Clinical trials: Infection and Inflammatory Reaction
Diarrheal Diseases, Acute Respiratory Infections
Evaluation of Novel Antimicrobial Hand Towels
In March 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in Kisumu County, located in an area in western Kenya which has the highest under-five mortality rate in Kenya with 149…
- Conditions
- Diarrheal Diseases, Acute Respiratory Infections, Fever, Skin Infection
- Trial name
- NCT02512614
- Testing
- Antimicrobial Hand Towel
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Sepsis-related Myocarditis
Sepsis and Myocarditis
This prospective cohort study aims to investigate the cardiac manifestations of sepsis and their influence on disease outcomes among adult patients at Jimma University Medical Center, Ethiopia, from May 2025 to May 2026.
- Trial name
- NCT07079605
- Testing
- Standard treatment for sepsis of any focus, Treatment for the sepsis with standard management of cardiac failure
- Where
- Ethiopia
- Volunteers
- 226 people
- Sponsor
- Jimma University
Skin Diseases, Bacterial
Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections
The purpose of this study is to compare the safety and efficacy of the antibiotic tigecycline with other antibiotics, ampicillin-sulbactam, and amoxicillin-clavulanate in the treatment of a complicated skin and/or skin structure…
- Trial name
- NCT00368537
- Testing
- Tigecycline, ampicillin-sulbactam
- Where
- 57 sites in United States, Canada and 10 more
- Volunteers
- 550 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Severe Sepsis
Extravascular Lung Water Index in Severe Sepsis
To investigate whether extravascular lung water index (EVLI) is an independent predictor for multiorgan dysfunction syndrome (MODS) in patients with severe sepsis and to determine if increased EVLI may serve as an predictor for…
- Trial name
- EVLI in sepsis (NCT00986271)
- Testing
- EVLI was determinated by PiCCO plus system.
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Malaria,Falciparum, Malaria
Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
This is an open-label, adaptive study that will utilise the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile of pyronaridine.
- Conditions
- Malaria,Falciparum, Malaria, Malaria Recrudescence, Parasitemia
- Trial name
- NCT05287893
- Testing
- Pyronaridine, P. falciparum IBSM infection
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Inflammatory Rheumatism, Psoriatic Arthritis
Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?
TWEAK (TNF weakly inducer of apoptosis) is a type II-transmembrane protein, member of the TNF ligand superfamily that can be cleaved to function as a soluble cytokine.
- Conditions
- Inflammatory Rheumatism, Psoriatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02164214
- Testing
- etanercept Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Covid19
Vitamin D, Omega-3, and Combination Vitamins B, C and Zinc Supplementation for the Treatment and Prevention of COVID-19
The NUTROVID Factorial Trials The purpose of the NUTROVID-Prevent and NUTROVID-Treat Factorial Trials is to determine whether Vitamin B Complex, Vitamin C, and Zinc; Vitamin D; and Omega3, taken at dosages approximating…
- Trial name
- NUTROVID (NCT04828538)
- Testing
- Vitamin D, Omega DHA / EPA, Vitamin C, Vitamin B complex and Zinc Acetate
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital de la Soledad
Breast Neoplasms, Fever
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of thrombocytopenia and the time to recovery of…
- Conditions
- Breast Neoplasms, Fever, Hematologic Diseases, Neutropenia
- Trial name
- NCT00001338
- Testing
- FLAC chemotherapy with GM-CSF
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Bacteremia
Virulence Determinants in S Aureus Bacteremia
The purpose of this study is to investigate why some people develop life-threatening infections caused by the bacteria Staphylococcus aureus, while other people do not.
- Trial name
- NCT00319826
- Testing
- No intervention
- Where
- United States
- Volunteers
- 1,354 people, healthy volunteers welcome
- Sponsor
- Duke University
Diastolic Dysfunction, Septic Shock
Reversibility of Diastolic Disfunction in Septic Shock
Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality…
- Trial name
- REPRISS (NCT03198611)
- Testing
- Echocardiography
- Where
- 5 sites in Spain
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stellate Ganglion Block, Radial Artery Cannulation
Effect of Stellate Ganglion Block on Blood Flow in the Cannulated Radial Artery
To evaluate the value of US-guided Stellate ganglion block for improving radial arterial blood flow and peripheral perfusion in Septic shock patients on vasopressor support with an indwelling radial arterial cannula, which can…
- Trial name
- NCT03042663
- Testing
- USG stellate ganglion block
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Eslam Ayman Mohamed Shawki
Joint Prosthesis; Complications, Infection or Inflammation
Natural Course of Homocysteine After Uneventful Total Joint Arthroplasty
The goal of this observational study is to asses the natural course of blood homocysteine levels in patients who underwent primary total joint arthroplasty surgery.
- Trial name
- NCT05990816
- Testing
- Blood works for homocysteine levels
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Liver Abscess, Pyogenic, Liver Abscess
An Observational Study of Risk Factors and Long-term Prognosis of Patients With Liver Abscess in the "Real-world"
Pyogenic liver abscess is one of the most common visceral abscesses, its incidence is increasing worldwide. According to the previous literature, the mortality rate of pyogenic liver abscess is as high as 31% and become a serious…
- Conditions
- Liver Abscess, Pyogenic, Liver Abscess, Abscess, Infections
- Trial name
- NCT05213949
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Sepsis
Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring
Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation
- Trial name
- NCT03859726
- Testing
- NIRS, Sublingual microcirculation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xiangya Hospital of Central South University
Cellulitis
Sonographic Features of Cellulitis and Failure of Therapy
Skin and soft tissue infections represent a tremendous burden to the health care community with over 11.6 million ambulatory patients presenting annually in 2003 and 14.2 million in 2005.
- Trial name
- NCT01773499
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Massachusetts, Worcester
Sepsis, Critical Illness
FMT for 90-Day Outcome of Clinical Use in ICU Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, representing one of the leading causes of death in intensive care units (ICUs) worldwide.
- Conditions
- Sepsis, Critical Illness, Gastrointestinal Dysfunction, Dysbiosis
- Trial name
- FOCUS (NCT07670299)
- Testing
- Gut microbiota suspension
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Gingival Inflammation in Diabetic Patients
Herbal Periodontal Patch (THPP) for Gingival Inflammation in Diabetics
Diabetes increases the incidence and severity of periodontal inflammation and disease, and periodontal disease causes an increase in the severity of diabetes by worsening glycemic control and increasing insulin resistance.The…
- Trial name
- NCT00731432
- Testing
- Transmucosal Herbal Periodontal Patch (THPP)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Izun Pharma Ltd
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