Clinical trials: Infectious Respiratory Diseases
Bacterial Infection
Bacterial Pulmonary Infection in PICU
The purpose of this study is to develop a scoring system to allow doctors to accurately identify children on a mechanical ventilator who have bacterial pneumonia.
- Trial name
- NCT00271531
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Infection, Sars-cov-2
Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection
The current sars-cov-2 epidemic is responsible for severe respiratory infections leading to end-of-life situations. Dexmedetomidine may be indicated in mild to moderate sedation in palliative patients, due to its pharmacological…
- Conditions
- COVID-19 Infection, Sars-cov-2, Respiratory Failure, Palliative Situation
- Trial name
- PRODEX (NCT04350086)
- Testing
- Treatment with Dexmedetomidine
- Where
- France
- Sponsor
- University Hospital, Limoges
SARS-CoV-2
Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (BNT162b2) in Chinese Healthy Population
This was a phase II, randomized, placebo-controlled, observer-blinded study of the safety and immunogenicity of SARS-CoV-2 messenger RNA (mRNA) vaccine (BNT162b2) in Chinese healthy population.
- Trial name
- NCT04649021
- Testing
- BNT162b2
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Pregnancy
Prevalence and Impact of COVID-19 Infection in Pregnant Women, Fetuses and Newborns
A novel human coronavirus, named SevereAcute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), emerged in China, in late 2019, and is now spreading quickly causing a pandemic.
- Trial name
- COVIPREG (NCT04355234)
- Testing
- identify SARS-CoV-2 infection by serology, collection of biological samples
- Where
- France
- Volunteers
- 2,446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Acute COVID19 Syndrome, COVID-19
FMT for Post-acute COVID-19 Syndrome
In recovered COVID-19 patients, emerging global data have reported the presence of long COVID, that is, at least one symptom that an alternative diagnosis cannot explain has been persistent for four or more weeks after the…
- Trial name
- FMT-PACS (NCT05556733)
- Testing
- Faecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
SARS-CoV-2 Infection, Covid19
Prospective COVID-19 Cohort Study, Dominican Republic
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health…
- Trial name
- NCT04898738
- Testing
- Alcohol based hand sanitizer
- Where
- Dominican Republic
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Post-Acute COVID-19 Syndrome, Long COVID
QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG
The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians.
- Conditions
- Post-Acute COVID-19 Syndrome, Long COVID, Brain Fog
- Trial name
- QEEG-NFT (NCT07005921)
- Testing
- qEEG-neurofeedback
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jade Carvalho Da Silva
Severe Pneumonia, Biomarkers
Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis
The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.
- Trial name
- NCT06533514
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Hepatitis B, ESRD (End Stage Renal Disease)
Comparing Hepatitis B Vaccination Schedules in Patients on Hemodialysis
People with kidney failure who are on dialysis have a weaker immune response to the hepatitis B vaccine than healthy people. Even after vaccination, many dialysis patients do not develop enough protection against hepatitis B…
- Conditions
- Hepatitis B, ESRD (End Stage Renal Disease), Kidney Failure, Chronic
- Trial name
- 3v4-HEP-DOSE (NCT07784452)
- Testing
- Recombinant Hepatitis B Vaccine - 3-Dose Schedule, Recombinant Hepatitis B Vaccine - 4-Dose Schedule
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Jinnah Hospital
COVID-19 Respiratory Infection
Oral Symptoms of COVID-19 Among Infected Medical Doctors
Oral symptoms of corona virus disease have been reported by many studies. The lack of direct contact between the dentist and the patient during the active disease presented an obstacle to build a strong body of evidence.
- Trial name
- NCT05697081
- Testing
- Medical doctors infected with COVID-19
- Where
- Egypt
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Otitis Media, Urinary Tract Infection
ParentLink: Better and Safer Emergency Care for Children
The emergency department (ED) constitutes a high-risk environment for errors and poor quality of care. Pediatric patients are at increased risk of medical errors.
- Conditions
- Otitis Media, Urinary Tract Infection, Asthma, Head Injury
- Trial name
- NCT00457600
- Testing
- patient-driven health IT product
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Boston Children's Hospital
Malignant Hematological Diseases
Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
The occurrence of bronchiolitis obliterans syndrome (SBO) after allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be a chronic pulmonary graft versus host disease (GVHD) that is associated with…
- Trial name
- ALLOZITHRO (NCT01959100)
- Testing
- Azithromycin
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection
LEAP-CT for Treatment of COVID-19 Patients (Master Protocol)
This master protocol serves as a common reference for the inpatient and outpatient clinical studies that share common elements.
- Conditions
- 2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection, 2019-nCoV Disease, 2019-nCoV Infection
- Trial name
- NCT05077332
- Testing
- Famotidine, Celecoxib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Leidos Life Sciences
HIV Infections
A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP
To examine the dose of zidovudine (AZT) that was used in the first placebo-controlled study of AZT in AIDS patients as well as a lower dose of AZT in order to determine if the lower dose results in less harmful side effects while…
- Trial name
- NCT00000700
- Testing
- Zidovudine
- Where
- 28 sites in United States
- Volunteers
- 482 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Acute Respiratory Distress Syndrome
Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)
This study plans to learn more about the effects of Dornase Alfa in COVID19 (coronavirus disease of 2019) patients, the medical condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Trial name
- COVIDORNASE (NCT04355364)
- Testing
- Dornase Alfa Inhalation Solution [Pulmozyme], standard procedure
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Liver Transplant Infection, Covid19
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients
This is a prospective study analyzing the development of humoral immune response against SARS-Cov-2 in patients with previous Covid19: the aim is to compare the incidence, titration and evolution of IgG an IgM in a prospective…
- Conditions
- Liver Transplant Infection, Covid19, Mortality, Immune Response
- Trial name
- NCT04410471
- Testing
- CLIA of IgG and IgM against SARS-Cov-2
- Where
- 2 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Magdalena Salcedo
Long COVID, Brain Fog
Long COVID Brain Fog: Cognitive Rehabilitation Trial
This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment.
- Conditions
- Long COVID, Brain Fog, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT06095297
- Testing
- Processing Speed Training, In-lab Instrumental Activities of Daily Living Training, In-lab Brain Health Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Covid19
Genetic Predisposition to Severe Forms of COVID-19 (SARS-CoV2 Infection)
The main objective of this part of the project is to identify the germline genetic factors which discriminate the benign and severe forms of SARS-CoV2 (CoVID-19) infection in the context of the ongoing SARS-CoV2 (HCOVID-19)…
- Trial name
- COVIDGEN (NCT04644146)
- Testing
- GENETIC
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Virus Diseases, RNA Virus Infections
Immunogenicity, Safety, Tolerability of a Plant-made H5 Virus-like-particle (VLP) Influenza Vaccine.
A phase 2, Randomized, Observer-blind, Multicenter, Dose-Ranging Study to Evaluate the Immunogenicity, Safety, and Tolerability of the plant-made H5 VLP Influenza vaccine adjuvanted with Alhydrogel or Glucopyranosyl-lipid…
- Conditions
- Virus Diseases, RNA Virus Infections, Respiratory Tract Diseases, Respiratory Tract Infections
- Trial name
- NCT01991561
- Testing
- Low dose of H5 VLP vaccine + Alhydrogel, Med dose of H5 VLP vaccine + Alhydrogel, High dose of H5 VLP vaccine + Alhydrogel
- Where
- 2 sites in Canada
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Medicago
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