Clinical trials: Infertility,Female
Infertility, Female
SCLife®-UT hUC-MSCs Advanced Therapy Medicinal Products (hUC-MSCs ATMPs) for Patients With Thin Endometrial Infertility
To explore the therapeutic effect and safety of human umbilical cord mesenchymal stem cells on thin endometrial infertility and to explore whether human umbilical cord mesenchymal stem cells using collagen as the carrier can…
- Trial name
- NCT06503471
- Testing
- human umbilical cord mesenchymal stem cell complex collagen, intrauterine injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Female Infertility, NF-κB Ligand
Clinical Relevance of Modifying RANKL Signaling During Folliculogenesis
Female infertility presents a significant societal challenge that will be aggravated in the future due to delayed parenthood. Our translational research suggests that receptor activator of NF-κB ligand (RANKL) is a novel…
- Conditions
- Female Infertility, NF-κB Ligand, RANKL, Osteoporosis
- Trial name
- NCT07546552
- Testing
- Denosumab, PBS
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
Infertility, Infertility, Female
Attention to Variability During Infertility
Infertility affects approximately one in seven couples, and it can be a devastating diagnosis and difficult experience for couples to endure.
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- NCT03712982
- Testing
- Attention to Variability - Patient Only, Attention to Variability - Partner Only, Attention to Variability - Patient & Partner
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Harvard University
IVF Patients, Female Infertility
Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment
The success rate after treatment by in-vitro fertilisation (IVF) strongly depends on the endometrial receptivity, which in turn is strictly connected to the endometrial immune profile.
- Trial name
- NCT07535190
- Testing
- Platelet rich plasma (PRP)
- Where
- Bulgaria
- Volunteers
- 50 people
- Sponsor
- Nadezhda Women's Health Hospital
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Fertility Disorders, Psychological Stress
Strategies for Pregnancy Achievement
The purpose of pilot study application is to build on the investigators' previous work that established the prospective association between stress and infertility.
- Conditions
- Fertility Disorders, Psychological Stress, Infertility, Infertility, Female
- Trial name
- SPA (NCT03085212)
- Testing
- Stress Free Now
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Courtney D.Lynch, PhD MPH
Infertility (IVF Patients), Infertility Female
Norethindrone Impact on Receptiva Outcomes
This retrospective study aims to evaluate pregnancy outcomes in patients with a positive BCL6 test (ReceptivaDx, who were treated with either norethindrone acetate or Depo Lupron prior to embryo transfer.
- Trial name
- NIRO (NCT07134920)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Female
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
This randomized controlled trial aims to determine whether Erzhi Tiangui Formula can optimize the reproductive outcomes of elderly patients with expected poor ovarian response, and to provide a new approach to traditional Chinese…
- Trial name
- NCT05698550
- Testing
- Erzhi Tiangui Granule
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Female Infertility
Magnetic Resonance Imaging (MRI) Hysterosalpingography Versus Radiographic Hysterosalpingography in Female Infertility
The main objective of this study is to compare the data of Hystérosalpingo-MRI with intra cavitary injection of diluted gadolinium salts with the classic hysterography, which allows to realize at once with no irradiating…
- Trial name
- NCT02108665
- Testing
- Radiographic hysterosalpingography, Magnetic resonance imaging hysterosalpingography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Infertility, Female
Deferred Versus Fresh Embryo Transfers
Controlled ovarian stimulation (COS) enhances the efficacy of ART (Assisted reproductive technology) by permitting multiple-oocyte yields, but also alters endometrial receptivity (ER) by an advancement of endometrial development…
- Trial name
- DEFETOSE (NCT03349905)
- Testing
- fresh transfer, Deferred-frozen embryo transfer
- Where
- France
- Volunteers
- 237 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
IVF, Infertility, Female
Effect of Tadalafil on Endometrial Thickness and Frozen Embryo Transfer Outcomes
investigate the effect of different vasodilators as Tadalafil in women with unexplained infertility using IVF
- Trial name
- NCT07499804
- Testing
- Tadalafil 5mg, estradiol valerate 2 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Infertility, Female
Impact of a Mindfulness Intervention on Infertile Women Undergoing Assisted Reproductive Technique Treatments
Infertility and its treatments can have a significant impact on women's psychological health. Anxiety has a negative impact on quality of life during treatment and can lead to withdrawal of care.
- Trial name
- EMOT-IVF (NCT04419740)
- Testing
- Mindfulness based psychological intervention
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cervical Mucus Dysfunction, Infertility, Female
Identification of Biomarkers in Cervical Mucus
Cervical mucus is a biological fluid secreted by the endocervical glandular epithelium whose quantitative and qualitative characteristics vary in response to the hormonal stimulus produced by the ovary during the woman's…
- Trial name
- IBISCUS (NCT06771401)
- Testing
- cervical mucus sampling
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infertility, Female
A Study of HS-10518 in Healthy Adult Premenopausal Females in China
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HS-10518 in healthy adult premenopausal females in China
- Trial name
- NCT07264192
- Testing
- HS-10518
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Deep Endometriosis, Infertility, Female
Impact of Operation on Fertility for Women With Severe Endometriosis
The EFFORT study compares the impact on fertility of operation or fertility treatment (IVF, in vitro fertilization) in a multicenter randomized controlled trial.
- Trial name
- EFFORT (NCT04610710)
- Testing
- Operation, Fertility treatment
- Where
- 3 sites in Denmark, France
- Volunteers
- 38 people
- Sponsor
- Horsens Hospital
Infertility, Female
Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET
The purpose of this study is to investigate whether oral Gushen Antai pills supplementation for luteal phase support will improve ongoing pregnancy rate in women with normal ovarian reserve in fresh embryo transfer cycles.
- Trial name
- GSATP-FreET (NCT04872660)
- Testing
- Gushen Antai Pill
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility, Female
Association Between Serum Thyroid-stimulating Hormone (TSH) and Intracytoplasmic Sperm Injection (ICSI) Outcome in Women Undergoing ICSI
TSH has been suggested to be involved in reproductive challenges such as ovulatory issues, infertility, miscarriage, and maternal complications for many years.
- Trial name
- NCT07449260
- Testing
- Basal TSH level
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility, Female
Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients
This retrospective study included 1,831 single blastocyst frozen embryo transfer (FET) cycles performed between November 1, 2022 and August 31, 2025.
- Trial name
- NATEC (NCT07450300)
- Testing
- Modified natural cycle, Substitued cycle, Hormonal replacement therapy
- Where
- France
- Volunteers
- 1,831 people
- Sponsor
- Clinique Mathilde