Clinical trials: Infectious Respiratory Diseases
Lower Respiratory Tract Infection, Acute Bronchitis
Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
The purpose of this study is to validate the diagnostic accuracy of a novel host-response based diagnostic tool for differentiating between bacterial and viral etiologies in adult patients aged 18 years and older with clinical…
- Conditions
- Lower Respiratory Tract Infection, Acute Bronchitis, Pneumonia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OBSERVER (NCT03011515)
- Where
- Israel
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Ventilator Associated Pneumonia, Tracheobronchitis
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship…
- Trial name
- BrighT STAR (NCT04987840)
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Bronchiectasis, Lower Respiratory Infection
Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
To test whether POL7080 is effective in patients with exacerbation of non-cystic fibrosis bronchiectasis caused by Pseudomonas aeruginosa infection.
- Trial name
- NCT02096315
- Testing
- POL7080
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Polyphor Ltd.
Diabetes, Covid-19
Remote Continues Glucose Monitoring During the COVID-19 Pandemic in Quarantined Hospitalized Patients
This is a randomized controlled trial of isolated patients with diabetes admitted to Nordsjællands Hospital with or without COVID-19-pneumonia.
- Conditions
- Diabetes, Covid-19, Infection
- Trial name
- CGM-ISO (NCT04430608)
- Testing
- Dexcom G6
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Nordsjaellands Hospital
COVID-19 Infection
DISmantling COvid iNduced Neutrophil ExtraCellular Traps (DISCONNECT-1)
This is a pilot study to investigate the safety and feasibility of rhDNase1 and its impact on neutrophil extracellular traps (NETs) in COVID-19 infected patients.
- Trial name
- DISCONNECT-1 (NCT04409925)
- Testing
- rhDNase I
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
SARS-CoV-2, COVID-19
A Cohort of Patients With Possible or Confirmed SARS-CoV-2 (COVID-19)
SARV-CoV-2 infection was considered pandemic on March 11, 2020. The SARV-CoV-2 epidemic affected France from the beginning of March, spreading in particular from a 4-day large evangelical meeting of 2500 people on February 17 in…
- Trial name
- COVIDothèque (NCT04347850)
- Testing
- blood sample
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
COPD, Diabetes
Effectiveness of Physical Exercise of Patients With Chronic Non-communicable Disease
According to the Pan American Health Organization (PAHO), chronic, non-communicable diseases (NCDs) are the main cause of death and disability in the world.
- Conditions
- COPD, Diabetes, Physical Inactivity, Frailty
- Trial name
- NCT06476015
- Testing
- Therapeutic exercise
- Where
- Colombia
- Volunteers
- 300 people
- Sponsor
- Fundacion Universitaria Maria Cano
Coronavirus Disease-2019 (COVID-19)
Efficacy and Safety of TY027, a Treatment for COVID-19, in Humans
The emergence \& rapid spread of the coronavirus disease 2019 (COVID-19) since December 2019 across 188 countries globally has become a major public health crisis.
- Trial name
- NCT04649515
- Testing
- TY027, 0.9% saline
- Where
- Singapore
- Volunteers
- 17 people
- Sponsor
- Tychan Pte Ltd.
SARS-CoV-2 Infection
Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19
The study investigates whether patients with mild SARS-CoV-2 infection, who stayed at home during their infection and weren't hospitalized, have any persisting sequelae in pulmonary function.
- Trial name
- NCT06318208
- Testing
- lung function testing
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University of Rostock
Pneumonia, Pneumonia in Children
Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia
The main questions this study aims to answer are: Does using probiotic nasal spray (LiveSpo Navax containing Bacillus subtilis and Bacillus clausii, 1x10^9 CFU/mL), with or without oral probiotics (LiveSpo Pregmom containing…
- Trial name
- NCT07399717
- Testing
- Navax, Navax-PregMom
- Where
- Vietnam
- Volunteers
- 330 people
- Sponsor
- Anabio R&D
Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV)
Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in the voice box, windpipe, or lungs.
- Conditions
- Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV), Papillomavirus Infection, Laryngeal Diseases
- Trial name
- NCT07756840
- Testing
- PRGN-2012, Bevacizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Pneumonia, Ventilator-Associated, Stenotrophomonas Infection
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs
Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or…
- Conditions
- Pneumonia, Ventilator-Associated, Stenotrophomonas Infection, Critical Illness, Pneumonia, Bacterial
- Trial name
- RETROSTENO (NCT03506191)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Maternal Death, Maternal Infections Affecting Fetus or Newborn
Azithromycin-Prevention in Labor Use Study (A-PLUS)
Maternal and neonatal infections are among the most frequent causes of maternal and neonatal deaths, and current antibiotic strategies have not been effective in preventing many of these deaths.
- Conditions
- Maternal Death, Maternal Infections Affecting Fetus or Newborn, Neonatal SEPSIS, Maternal Sepsis During Labor
- Trial name
- NCT03871491
- Testing
- Azithromycin
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 5 more
- Volunteers
- 58,747 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Bronchiectasis, Fungal Infection of Upper Respiratory Tract
Itraconazole Therapy In Bronchiectasis With Airway Mold
The primary objective of this study is to evaluate the feasibility of itraconazole therapy in patients with bronchiectasis and airway mold.
- Trial name
- NCT07283497
- Testing
- Itraconazole 200 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Recurrent Respiratory Papillomatosis, Papillomavirus Infection
Zopa Retreatment and Vector Shedding in Adults With RRP
This open-label study evaluates safety, vector shedding, and retreatment efficacy of Zopapogene imadenovec (Zopa) in adults with recurrent respiratory papillomatosis (RRP).
- Conditions
- Recurrent Respiratory Papillomatosis, Papillomavirus Infection, Papillomaviridae
- Trial name
- NCT06538480
- Testing
- Zopapogene imadenovec (Zopa)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Precigen, Inc
Coronavirus Infection COVID-19
Clinical Trial of a Medical Device "Device for Non-invasive Electromagnetic Therapy "TOR" in the Treatment of COVID-19"
A clinical trial was conducted with human participation in order to assess the safety and efficacy of the medical device "TOR device for non-invasive electromagnetic therapy" when used as an adjunct in combination with standard…
- Trial name
- NCT05220579
- Testing
- Exposure to "TOR" device, Exposure to switched off "TOR" device
- Where
- Russia
- Volunteers
- 236 people
- Sponsor
- Concern GRANIT
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