Surgery (MRSA)
based on international guide lines, antibiotic prophylaxis in Orthoaedic major surgery has to be done with a Cephalosporin 1st generation (e.g. Cefazolin 1 g 30' before surgery).
- Trial name
- MRSA (NCT06403254)
- Testing
- There isn't an intervention name because the study is observational and has only one group.
- Where
- Italy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
HIV Infections
A Gender-Enhanced Pre-Exposure Prophylaxis (PrEP) Information-Motivational Workshop for Young South African Women
This is a phase 1 pilot study to assess feasibility and acceptability and potential for impact of a gender-enhanced virtual group workshop focused on oral Pre-Exposure Prophylaxis (PrEP) as an HIV prevention method for young…
- Trial name
- Masibambane (NCT04833127)
- Testing
- Gender-Enhanced -- Masibambane, Individually accessed
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
SARS-CoV-2
PROTECT-APT 1: Early Treatment and Post-Exposure Prophylaxis of COVID-19
This study is an adaptive, randomized, double blind, platform trial evaluating promising investigational products (IP) for safety and efficacy as early outpatient treatment and post-exposure prophylaxis for Severe Acute…
- Trial name
- PROTECT-APT 1 (NCT05954286)
- Testing
- Upamostat
- Where
- 6 sites in United States, South Africa and 2 more
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Malaria
Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers.
This trial aims to characterise the pharmacokinetic (PK) profile and estimate drug exposure of a single oral dose of piperaquine (PQP) in a dispersible granule formulation compared to the PQP hard tablet formulation in the fasted…
- Trial name
- PedPQP(BA/FE) (NCT05930782)
- Testing
- Piperaquine Tetraphosphate uncoated tablets, Piperaquine Tetraphosphate dispersible granules
- Where
- Tanzania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
HIV Infections
Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults
The purpose of this study is to determine the safety and the immune responses to the HIV vaccine candidate, MVA-CMDR. This vaccine was designed to induce immune responses to three HIV "passenger" genes encoded with the viral…
- Trial name
- NCT00376090
- Testing
- MVA-CMDR
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Social Stigma, Substance Use Disorders
Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care
This is a community-engaged research project that aims to identify and pilot test interventions that may reduce substance use stigma among professionals at primary care sites serving patients who might be exposed to HIV or are…
- Conditions
- Social Stigma, Substance Use Disorders, HIV Infections, Physician-Patient Relations
- Trial name
- NCT05925374
- Testing
- Substance use stigma training
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Wayne State University
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