Clinical trials: Infectious Respiratory Diseases
COVID-19
Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers
Since December 2019, the emergence of a new coronavirus named SARS-Cov-2 in the city of Wuhan in China has been responsible for a major epidemic of respiratory infections, including severe pneumonia.
- Trial name
- COVIDAXIS (NCT04328285)
- Testing
- Hydroxychloroquine, Lopinavir and ritonavir
- Where
- 9 sites in France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypoxemia, Hypercapnia
Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements
Background Intermittent Positive Pressure Ventilation is used during general anesthesia but can lead to serious complications. Respiratory parameter settings can be adjusted to minimize the detrimental effects of this…
- Conditions
- Hypoxemia, Hypercapnia, Ventilator Associated Pneumonia, Complication of Anesthesia
- Trial name
- OPTIMVSPRIME (NCT06298435)
- Testing
- Intermittent Positive pressure ventilation
- Where
- Netherlands
- Volunteers
- 20,000 people
- Sponsor
- University Medical Center Groningen
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
SARS-CoV-2 Infection, COVID-19
To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age.
Substudy A: The study will evaluate the safety, tolerability, and efficacy of a booster dose of BNT162b2 when administered to participants having previously received 2 doses of BNT162b2 at least 6 months prior to randomization.
- Trial name
- NCT04955626
- Testing
- BNT162b2, BNT162b2 OMI, Combination BNT162b2 and BNT162b2 OMI
- Where
- 154 sites in United States, Brazil and 3 more
- Volunteers
- 16,372 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
COVID, Corona Virus Infection
Efficacy and Safety of Novel Treatment Options for Adults With COVID-19 Pneumonia
CCAP is an investigator-initiated multicentre, randomized, double blinded, placebo-controlled trial, which aims to assess the safety and efficacy of treatment with convalescent plasma for patients with moderate-severe COVID-19.
- Conditions
- COVID, Corona Virus Infection, Viral Pneumonia
- Trial name
- CCAP (NCT04345289)
- Testing
- Convalescent anti-SARS-CoV-2 plasma
- Where
- 12 sites in Denmark
- Volunteers
- 147 people
- Sponsor
- Thomas Benfield
Infection Viral
COVID-19 Biological Samples Collection
The coronavirus disease 2019 (COVID-19) outbreak is now considered as a public health emergency of international concern by the World Health Organization.
- Trial name
- COLCOV19-BX (NCT04332016)
- Testing
- biological samples collection
- Where
- France
- Volunteers
- 615 people
- Sponsor
- University Hospital, Bordeaux
COVID-19 Pandemic, ICU
Chronic Pain in COVID-19 Patients Discharged From Intensive Care Unit
More than six million French were affected by SARS-COV2 epidemic. About 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (ICU) for severe SARS-COV2 acute respiratory distress…
- Conditions
- COVID-19 Pandemic, ICU, Pain, Chronic, Post Intensive Care Unit Syndrome
- Trial name
- NCT04940208
- Testing
- Pain and neuropsychological questionnaires, Quantitative Sensory testing
- Where
- 3 sites in France
- Volunteers
- 143 people
- Sponsor
- Mikhail Dziadzko, MD, PhD
COVID-19, Sars-CoV-2 Infection
Phase 3 Booster Vaccination Against COVID-19
The inactivated Booster Phase 3 study aims to determine the efficacy, safety, and immunogenicity of inactivated COVID-19 vaccines in subjects with a minimum of 90 days and a maximum of 270 days after the second dose of CoronaVac…
- Trial name
- NCT05077176
- Testing
- CoronaVac, Turkovac
- Where
- 41 sites in Turkey (Türkiye)
- Volunteers
- 4,340 people, healthy volunteers welcome
- Sponsor
- Health Institutes of Turkey
COVID-19
Phase I-II Trial of Dendritic Cell Vaccine to Prevent COVID-19 in Adults
This is an adaptive Phase I-II trial of a vaccine consisting of autologous dendritic cells previously loaded ex vivo with SARS-CoV-2 spike protein, with or without GM-CSF, to prevent COVID-19 in adults.
- Trial name
- NCT04386252
- Testing
- AV-COVID-19
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aivita Biomedical, Inc.
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in pediatric patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated severe or life-threatening…
- Trial name
- NCT00002317
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- U.S. Bioscience
COVID-19 Respiratory Infection
Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome
Our hypothesis - that 21 days of mountain spa rehabilitation with ubiquinol supplementation could to accelerate regeneration of patients with post-COVID-19 syndrome, based on the improving platelet mitochondrial bioenergetic…
- Trial name
- SpaCOVID (NCT05178225)
- Testing
- ubiquinol (reduced coenzyme Q10), mountain spa rehabilitation, 2x14 ml of peripheral blood collected in a tube with anticoagulant
- Where
- Slovakia
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Comenius University
Covid19
Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection
This is a 2-part, 2-arm, Phase 2 , multicentre, randomized, double-blind, placebo-controlled study in adults with COVID-19 with gastrointestinal infection.
- Trial name
- RESERVOIR (NCT04858425)
- Testing
- Niclosamide
- Where
- 25 sites in United States, India and 1 more
- Volunteers
- 166 people
- Sponsor
- Entero Therapeutics
COVID, ARDS
Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS
Prone position (PP) has been proved to be effective in severe ARDS patients. On the other hand, High flow nasal cannula (HFNC) may prevent intubation in hypoxemic Acute respiratory failure (ARF) patients.
- Conditions
- COVID, ARDS, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04391140
- Testing
- Prone position
- Where
- Spain
- Volunteers
- 248 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Respiratory Infection, Diarrheal Disease
Efficacy and Tolerance of a Follow-On Formula Fed to Children From 36-48 Months of Age
The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.
- Trial name
- NCT01488435
- Testing
- Cow's milk, Follow-On Formula
- Where
- China
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Common Cold
Experimental Human Rhinovirus Infection
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time points for experimental HRV…
- Trial name
- EHRVI (NCT01823640)
- Testing
- Human Rhinovirus strain 16 (HRV-16)
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
SARS CoV 2 Infection
Recovering From COVID-19
Following the success of pilot data trialling a virtual community-based remote monitoring model, using Bluetooth enabled pulse oximeters, which demonstrated a saving of 300 bed spaces over a three week period,9 a nationwide…
- Trial name
- OVER-COVID (NCT05302960)
- Testing
- Fitbit
- Sponsor
- Imperial College London
Respiratory Infection
Effect of IN Hospital PCR Based Assessment of Patients With Lower Respiratory Tract Infections on LEngth of Stay
Does the use of the BIOFIRE® FILMARRAY® Pneumonia Panel plus in hospitalized patients with lower respiratory infections lead to a reduction in length of hospital stay (LOS) and customized antibiotic treatment (higher amount of…
- Trial name
- INHALE (NCT05904223)
- Testing
- Respiratory Panel PCR Sputum
- Where
- Austria
- Volunteers
- 302 people
- Sponsor
- Alexander Zoufaly
Bronchiolitis, Bronchiolitis, Viral
Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis
This study will compare the novel methods of NS and BS with the standard technique of nasophayngeal aspiration (NPA) and routine ETT suction.
- Conditions
- Bronchiolitis, Bronchiolitis, Viral, RSV Infection, Respiratory Failure
- Trial name
- RSV-SAM (NCT03062917)
- Testing
- Nasal and Bronchial Sampling
- Where
- United Kingdom
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Respiratory Tract Infections, Bronchiolitis Obliterans
Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant
For many patients with blood cancers, stem cell transplantation from a family member or from an unrelated donor remains the only potentially curative option.
- Conditions
- Respiratory Tract Infections, Bronchiolitis Obliterans, Cryptogenic Organizing Pneumonia, Lung Diseases, Interstitial
- Trial name
- NCT01432080
- Testing
- Prednisone, Azithromycin, Montelukast
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Maisonneuve-Rosemont Hospital
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