Clinical trials: Infertility,Female
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Female
Improving Reproductive Fitness Through Pretreatment With Lifestyle Modification in Obese Women With Unexplained Infertility
A two-arm, multicenter, prospective, randomized clinical trial of a lifestyle modification program with tracked increased physical activity and weight loss (intensive) compared to recommendations to tracking of increased physical…
- Trial name
- FIT-PLESE (NCT02432209)
- Testing
- Caloric Restriction, Orlistat, Moderate physical activity
- Where
- 10 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
Mood
Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation
Clomiphene citrate is commonly used for ovulation induction in women with anovulation, correction of luteal phase deficiency or for superovulation as empiric therapy for unexplained infertility.
- Trial name
- NCT01291056
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Infertility, Endometriosis
The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.
In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy.
- Trial name
- NCT01682642
- Testing
- Zoladex
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Anovulation
Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction
The purpose of this study is to investigate and compare the safety and efficacy of various doses of the aromatase inhibitor (anastrozole) versus clomiphene citrate in stimulating follicular growth and ovulation in infertile women…
- Trial name
- NCT00213148
- Testing
- Anastrozole 1 mg, Anastrozole 5 mg, Anastrozole 10 mg
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- EMD Serono
Infertility
A Randomised Trial Using Highly Purified Human Chorionic Gonadotropin (HP-hCG) and Recombinant Human Chorionic Gonadotropin (rhCG) in Women Undergoing Controlled Ovarian Stimulation
This trial is investigating the efficacy and safety of highly purified human chorionic gonadotropin (HP-hCG) and recombinant human chorionic gonadotropin (rhCG) for triggering of final follicular maturation in women undergoing…
- Trial name
- FASHION (NCT02449889)
- Testing
- highly purified human chorionic gonadotropin, recombinant human chorionic gonadotropin
- Where
- Brazil
- Volunteers
- 176 people
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome, Infertility
Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)
Progestin-induced endometrial shedding (PIES) followed by clomiphene citrate is fertility treatment of choice in anovulatory women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT01718444
- Testing
- Progestin, Clomiphene Citrate
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois Chicago
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Endometriosis, Infertility
Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF
This prospective randomized trial evaluates whether one can predict which infertile women with endometriosis who are candidates for in vitro fertilization will benefit from prolonged therapy with a GnRH agonist by the…
- Trial name
- IntegrinIVF (NCT00621179)
- Testing
- Leuprolide acetate in depot suspension, No intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Colorado Center for Reproductive Medicine
Endometriosis, Unexplained Infertility
Elagolix for Fertility Enhancement Clinical Trial
Studies suggest that undiagnosed endometriosis results in poor reproductive outcomes in the setting of In Vitro Fertilization and Embryo Transfer (IVF-ET).
- Trial name
- EFFECT (NCT04039204)
- Testing
- Elagolix, Ortho Cyclen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Uterine Fibroids, With Unexplained Infertility
ExAblate Treatment of Uterine Fibroids for Fertility Enhancement
The objective of this trial is to evaluate the efficacy and safety of the ExAblate 2000 system for enhancement of fertility in women with non-hysteroscopically resectable uterine fibroids, who are diagnosed with unexplained…
- Trial name
- NCT00730886
- Testing
- ExAblate 2000, Myomectomy
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- InSightec
Infertility
A Dose-response Trial Using rFSH FE 999049 in Women Undergoing IVF/ICSI Treatment
This trial investigates the effects of several doses of FE 999049 in women undergoing IVF/ICSI (in-vitro fertilisation/intracytoplasmic sperm injection) treatment.
- Trial name
- NCT01426386
- Testing
- FE 999049, Gonal - F
- Where
- 8 sites in Belgium, Czechia and 2 more
- Volunteers
- 265 people
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome, PCOS
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
This study evaluates the addition of clomiphene citrate (CC) to letrozole for the treatment of infertility in women with polycystic ovary syndrome across a course of two treatment cycles with stair step dosing of letrozole…
- Conditions
- Polycystic Ovary Syndrome, PCOS, Infertility
- Trial name
- CLC II (NCT05206448)
- Testing
- Letrozole, Clomiphene Citrate
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- Rachel Mejia
Polycystic Ovary Syndrome
Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women
The goal of this three-armed randomized controlled trial is to establish the relative roles of treatment of hyperandrogenism versus obesity (as the largest modifiable factor contributing to insulin resistance) in treating…
- Trial name
- OWL-PCOS (NCT00704912)
- Testing
- Orlistat/Meal Replacement/Lifestyle Modification, Loestrin 1/20, Combination of treatments
- Where
- 2 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Controlled Ovarian Stimulation, Infertility
Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART)
The study is a prospective, randomised, controlled, and non-blinded multi-center pilot study to evaluate endocrine efficacy of recombinant luteinizing hormone versus recombinant human chorionic gonadotropin administered during…
- Trial name
- NCT01339299
- Testing
- recombinant luteinizing hormone (r-LH), recombinant human chorionic gonadotropin (r-hCG)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Regionshospitalet Viborg, Skive
Infertility
Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1
This trial investigates the effects of FE 999049 compared to GONAL-F.
- Trial name
- ESTHER-1 (NCT01956110)
- Testing
- Follitropin Delta (FE 999049), Follitropin Alfa (GONAL-F)
- Where
- 13 sites in Belgium, Brazil and 9 more
- Volunteers
- 1,329 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa
Prospective open label, randomised, parallel group, comparative pilot.
- Trial name
- NCT00257556
- Testing
- Menotrophin, Follitropin alfa
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovarian Syndrome, Infertility
Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)
This multicenter, randomized, open-label exploratory study will be performed in approximately 200 polycystic ovary syndrome (PCOS) but otherwise healthy females undergoing in vitro fertilization (IVF).
- Trial name
- NCT00805935
- Testing
- Menotropin, Progesterone vaginal insert, Follitropin beta
- Where
- 6 sites in United States
- Volunteers
- 110 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Female
Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)
This a trial designed to test whether granulocyte colony stimulating factor (G-CSF, Neupogen) can increase the rate of embryo implantation following IVF and embryo transfer.
- Trial name
- NCT01202656
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Low Grade Glioma
Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide
The purpose of this study is to look at how a chemotherapy treatment (Temozolomide, also called Temodar) affects the process of ovarian aging which is measured by a decline in ovarian follicle count, in patients with Low Grade…
- Trial name
- OVA-LGG (NCT01452854)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco