Clinical trials: Infection Wound
Surgical Site Infection, Skin Colonization
Dressing Wear Time After Reduction Mammaplasty
This study was designed to determine whether the duration of dressing wear following reduction mammaplasty influence skin colonization and surgical site infections rates.
- Trial name
- NCT01002391
- Testing
- reduction mammaplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Daniela Francescato Veiga
Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries
Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.
Patients with heart attack or heart injury are tested (angiogram) for blockages in their arteries. Patients may develop heart problems caused by damage to small (microvascular) blood vessels.
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries, Myocardial Injury
- Trial name
- StratMedMINOCA (NCT05198791)
- Testing
- Stratified medicine - Microvascular dysfunction and eplerenone therapy, tablets, Stratification and standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- NHS National Waiting Times Centre Board
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
CoronaVirus Induced Disease-2019 (COVID-19)
Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Lung failure is the main cause of death related to COVID-19 infection.
- Trial name
- iNSPIRE (NCT04375397)
- Testing
- Ibrutinib
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- AbbVie
Surgical Wound Infection
Trial Investigating Cyanoacrylate Glue to Prevent Surgical Site Infection Following Breast Surgery
Surgical Site Infections (SSI) represents a significant complication in plastic surgery. Infections can result in a prolonged recovery and impair long-term cosmetic appearance.
- Trial name
- NCT02779296
- Testing
- 2-Octyl Cyanoacrylate Glue
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Organ Failure, Multiple, Inflammation
Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery
The REDJUVENATE Trial proposes to test the hypothesis that postoperative organ injury and inflammation will be less if patients undergoing cardiac surgery who are at risk of large volume blood transfusion (defined as the…
- Conditions
- Organ Failure, Multiple, Inflammation, Sepsis
- Trial name
- NCT03167788
- Testing
- rejuvesol Solution, Standard Care
- Where
- United Kingdom
- Sponsor
- University of Leicester
Covid19
CRP-Apheresis for Attenuation of Pulmonary, MYocardial and/or Kidney Injury in COvid-19
The 'CAPMYKCO' study is a randomized controlled, open-label, single center proof of concept trial. The aim of this study is to evaluate whether a CRP-apheresis in addition to the current standard therapy is intended to mitigate…
- Trial name
- CAPMYKCO (NCT04898062)
- Testing
- CRP-apheresis
- Where
- 4 sites in Germany
- Sponsor
- Pentracor GmbH
Obstetric Trauma, Infections
Oral Antibiotics After Obstetric Perineal Tear
The purpose of this study is to investigate if 3 dose of oral antibiotics administrated the first day after a vaginal delivery with a second degree obstetric tear will decrease the risk of infection and/or wound dehiscence…
- Conditions
- Obstetric Trauma, Infections, Wound Dehiscence
- Trial name
- REPAIR (NCT05830162)
- Testing
- Bioclavid (Amoxicillin and Clavulanic acid)
- Where
- Denmark
- Volunteers
- 442 people
- Sponsor
- Hanna Jangö
Covid19, Myocardial Injury
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or…
- Conditions
- Covid19, Myocardial Injury, Cardiovascular Diseases, Heart Failure
- Trial name
- CARDIO-COVID (NCT04624503)
- Where
- 5 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Humanitas Hospital, Italy
Acute Kidney Injury, Sepsis
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
Brief Summary: Evaluating a New Phosphate-Containing Fluid for Blood Purification (CRRT) Why is this study being done? Patients in the Intensive Care Unit (ICU) often need a treatment called Continuous Renal Replacement Therapy…
- Conditions
- Acute Kidney Injury, Sepsis, Critically Ill Patients Requiring Continuous Renal Replacement Therapy
- Trial name
- PHOS-CRRT (NCT07550894)
- Testing
- Phosphate-containing Replacement Fluid, Standard Phosphate-free Replacement Fluid
- Where
- 15 sites in China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Wound, Bacterial Infections
Biofilm Modified Macrophage Phenotype and Function in Diabetic Wound Healing
The purpose of this study is to learn more about biofilm and to see how it affects diabetic wounds. A biofilm can occur if a chronic infection causes bacteria to grow in a slime enclosed group.
