Clinical trials: Infection Wound
Wound Infection, Sugar Solution
High Concentration of Sugar Solution Irrigation Promotes the Healing of Infected Wound
Surgeons easily get wound infections. Most wound infections will be cured by applying medicines and changing dressing in very short period of time.
- Trial name
- NCT02945761
- Testing
- High concentration of sugar solution, conventional surgical dressing change
- Volunteers
- 3 people
- Sponsor
- Ningbo Municipal No.4 Hospital
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Infection
VeraFlo With Prontosan® and Wound and Fracture Healing.
To answer the question: "Do Prontosan instillations decrease time to wound and fracture healing and decrease bacterial load compared to wound vac treatment without Prontosan?," we will enroll up to 30 subjects (for an anticipated…
- Trial name
- NCT02621073
- Testing
- VeraFlo with Prontosan, V.A.C Ulta System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brett Crist
Cardiac Surgery, Sternal Wound Infection
Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection
The purpose of this study is to determine whether the gentamicin-collagen sponge is safe and effective in preventing sternal wound infections in patients undergoing cardiac surgery who are at a greater risk of developing sternal…
- Trial name
- NCT00600483
- Testing
- gentamicin-collagen sponge dipped in saline
- Where
- 43 sites in United States
- Volunteers
- 1,502 people
- Sponsor
- Innocoll
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Surgical Site Infection
Intradermal Suture Versus Stapling for Groin Skin Closure in Vascular Surgery (VASC-INF Trial)
Surgical site infection (SSI) is one of the most frequent and fearsome complications in vascular surgery due to its high morbidity and mortality.
- Trial name
- NCT05434182
- Testing
- Intradermal Suture, Metallic Staples
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Non Infected Wounds, Non Infected Post Surgical Wounds
A Prospective, Open, Non-controlled Clinical Investigation to Evaluate a New Negative Pressure Wound Therapy (NPWT) System to be Used in the Treatment of Acute Non-infected Wounds and Post Surgical Infected Wounds
The investigation is designed as a prospective, open, non-controlled clinical investigation.
- Trial name
- NCT01195896
- Testing
- New NPWT system
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Molnlycke Health Care AB
Surgical Site Infection, Anastomotic Leak
Oral Antibiotic Prophylaxis in Colorectal Surgery
The investigators perform a case-control study to compare preparation before elective colorectal surgery. The first group is a prospective patient - registry in all patients with mechanical bowel preparation (MBP) and oral…
- Trial name
- ABCR (NCT03759886)
- Testing
- Paromomycin Sulfate Powder
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Surgical Site Infection
DFA-02 in Patients Undergoing Colorectal Surgery
This is a randomized, double-blind, placebo controlled, safety, tolerability, and pharmacokinetic dose escalation Phase II study of DFA-02 in patients undergoing colorectal surgery to evaluate the safety, tolerability and…
- Trial name
- NCT01496352
- Testing
- DFA-02
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Coronavirus Infection
ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection
This is a randomized, double-blind placebo-controlled trial to investigate the efficacy and safety of tradipitant 85 mg orally given twice daily to treat inflammatory lung injury associated with severe or critical COVID-19…
- Trial name
- NCT04326426
- Testing
- Tradipitant
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanda Pharmaceuticals
Surgical Site Infections
Examination of the Effect of Skin Antisepsis With Pre-heated Povidone Iodine on Surgical Site Infections: A Quasi-Experimental Study
Surgical Site Infections (SSI) develop as a complication of surgical care 30-90 days after surgery without implants and within 1 year after implanted operations.
- Trial name
- NCT04969302
- Testing
- Follow-up
- Where
- Cyprus
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Kidney Injury, Kidney Failure
Personalization of Immunosuppressive Treatment for Organ Transplant Recipients
Long-term graft failure rates continue to be unacceptably high despite the development of immunosuppressive drugs, underscoring the unmet need for robust prognostic biomarkers of allograft injury and failure.
- Conditions
- Kidney Injury, Kidney Failure, Kidney Failure, Chronic, Kidney Failure, Acute
- Trial name
- STAART (NCT05747053)
- Testing
- AlloSure, PAXGene
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- George Washington University
Fractures, Bone, Infections
Clinical Metagenomic of Post-traumatic Infections
Treatment of fracture related infection is challenging and often lead to failure in such situation that carry a high health cost burden.
- Trial name
- METADIAG (NCT05770856)
- Testing
- Metagenomic sequencing
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Wound Contamination
Prospective Randomised Study for Use of CHG Dressing at Entry Site of EVD's to Reduce EVD-associated Infections
The objective of this study is to assess the efficacy of 3M™ Tegaderm™ CHG I.V. Securement Dressing at the entry-site of a EVD in reducing quantity of microorganisms (CFU/cm2) after a time period of 5 days as a surrogate marker…
- Trial name
- EVDAI (NCT02078830)
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Hospital, Basel, Switzerland
Complicated Skin and Skin Structure Infections
Efficacy and Safety Study of JNJ-32729463 for Treating Complicated Skin and Skin Structure Infections Compared to Linezolid (Zyvox)
The purpose of this study is to determine the clinical efficacy, safety, and tolerability of a 250 mg BID oral dose of JNJ-32729463 compared with linezolid in subjects with complicated skin and skin structure infections (cSSSIs).
- Trial name
- NCT01128530
- Testing
- JNJ-32729463, linezolid
- Where
- 27 sites in United States
- Volunteers
- 161 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Old World Cutaneous Leishmaniasis
Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan
A four (4) -arm randomised control clinical trial to evaluate miltefosine, thermotherapy and the combination miltefosine-thermotherapy are effective, safe and tolerable alternative treatment options to treat cutaneous…
- Trial name
- NCT04268524
- Testing
- drug: miltefosine with thermotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 645 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Aseptic Loosening, Infection
Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
The objectives of this clinical investigation are to evaluate the safety and performance of the Freedom Total Knee® PCK System.
- Conditions
- Aseptic Loosening, Infection, Bone Loss, MCL - Medial Collateral Ligament Rupture of the Knee
- Trial name
- NCT03312088
- Testing
- Freedom Knee PCK Components
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Trauma, COVID-19 Pandemic
The Impact of the Covid-19 Pandemic on Orthopedic Trauma Management
The aim of the study is to compare emergency orthopedic trauma admissions between the pre-pandemic period and the pandemic period and to detect changes in orthopedic trauma epidemiology.
- Trial name
- NCT06237023
- Testing
- epidemyolojical
- Where
- Turkey (Türkiye)
- Volunteers
- 57,635 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Surgical Site Infection
Wound Infection in Obese Women After Cesarean Delivery
The purpose of this study is to determine the surgical site infection rate and patient satisfaction for absorbable versus non absorbable suture in closure of skin at cesarean section in obese women.
- Trial name
- NCT01679379
- Testing
- Absorbable suture group, Non absorbable suture group
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
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