Clinical trials: Infection Prophylaxis
Sexual Health, Sexually Transmitted Infection (STI)
Gamified Interactive Narrative (REPRO-QUEST) on Sexual Health Literacy and Sexually Transmitted Infection Prevention Behaviors
This randomized controlled trial evaluates the effectiveness of an analog gamification-based interactive narrative intervention (REPRO-QUEST) on enhancing sexual health literacy and behaviors aimed at protecting against sexually…
- Conditions
- Sexual Health, Sexually Transmitted Infection (STI), Health Literacy
- Trial name
- REPRO-QUEST (NCT07886073)
- Testing
- REPRO-QUEST Interactive Narrative, Educational Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Surgical Site Infection, Antibiotic Prophylaxis
The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.
This study will seek to describe current practice of antibiotic prophylaxis to identify the effect of appropriate perioperative antimicrobial coverage - specifically regarding timing, dose adjustments, and redosing - on surgical…
- Trial name
- NCT03982810
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
HIV Infections, Sexually Transmitted Infections
HIV Prevention Program for African American Teen Males
The purpose of this study is to test if sexual health interventions can reduce the incidence of STIs among African American teens (15 to 21 years old).
- Trial name
- NCT00849823
- Testing
- Male Sexual Health Program, Focus on the Future Program
- Where
- United States
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Richard Crosby
Coronavirus Infection
Prevention of Coronavirus Disease (COVID-19) Outbreaks With Nitazoxanide
The new coronavirus outbreak has led to a public health emergency of international concern, putting all health organizations on high alert.
- Trial name
- NCT04406246
- Testing
- Nitazoxanide 500Mg Oral Tablet
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Respiratory Syncytial Viruses, Lower Respiratory Tract Disease
A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older
The study will enroll up to 27,200 participants in order to demonstrate the efficacy of the active Ad26.RSV.preF-based study vaccine in the prevention of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed…
- Trial name
- EVERGREEN (NCT04908683)
- Testing
- Adenovirus serotype 26 (Ad26)-based respiratory syncytial virus (RSV). preF
- Where
- 272 sites in United States, Australia and 12 more
- Volunteers
- 25,236 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Human Immunodeficiency Virus, Mental Health
Digital Star: HIV Prevention for Youth in Mental Health Treatment
Teenagers in mental health treatment are at greater risk for HIV and other sexually transmitted infections. This greater risk comes from many factors, some of which are related to poor emotion regulation and low self-confidence.
- Trial name
- DSTAR (NCT02921841)
- Testing
- D*STAR, D*HEALTH
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Rhode Island Hospital
Late Onset Neonatal Sepsis
Lactoferrin for Prevention of Sepsis in Infants
The investigators propose a clinical trial in premature infants to determine the effect of orally-administered bovine lactoferrin on occurrence of severe infections and to determine whether as a result of decreased infections…
- Trial name
- NEOLACTO (NCT01525316)
- Testing
- Bovine Lactoferrin, Maltodextrin
- Where
- 3 sites in Peru
- Volunteers
- 414 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Nosocomial Infections, MRSA Colonization
Comparison of Two Protocols to Prevent the Acquisition of Methicillin-Resistant Staphylococcus Aureus.
Nosocomial infections is a major problem in intensive care units due to both growing incidence and pathogens implicated which become increasingly resistant to antibiotics.
- Trial name
- NCT00151606
- Testing
- Reinforced isolation + Muciprocine
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Rennes University Hospital
Malaria
Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in Children
Intermittent preventive treatment (IPT) offers a way of preventing malaria infection without compromising the development of malaria immunity or encouraging drug resistance.
- Trial name
- NCT00561899
- Testing
- SP, amodiaquine, piperaquine, dihdroartemisinin, intermittent preventive treatment, Du-Cotecxin
- Where
- The Gambia
- Volunteers
- 1,295 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hiv
Regional Multicenter Study to Evaluate Tolerability and Efficacy of TAF/FTC/RPV Combination (ODEFSEY ®) in Prevention of Sexual or Blood Exposure to HIV
Prospective, multicenter study to evaluate tolerability, adherence and efficacy of a 28-day course of TAF/FTC/RPV, an HIV post-exposure prophylaxis after a potential sexual or blood exposure to HIV.