- Conditions
- Wound, Bacterial Infections, Diabetes Mellitus, Infected Ulcer of Skin
- Trial name
- NCT03271580
- Testing
- Finger prick test for HbA1c measurement, Punch Biopsy, Vac Sponge Collection
- Where
- 5 sites in United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Infection, Surgical Site
Effectiveness and Clinical Application of MolecuLight Bacterial Fluorescence Imaging in Wound Debridement
MolecuLight is a device that utilizes a special light which, when used on wounds, helps identify the regions which pathogenic bacterial counts are the highest.
- Trial name
- NCT04541394
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
HIV Infections, HIV Seronegativity
A Study of Male Rectal Samples in Preparation for Future Rectal Microbicide Trials
Microbicides are drugs that destroy microbes such as viruses and bacteria. Rectal microbicides may be able to prevent transmission of HIV during anal intercourse.
- Trial name
- NCT00075062
- Testing
- Flexible Sigmoidoscopy, Rectal Biopsy
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Diseases, Obstructive, Sarcoidosis
Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")
The purpose of this study is to evaluate the safety, effectiveness, and side effects of the CryoSpray AblationTM System (CryoSpray AblationTM, "CSA" or "cryospray therapy") to treat benign airway disease in the lung using liquid…
- Conditions
- Lung Diseases, Obstructive, Sarcoidosis, Wegener's Granulomatosis, Rhinoscleroma
- Trial name
- ICEtheBAD (NCT00747461)
- Testing
- CryoSpray Ablation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- CSA Medical, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
DETEC® Esterase for Screening Wound Infection at Point of Care
This non-interventional, single-blinded, prospective, observational study assesses the planar distribution of leukocyte esterase in wounds by placing wound exudates soaked wound dressings in the DETEC® Esterase device during…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
- Trial name
- NCT04614870
- Testing
- DETEC® Esterase
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Progenitec Inc.
Hip Fractures, Pneumonia
The Effect of Zoledronate on the Prevention of Pneumonia in Hip Fracture Patients
Nitrogen-containing bisphosphonates (N-BPs; such as alendronate and zoledronate) are commonly used in the treatment of osteoporosis and fracture prevention, in which zoledronate has a proven better efficacy than alendronate.
- Trial name
- Zoo-P (NCT05743179)
- Testing
- Zoledronate
- Where
- 5 sites in Hong Kong
- Volunteers
- 2,692 people
- Sponsor
- The University of Hong Kong
Surgical Site Infection
Effect of Barbed Suture and Triclosan-coated Monofilament in Emergency Surgery
Patients will be randomized 3 groups: Group 1: Abdominal fascial closure will be performed with Triclosan-coated barbed Polydioxanone suture Group 2:Abdominal fascial closure will be performed with Triclosan-coated monofilament…
- Trial name
- NCT03763279
- Testing
- Triclosan-coated barbed suture, Triclosan-coated monofilament suture, Monofilament suture
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Elche
Bacterial Infections, Antibiotic Resistant Infection
Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan
The main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern Jordan.
- Conditions
- Bacterial Infections, Antibiotic Resistant Infection, Surgical Site Infection
- Trial name
- NCT05106803
- Testing
- ciprofloxacin
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Yarmouk University
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure
Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS
This study assesses the clinical effectiveness of mammalian target of rapamycin (mTOR) inhibition with rapamycin in minimizing or decreasing the severity of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure, Sars-CoV2
- Trial name
- RAPA-CARDS (NCT04482712)
- Testing
- Rapamycin
- Where
- 2 sites in United States
- Sponsor
- The University of Texas Health Science Center at San Antonio
Sepsis, Myocardial Injury
COronary Microcirculation and Troponin Elevation in Septic Shock
Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known.
- Conditions
- Sepsis, Myocardial Injury, Coronary Microvascular Dysfunction, Endothelial Dysfunction
- Trial name
- COMTESS (NCT06294730)
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
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