Clinical trials: Infection and Inflammatory Reaction
Infection and Inflammatory Reaction, Joint Prosthesis
Chronic Pain, Inflammation and Infection After Joint Replacement
Revision surgery after total hip or knee arthroplasty is an ongoing issue due to an increasing number of primary surgeries. Patients seek physicians due to pain. The cause is divided between loosening, infection or chronic pain.
- Trial name
- NCT02177097
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Urinary Tract Infection Complicated, Acute Pyelonephritis
Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults
Vabomere™, (meropenem-vaborbactam) is being compared to the Best Available Therapy in the treatment of adults with selected serious infections due to Carbapenem Resistant Enterobacteriaceae
- Conditions
- Urinary Tract Infection Complicated, Acute Pyelonephritis, Hospital Acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
- Trial name
- NCT02168946
- Testing
- Vabomere, Best Available Therapy
- Where
- 50 sites in United States, Argentina and 6 more
- Volunteers
- 77 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Endophthalmitis
Severe Intraocular Infection
The host-immune reaction to infection is essential for the comprehension of the disease and the development of new therapies. The aim of the study is to describe intraocular cytokines network in aqueous humor using multiplex…
- Trial name
- NCT02818062
- Testing
- Cytokines dosage in Aqueous humor
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Strasbourg, France
Malaria
Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays
Background: Malaria is a disease caused by parasites transmitted to people by mosquitoes. Around the world, there were 241 million cases and 627,000 deaths from malaria in 2020.
- Trial name
- NCT06607003
- Testing
- P. vivax challenge agent derived from PvHMB-CCE001
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Urinary Tract Infection, Fluoroquinolone
Clinical Impact of Fluoroquinolone Resistance in Bacteremia Caused by Gram-Negative Bacilli of Urinary Tract Origin
The information collected will optimize the management of patients with urinary tract infections with secondary bacteremia, primarily with gram negative bacteria especially Escherichia coli.
- Conditions
- Urinary Tract Infection, Fluoroquinolone, Bacteremia
- Trial name
- NCT00414362
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Inflammation, Fungal Infection
Effect of Inflammation on Voriconazole Concentration
Voriconazole is a broad-spectrum antifungal agent. There is evidence for a relation between the efficacy and safety of voriconazole and voriconazole trough concentrations.
- Trial name
- NCT02074462
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
WOUNDS
Efficacy Study of Ultrasound-Assisted Debridement to Influence Wound Healing
The UltraHeal Study is a randomized controlled trial to compare healing response of low frequency contact ultrasonic-assisted debridement in addition to best practice wound care to best practice wound care alone in a Vascular…
- Trial name
- UltraHeal (NCT01973361)
- Testing
- Ultrasound debridement, Best practice wound care
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Sepsis
Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic.
Sepsis is an inflammation response produced by the host's immune system, which is agrravated by oxidative stress. One of the adjuvant therapy according to Surviving Sepsis Campaign Guideline is albumin, which has…
- Trial name
- NCT05596942
- Testing
- Albumin Channa Striata Extract
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Sebelas Maret
Sepsis, Infection
Plasma Neprilysin for Predicting Sepsis Within 48 Hours in ICU Patients With Infection or Suspected Infection
The goal of this multicenter prospective observational cohort study is to determine whether plasma neprilysin can predict the development of sepsis within 48 hours in adults admitted to an intensive care unit with confirmed or…
- Trial name
- NEPSIS (NCT07796386)
- Testing
- Plasma Neprilysin Measurement, Conventional Sepsis Biomarker Measurement, Sublingual Microcirculation Assessment
- Where
- 2 sites in China
- Volunteers
- 488 people
- Sponsor
- Zhujiang Hospital
Septic Shock
Adjuvant Therapy With CytoSorb in Refractory Septic Shock
This prospective randomized single center study investigates to what extent the removal of elevated cytokine levels by hemoadsorption has a positive effect on the treatment of patients in septic shock by stabilizing the…
- Trial name
- ACYSS (NCT04013269)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Post Abdominal Surgery, Sepsis Abdominal
Clinical Effects of Ringers Lactate Versus Sterofundin/ Plasmalyte Solution in Patients With Sepsis
The goal of this clinical trial is to compare the clinical effects of using Ringer's Lactate and Sterofundin/ Plasmalyte as maintenance fluids in adult patients who have undergone abdominal surgery and are septic.
- Trial name
- NCT07239713
- Testing
- Ringer's Lactate Crystalloid Solutions, Sterofundin (Bolus of crystalloids)
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Septic Shock, Severe Sepsis
Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact
Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis…
- Trial name
- SNA&Sepsis (NCT00835913)
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Septic Shock
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with…
- Trial name
- NCT00005890
- Testing
- corticotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Center for Research Resources (NCRR)
Infection, Sepsis
The 'Bekele Afessa Scan-Teach-Treat Approach'
Infection and sepsis are among the leading causes of death worldwide, particularly in middle- and low-income countries.The Surviving Sepsis Campaign has launched an initiative to improve sepsis care in resource-limited settings…
- Trial name
- NCT02697513
- Testing
- simple infection management protocol
- Volunteers
- 1,594 people
- Sponsor
- University of Salzburg
HIV Infections, AIDS
Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients
The purpose of this study is to evaluate the efficacy and safety of omega-3-fatty acids in HIV-infected patients with hypertriglyceridemia.
- Conditions
- HIV Infections, AIDS, Dyslipidemia, Hypertriglyceridemia
- Trial name
- NCT00346697
- Testing
- Omega-3 fatty acid administration
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Brown, Todd, M.D., Ph.D.
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Sepsis, Neonatal
Comparison Between Split Septum and Mechanical Valve Needleless Connector in Preterm Babies
The goal of this clinical trial study is to compare the effectiveness between split septum and mechanical valve needleless connector in very preterm babies (or under 1500 grams) The main questions it aims to answer are: What is…
- Trial name
- NCT06414174
- Testing
- Split septum needleless connector, Mechanical valve needleless connector
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Septic Shock
Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂
the investigators will include 120 patients with a diagnosis of septic shock in accordance with the definition given by the 2001 expert consensus.
- Trial name
- NCT03292120
- Testing
- measure of the SOFA score
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
COVID-19, Hypoxia
Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation
Previous research has shown that high dose intravenous vitamin C (HDIVC) may benefit patients with sepsis, acute lung injury (ALI), and the acute respiratory distress syndrome (ARDS).
- Trial name
- AVoCaDO (NCT04357782)
- Testing
- L-ascorbic acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
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