Clinical trials: Infection and Inflammatory Reaction
Sepsis, Multiple Organ Dysfunction Syndrome
The Role of Angiopoietin, Tie-2, and Vascular Endothelial Growth Factor (VEGF) in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)
This study is designated to determine serum concentrations of inflammatory mediators Ang-1, Ang-2, Ang-1/Ang-2 ratio, and Tie-2 in patients with sepsis-induced MODS and to investigate the association among increased permeability…
- Trial name
- NCT00908635
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Cystic Fibrosis, Allergic Bronchopulmonary Aspergillosis
Mechanisms of Immune Tolerance and Inflammation in Patients With Cystic Fibrosis With ABPA
The goal of this study is to identify the immunological factors that influence a patient's response to the presence of the fungus Aspergillus fumigatus (A. fumigatus) in the lungs.
- Trial name
- ABPA (NCT00585364)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Acute Respiratory Tract Infection, Acute Respiratory Insufficiency
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical…
- Conditions
- Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia, Septic Shock
- Trial name
- NCT04346693
- Testing
- Standard therapy recommended by the Ministry of Health of the Russian Federation., Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection, Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Septic Shock
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients.
- Trial name
- NCT04282252
- Testing
- I.V. SOLUTIONS
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Karolinska Institutet
Sepsis
TRIM25 in Septic Patients
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure.
- Trial name
- NCT07320638
- Testing
- Gene and Inflammatory Marker Analysis in Sepsis
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Long COVID
Study of LAU-7b for the Treatment of Long COVID in Adults
ESSOR is a double-blind, placebo-controlled study of the orally-administered antiviral and inflammation-controlling LAU-7b for the treatment of adults with Long COVID and moderate to severe symptoms.
- Trial name
- ESSOR (NCT05999435)
- Testing
- LAU-7b for 3 cycles
- Where
- 5 sites in Canada
- Volunteers
- 272 people
- Sponsor
- Laurent Pharmaceuticals Inc.
Human Immunodeficiency Virus (HIV)
The Effects of Chiropractic Care on Inflammation and Quality of Life in People Living With HIV
The main aim of this pilot trial is to investigate the feasibility of undertaking a randomized controlled trial involving adults living with HIV.
- Trial name
- HIV (NCT07466836)
- Testing
- Chiropractic Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tyson Perez, DC, PhD
Pneumonia, Viral, Influenza in Humans
Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu
The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is rapidly progressing worldwide and a substantial number of patients get severe H1N1 related pneumonia that requires mechanical ventilation…
- Trial name
- CORTIFLU (NCT01014364)
- Testing
- hydrocortisone, isotonic saline
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University of Versailles
Anemia, Sepsis
Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial
Background Up to 66% of have anemia at the admission to the intensive care unit. This number increases to 95% after 72 hours of hospitalization in the intensive care unit due to illness and iatrogenic blood loss.
- Conditions
- Anemia, Sepsis, Septic Shock
- Trial name
- EpoAid (NCT06670963)
- Testing
- Iron, EPO, 0.9 % NaCl
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Piotr Czempik
Septic Shock
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock
The purpose of this study is : to evaluate the hemodynamic tolerance of esmolol titrated to obtain a lowering of heart rate of 10% or 20%.
- Trial name
- THANE (NCT02120404)
- Testing
- Esmolol administration
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill, Acute Kidney Injury
Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Compared with AN69 hemofilter, AN69 ST hemofilter may prolong the time of hemofilter and decrease the quantity of heparin during continuous renal replacement therapy in critically ill.
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- NCT01823484
- Testing
- AN 69 ST hemofilter, AN 69 hemofilter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Staphylococcus Aureus, Bacteremia
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens.
- Trial name
- NCT01352936
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Taipei Medical University WanFang Hospital
Septic Shock
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure
The purpose of this trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in up to a total of 380 patients with septic shock suffering from…
- Trial name
- COMBAT-SHINE (NCT04123444)
- Testing
- Iloprost, Isotonic saline
- Where
- 6 sites in Denmark
- Volunteers
- 279 people
- Sponsor
- Jakob Stensballe, MD, PhD
Septic Shock
Euthyroid Sick Syndrome in Septic Shock
This prospective observational cohort study included all septic shock patients with two groups of ESS and anylised in 28-day outcome, clinical biochemical parameters and hemodynamic monitoring.
- Trial name
- NCT06242626
- Testing
- observation
- Where
- Bosnia and Herzegovina
- Volunteers
- 47 people
- Sponsor
- Cantonal Hospital Zenica
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Endotoxemia
Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- VIHE (NCT01100996)
- Testing
- control enteral nutrition, enriched enteral feeding
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteremia
Detecting Infections Rapidly and Easily for Bacteremia Trial (DIREBT)
To assure the uniform collection, handling, storage and transport of patient whole blood specimens and associated information to support validation of the T2 Bacteremia Assay.
- Trial name
- DIREBT (NCT01919762)
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- T2 Biosystems
Neonatal Sepsis
Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis
The present study was designed to evaluate the effectiveness of oral lactoferrin in prevention of neonatal sepsis with comparison early (1st day) versus late (48-72 hours) Lactoferrin administration, Secondary aim was to study…
- Trial name
- NCT02959229
- Testing
- Lactoferrin
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sepsis, Acute Kidney Injury
Prognostic Interest of Vasorin in Septic Shock
In septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe Acute Kidney Injury (AKI).
- Trial name
- VASO-SHOCK (NCT06072508)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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