Clinical trials: Infection Prophylaxis
Tuberculosis, Hiv
A Pragmatic Randomised Study to Optimise Screening, Prevention and Care for Tuberculosis in Malawi
A pragmatic open, three-arm individually-randomised controlled trial and economic evaluation will be conducted in one primary health care centre in Blantyre, Malawi, where HIV and TB are major contributors to early mortality.
- Conditions
- Tuberculosis, Hiv, Tuberculosis, Pulmonary
- Trial name
- PROSPECT (NCT03519425)
- Testing
- Optimised HIV screening and linkage to care, Optimised tuberculosis screening and linkage to care
- Where
- Malawi
- Volunteers
- 1,455 people
- Sponsor
- Liverpool School of Tropical Medicine
Sexual Risk Behavior for HIV-Infection
Effect Study of a Theory-Based Internet Intervention on Safe-Sex Practices
The purpose of this study is to examine the efficacy of a theory based, online tailored intervention on stimulating safe-sex practices among men who have sex with men (MSM).
- Trial name
- NCT00378885
- Testing
- Cognitive-behavioral tailored intervention
- Where
- Netherlands
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Public Health Service of Amsterdam
Shoulder Arthropathy Associated With Other Conditions, Shoulder Arthritis
Microcurrent Dressing to Treat Infections, Before, During and After Surgery
Deep periprosthetic infection following total joint arthroplasty is a major complication. Although it only occurs in a small percentage of patients (~1%), it results in substantial morbidity and a decline in functional outcome.
- Conditions
- Shoulder Arthropathy Associated With Other Conditions, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Pain
- Trial name
- NCT03156543
- Testing
- Jumpstart Dressing, Standard Dressing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Malaria,Falciparum
Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)
This is a randomized, three-arm, open-label, clinical trial of malaria chemoprevention in children with sickle-cell anemia (SCA) at a single site in Homa Bay, Kenya.
- Trial name
- EPiTOMISE (NCT03178643)
- Testing
- Proguanil Oral Tablet, Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ), Dihydroartemisinin-Piperaquine (DP)
- Where
- Kenya
- Volunteers
- 246 people
- Sponsor
- Duke University
Malaria
School-Based Treatment With ACT to Reduce Transmission
We propose to evaluate the community-level impact of intermittent preventive treatment (IPT) for malaria in schoolchildren on clinical outcomes and malaria transmission, using a cluster-randomised design in Jinja, Uganda.
- Trial name
- START-IPT (NCT02009215)
- Testing
- Dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 10,746 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Catheter-Associated Urinary Tract Infection
Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
The specific aim of this randomized double-blind placebo-controlled trial is to evaluate the efficacy of administration of nitrofurantoin prophylaxis after catheter discontinuation for the prevention of catheter-associated…
- Trial name
- NAUTICA (NCT03287089)
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Wake Forest University Health Sciences
HIV/AIDS and Infections
Strategies for the Prevention of Hepatitis B Among HIV Infected Patients in Uganda
The aim of this study is to compare the effectiveness of two vaccination strategies against Hepatitis B virus (HBV) in subjects already infected with human immunodeficiency virus (HIV).
- Trial name
- NCT02316444
- Testing
- Hepatitis B vaccine
- Where
- Uganda
- Volunteers
- 132 people
- Sponsor
- Fred Hutchinson Cancer Center
Infection Wound, Antibiotic Resistant Infection
The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy
Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.
- Trial name
- NCT06607887
- Testing
- IV antibiotic, Oral antibiotic
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Minia University Hospital
Rabies
Immunogenicity of Rabies Vaccine for Pre Exposure Prophylaxis
The purpose of this study is to compare the effectiveness of a two dose versus a three dose schedule and intramuscular versus intradermal injection for pre-exposure prophylaxis.
- Trial name
- RABVAX (NCT02374814)
- Testing
- Rabies vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Clostridioides Difficile Infection
Prevention of Recurrence of Clostridioides Difficile Colitis With Ursodeoxycholic Acid (UCDA) as a Supplement to Standard Therapy
The goal of this clinical trial is to determine whether Ursodeoxycholic Acid (UDCA) can help prevent recurrence of Clostridioides difficile (C. diff) colitis when used along with standard antibiotic treatment. C.
- Trial name
- PREVENT (NCT06884748)
- Testing
- Ursodiol 500 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Human Immunodeficiency Virus
Mobile Messaging Intervention to Present New HIV Prevention Options for Men Who Have Sex With Men (MSM)
The study will evaluate the use and effectiveness of mobile-messaging platforms as a public health strategy for improving sexual health outcome measures among men who have sex with men (MSM) by determining whether exposure to the…
- Trial name
- MMI4MSM RCT (NCT03666247)
- Testing
- HealthMindr Application, Waitlist
- Where
- 3 sites in United States
- Volunteers
- 1,229 people, healthy volunteers welcome
- Sponsor
- Emory University
Prenatal Exposure Delayed Effects, Antibiotic Prophylaxis
Prenatal Antibiotics and Breast Milk / Neonatal IgA
In this biological study, the investigators will evaluate the levels of breast milk IgA, neonatal fecal IgA, and the composition of breast milk and fecal microbiota throughout the first 12 months of life in neonates born to…
- Conditions
- Prenatal Exposure Delayed Effects, Antibiotic Prophylaxis, Dysbiosis, Neonatal Infection
- Trial name
- PAIGAN 1 (NCT05813184)
- Testing
- Antibiotics
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
HIV-infected Participants With Latent TB Infection in High TB Burden Country
Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals
The investigators want to know if ultra-short, effective treatment for latent tuberculosis (TB) infection (LTBI) could dramatically reduce the global incidence of active TB or not.
- Trial name
- NCT03785106
- Testing
- Isoniazid/Rifapentine daily (4 weeks) plus pyridoxine (vitamin B6), Isoniazid/Rifapentine 12-weekly plus pyridoxine (vitamin B6)
- Where
- 16 sites in Thailand
- Volunteers
- 2,500 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Influenza A, Pandemic Influenza
H7HLAII DNA Influenza Vaccine
The purpose of this study is to assess safety and immunogenicity of H7HLAII, a DNA vaccine encoding influenza hemagglutinin (HA) from influenza A/Shanghai/2/2013 (H7N9) directed to cells expressing human leukocyte antigen class…
- Trial name
- H7N9vax-1 (NCT06046092)
- Testing
- H7HLAII
- Where
- Norway
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cytomegalovirus Infections, HIV Infections
A Study of Valacyclovir Hydrochloride in the Prevention of Life-Threatening Cytomegalovirus Disease in HIV-Infected Patients
PRIMARY: To evaluate the efficacy of valacyclovir hydrochloride (BW 256U87) in the prevention of cytomegalovirus (CMV) end-organ disease in HIV/CMV co-infected patients with CD4+ lymphocytes < 100 cells/mm3.
- Trial name
- NCT00001038
- Testing
- Valacyclovir hydrochloride, Acyclovir
- Where
- 35 sites in United States, Australia and 8 more
- Volunteers
- 1,200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Invasive Pulmonary Aspergillosis, Lymphoblastic Leukaemia
Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia
The trial evaluates the overall tolerability of the drug and the efficacy of aerosolised amphotericin B as a lipid complex (ABLC) for primary prophylaxis of invasive pulmonary aspergillosis (IPA) in pediatric patients with acute…
- Conditions
- Invasive Pulmonary Aspergillosis, Lymphoblastic Leukaemia, Myeloblastic Leukaemia, Lymphoblastic Leukemia
- Trial name
- NCT01615809
- Testing
- AMPHOTERICIN B
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundació Sant Joan de Déu
Pregnancy, Human Immunodeficiency Virus
'HI-4-TU' Study: Health Improvement for Teen Ugandans Study
This randomized clinical trial is an adolescent focused implementation science study directed at improved social support and prevention of both HIV/STI's and subsequent unplanned pregnancies.
- Conditions
- Pregnancy, Human Immunodeficiency Virus, Sexually Transmitted Diseases
- Trial name
- NCT02845284
- Testing
- enhanced group support, enhanced individual support
- Where
- Uganda
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 4
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER4 (NCT05587738)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Monash University
Pediatric Cancer, Pediatric Oncology
Central Venous Catheter Care Training for Pediatric Oncology Nurses
The knowledge level of nurses regarding care techniques plays a crucial role in the prevention of central venous catheter-related infections.
- Conditions
- Pediatric Cancer, Pediatric Oncology, Central Venous Catheter, Central Venous Catheter Placement
- Trial name
- NCT07345598
- Testing
- CVC Care Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Human Immunodeficiency Virus, Virus Shedding
The Compartmental Biology of HIV in the Male Genital Tract
Male participants taking tenofovir-emtricitabine (TDF/FTC) will provide semen and blood samples which will be analyzed to better understand the pharmacology of antiretroviral therapy in the male genital tract.
- Trial name
- NCT02638493
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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