Clinical trials: Infection Prophylaxis
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
MRSA Infections
Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis
This study prospectively selects the patients to examine the effectiveness of the investigators' current standard of prophylaxis prior to vascular surgery and to compare the effectiveness of vancomycin and daptomycin plus…
- Trial name
- NCT00967941
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Hepatitis C, HepatoCellular Carcinoma
STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention
Aim 1: The investigators will conduct a randomized controlled trial comparing two strategies to promote HCV screening, follow-up testing, and treatment among baby-boomers (i.e.
- Trial name
- NCT03706742
- Testing
- Mailed outreach
- Where
- United States
- Volunteers
- 12,386 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Antibiotic Prophylaxis, Wound Infection
The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients
This study aims to investigate the impact of antibiotic prophylaxis on reducing wound infection rates following open repair of primary elective groin hernias in high-risk patients.
- Conditions
- Antibiotic Prophylaxis, Wound Infection, Groin Hernia
- Trial name
- NCT06576154
- Testing
- Cefazolin 1000 MG
- Where
- Syria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aleppo
Endophthalmitis
Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis
- Trial name
- NCT03244072
- Testing
- Moxifloxacin
- Where
- United States
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Jason Ahee, M.D.
HIV/AIDS
PHAT Life: Peer Versus Adult-Led HIV Prevention for Juvenile Offenders
This application proposes a 2-arm randomized controlled trial comparing the impact of PHAT Life on 350 13-17 year-old offenders' risky sex, STI, substance use, and theoretical mediators when delivered by Youth Representatives…
- Trial name
- PHATLife (NCT03555279)
- Testing
- PHAT Life: Preventing HIV/AIDS Among Teens--PS Arm, PHAT Life: Preventing HIV/AIDS Among Teens--YR Arm
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Tuberculosis
Study of the Safety and Efficacy of the Subunit Recombinant Tuberculosis Vaccine GamTBvac
This study is a multicenter, double-blind, randomized, placebo-controlled Phase III trial designed to evaluate the efficacy and safety of the GamTBvac recombinant subunit tuberculosis vaccine for the prevention of active…
- Trial name
- NCT04975737
- Testing
- GamTBvac
- Where
- Russia
- Volunteers
- 9,500 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Respiratory Syncytial Virus Infection Prevention
A Study to Evaluate the Immunogenicity and Safety of a Recombinant Respiratory Syncytial Virus Vaccine in Older Adults Aged 60 Years and Older
This is a randomized, observer-blinded, placebo-controlled Phase Ⅱ clinical trial to evaluate the immunogenicity and safety of the Respiratory Syncytial Virus (RSV) Vaccine, LYB005 in participants aged 60 years and older.
- Trial name
- NCT07208461
- Testing
- Low dose antigen of LYB005 without A01B adjuvant, Low dose antigen of LYB005 with A01B adjuvant, Middle dose antigen of LYB005 without A01B adjuvant
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Pneumonia, Diarrhea
Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia.
- Conditions
- Pneumonia, Diarrhea, Acute Upper Respiratory Tract Infections
- Trial name
- NCT00228254
- Testing
- Zinc (12.5 mg/day), vitamin A 10,000 IU per week
- Where
- 2 sites in United States, Ecuador
- Volunteers
- 2,582 people, healthy volunteers welcome
- Sponsor
- Tufts University
Substance Use, Delinquency
Juvenile Detention to Community Life
The fundamental objective of the proposed study is to develop and test an innovative two-stage, cross-systems family-based intervention for substance abusing juvenile offenders.
- Conditions
- Substance Use, Delinquency, Risk for HIV Infection
- Trial name
- DTC (NCT01910324)
- Testing
- Multidimensional Family Therapy Cross-Systems, Enhanced Services as Usual
- Where
- 5 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Miami
Bacteriuria
Dosing Study of Cranberry Capsules for the Prevention of Bacteriuria in Nursing Home Residents
This study will investigate whether there is a particular dose of cranberry capsules that is effective in preventing the occurrence of urinary tract infections in females at least 65 years of age or older who live in a nursing…
- Trial name
- NCT01033383
- Testing
- Cranberry Capsule
- Where
- 14 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale University
Sepsis
Prevention of Infection in Indian Neonates - Phase II Probiotics Study
India, with one of the world's largest populations, continues to struggle with extremely high infant and neonatal mortality rates.
- Trial name
- NCT00518596
- Testing
- Probiotic supplementation (Lactobacillus plantarum)
- Where
- 3 sites in India
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Plasmodium Falciparum Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Myanmar
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05025761
- Testing
- Personal protection package
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
HIV Infections, HIV Primary Infection
A Couples-based Intervention for Transgender Women and Their Partners
This project seeks to test the efficacy of a couples-based HIV prevention program in large-scale randomized controlled trial (RCT) to reduce HIV risk among transgender woman and their partners.
- Trial name
- T2 (NCT04067661)
- Testing
- CHIP, Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Michigan
HIV Infection
Effectiveness of the Diaphragm for HIV Prevention
The purpose of this trial is to determine whether using the diaphragm and a lubricant get can reduce women's risk of acquiring an HIV infection.
- Trial name
- NCT00121459
- Testing
- Ortho All-Flex diaphragm and Replens lubricant gel
- Where
- 3 sites in South Africa, Zimbabwe
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Infections, Sexually Transmitted Diseases
HIV Prevention Program for Patients Receiving Care at a Sexually Transmitted Diseases Clinic
This study will determine the effectiveness of a two-step HIV prevention program in reducing risky sexual practices and decreasing the incidence of sexually transmitted diseases (STDs).
- Trial name
- NCT00183573
- Testing
- Brief Motivational Intervention, Brief Informational Intervention, Intensive Informational Intervention
- Where
- United States
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Covid19, Coronavirus
QuadraMune(TM) for Prevention of COVID-19
QuadraMune(TM) is a nutritional supplement which has previously been demonstrated to possess antiinflammatory and immune modulatory activity based on in vitro and pilot in vivo studies.
- Conditions
- Covid19, Coronavirus, SARS-CoV 2
- Trial name
- NCT04421391
- Testing
- QuadraMune(TM)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Therapeutic Solutions International
Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention
Preventing Health Damaging Behaviors in Male and Female Army Recruits
Health damaging (risk) behaviors of young military personnel are reflections of health problems facing all young people in the U.S.
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention, Sexual Risk Reduction, Alcohol and Other Substance Use Prevention
- Trial name
- NCT01234103
- Testing
- Preventing Helath Damaging Health Behaviors in Male and Female Army Recruits
- Where
- United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Rabies
A Randomized Phase II Trial to Compare the Safety and Neutralizing Activity of CL184 in Combination With Rabies Vaccine vs. HRIG or Placebo in Combination With Rabies Vaccine in Healthy Adult Subjects
The aim of this study is to evaluate the safety of the monoclonal antibody cocktail CL184 in combination with rabies vaccine compared with human rabies immune globulin (HRIG) or placebo in combination with rabies vaccine in…
- Trial name
- NCT00656097
- Testing
- CL184, HRIG
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
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