- Trial name
- AES ODEFSEY (NCT03451032)
- Testing
- Non Interventional Study
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Prevention of COVID19
Immunogenecity and Safety of VaccinemRNA-1273 in Elderly Volunteers (Over 65 y) Compared to Younger Ones (18-45y)
This study aims to evaluate the immunogenicity of Moderna mRNA-1273 vaccine in volunteers aged 65 years or more compared to volunteers aged 18-45 years, over 24 months duration.
- Trial name
- CoviCompareM (NCT04748471)
- Testing
- mRNA-1273
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Human Immunodeficiency Virus
Use of the Shang Ring Circumcision Device in Boys Below 18 Years Old in Kenya
A proof of concept study to evaluate the feasibility of using the Shang Ring, a novel male circumcision device across all childhood age groups namely infants (under 1), 1-5 age group, 6-12 age group and the 13-17 age group.
- Trial name
- NCT01891409
- Testing
- Male circumcision using the Shang Ring device
- Where
- Kenya
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- EngenderHealth
Catheter-Associated Urinary Tract Infection, Ascorbic Acid
Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries
This open-label randomized trial aims at assessing the role of Vitamin C pills in the prevention of catheter-associated urinary tract infections in women undergoing elective gynecological surgeries.
- Trial name
- NCT03800667
- Testing
- Ascorbic Acid 1000 MG
- Where
- Lebanon
- Sponsor
- American University of Beirut Medical Center
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Candidiasis, Oral, HIV Infections
A Study of Nystatin in the Prevention of Fungal Infections of the Mouth in Patients With AIDS or AIDS-Related Syndromes
To determine a safe, effective, and convenient dosing schedule for nystatin pastilles in the prophylaxis of oral candidiasis in patients with AIDS or AIDS related syndromes (group III or IV, CDC classification)
- Trial name
- NCT00002293
- Testing
- Nystatin
- Where
- 2 sites in United States
- Sponsor
- Bristol-Myers Squibb
Prostate Infection
Antibiotic Prophylaxis for Transrectal Prostate Biopsy-Ciprofloxacin vs. Trimethoprim/Sulfamethoxazole
This study will examine if a single dose of Ciprofloxacin and Trimethoprim/Sulfamethoxazole are equivalent for prophylaxis immediately prior to prostate biopsy, when a patient has a suspected prostate cancer.
- Trial name
- NCT02734732
- Testing
- Trimethoprim/Sulfamethoxazole, Ciprofloxacin
- Where
- 5 sites in Sweden
- Volunteers
- 2,800 people
- Sponsor
- Umeå University
Uro-genital Schistosomiasis
Prevention of Female Genital Schistosomiasis (FGS) in Rural High-endemic South Africa
Schistosomiasis is a poverty-related water-transmitted parasitic disease affecting more that 200 million people world wide. Infection with Schistosoma haematobium may cause Female Genital Schistosomiasis (FGS) with pathological…
- Trial name
- VIBE-FGS (NCT01154907)
- Testing
- Praziquantel
- Where
- South Africa
- Volunteers
- 6,500 people
- Sponsor
- Oslo University Hospital
COVID-19
The Covid-19 Outpatient Symptom Montelukast Oximetry Trial
Primary care physicians face limited availability of therapeutic options for the treatment of COVID-19 in the outpatient setting.
- Trial name
- COSMO (NCT04389411)
- Testing
- Montelukast 10mg
- Volunteers
- 250 people
- Sponsor
- McGill University
Influenza, Human, Respiratory Tract Infections
A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants
The main purpose of the study is to evaluate the efficacy of a single dose of baloxavir marboxil compared with placebo in the PEP of influenza virus infection with respect to symptomatic, laboratory-confirmed influenza in…
- Conditions
- Influenza, Human, Respiratory Tract Infections, Post-exposure Prophylaxis
- Trial name
- Pearlstone (NCT07827599)
- Testing
- Baloxavir marboxil
- Where
- 8 sites in China
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Covid19, SARS-CoV Infection
COVID-19 Prophylaxis South Africa (COVER HCW)
This is a randomised, multi-center, open label, adaptive, exploratory trial to assess the efficacy of two different drug regimens in terms of preventing symptomatic COVID-19 disease in healthcare workers at high risk of exposure…
- Trial name
- COVER (NCT04561063)
- Testing
- Nitazoxanide, Sofosbuvir/Daclatasvir
- Where
- 2 sites in South Africa
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
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